Echocardiographic Findings and Genotypes in Autosomal Dominant Polycystic Kidney Disease
Background: Autosomal dominant polycystic kidney disease (ADPKD) is the most common hereditary cystic kidney disease and is well known to have extrarenal complications. Cardiovascular complications are of particular clinical relevance because of their morbidity and mortality; however, unclear is why...
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Karger Publishers
2021
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oai:doaj.org-article:20159581ebd24ead92911dd6a7f85b822021-12-02T12:40:23ZEchocardiographic Findings and Genotypes in Autosomal Dominant Polycystic Kidney Disease2296-93812296-935710.1159/000520300https://doaj.org/article/20159581ebd24ead92911dd6a7f85b822021-11-01T00:00:00Zhttps://www.karger.com/Article/FullText/520300https://doaj.org/toc/2296-9381https://doaj.org/toc/2296-9357Background: Autosomal dominant polycystic kidney disease (ADPKD) is the most common hereditary cystic kidney disease and is well known to have extrarenal complications. Cardiovascular complications are of particular clinical relevance because of their morbidity and mortality; however, unclear is why they occur so frequently in patients with ADPKD and whether they are related to the genotypes. Methods: We extracted and retrospectively analyzed clinical data on patients with ADPKD who underwent echocardiography and whose genotype was confirmed by genetic testing between April 2016 and December 2020. We used next-generation sequencing to compare cardiac function, structural data, and the presence of cardiac valvular disease in patients with 1 of 3 genotypes: PKD1, PKD2, and non-PKD1, 2. Results: This retrospective study included 65 patients with ADPKD. Patients were divided into 3 groups: PKD1, n = 32; PKD2, n = 12; and non-PKD1, 2, n = 21. The prevalence of mitral regurgitation (MR) was significantly higher in the PKD1 group than in the PKD2 and non-PKD1, 2 group (46.9% vs. 8.3% vs. 19.0%, respectively; p = 0.02). In contrast, no significant difference was found for other cardiac valve complications. Conclusion: This study found a significantly higher prevalence of MR in patients with the PKD1 genotype than in those with the PKD2 or non-PKD1, 2 genotypes. Physicians may need to perform echocardiography earlier and more frequently in patients with ADPKD and the PKD1 genotype and to control fluid volume and blood pressure more strictly in these patients to prevent future cardiac events.Ryohei MiyamotoAkinari SekineTakuya FujimaruTatsuya SuwabeHiroki MizunoEiko HasegawaMasayuki YamanouchiMotoko ChigaTakayasu MoriEisei SoharaShinichi UchidaNaoki SawaYoshifumi UbaraJunichi HoshinoKarger Publishersarticleautosomal dominant polycystic kidney diseasepkd1pkd2mitral regurgitationcardiovascular diseaseInternal medicineRC31-1245ENKidney Diseases, Pp 1-7 (2021) |
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DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
autosomal dominant polycystic kidney disease pkd1 pkd2 mitral regurgitation cardiovascular disease Internal medicine RC31-1245 |
| spellingShingle |
autosomal dominant polycystic kidney disease pkd1 pkd2 mitral regurgitation cardiovascular disease Internal medicine RC31-1245 Ryohei Miyamoto Akinari Sekine Takuya Fujimaru Tatsuya Suwabe Hiroki Mizuno Eiko Hasegawa Masayuki Yamanouchi Motoko Chiga Takayasu Mori Eisei Sohara Shinichi Uchida Naoki Sawa Yoshifumi Ubara Junichi Hoshino Echocardiographic Findings and Genotypes in Autosomal Dominant Polycystic Kidney Disease |
| description |
Background: Autosomal dominant polycystic kidney disease (ADPKD) is the most common hereditary cystic kidney disease and is well known to have extrarenal complications. Cardiovascular complications are of particular clinical relevance because of their morbidity and mortality; however, unclear is why they occur so frequently in patients with ADPKD and whether they are related to the genotypes. Methods: We extracted and retrospectively analyzed clinical data on patients with ADPKD who underwent echocardiography and whose genotype was confirmed by genetic testing between April 2016 and December 2020. We used next-generation sequencing to compare cardiac function, structural data, and the presence of cardiac valvular disease in patients with 1 of 3 genotypes: PKD1, PKD2, and non-PKD1, 2. Results: This retrospective study included 65 patients with ADPKD. Patients were divided into 3 groups: PKD1, n = 32; PKD2, n = 12; and non-PKD1, 2, n = 21. The prevalence of mitral regurgitation (MR) was significantly higher in the PKD1 group than in the PKD2 and non-PKD1, 2 group (46.9% vs. 8.3% vs. 19.0%, respectively; p = 0.02). In contrast, no significant difference was found for other cardiac valve complications. Conclusion: This study found a significantly higher prevalence of MR in patients with the PKD1 genotype than in those with the PKD2 or non-PKD1, 2 genotypes. Physicians may need to perform echocardiography earlier and more frequently in patients with ADPKD and the PKD1 genotype and to control fluid volume and blood pressure more strictly in these patients to prevent future cardiac events. |
| format |
article |
| author |
Ryohei Miyamoto Akinari Sekine Takuya Fujimaru Tatsuya Suwabe Hiroki Mizuno Eiko Hasegawa Masayuki Yamanouchi Motoko Chiga Takayasu Mori Eisei Sohara Shinichi Uchida Naoki Sawa Yoshifumi Ubara Junichi Hoshino |
| author_facet |
Ryohei Miyamoto Akinari Sekine Takuya Fujimaru Tatsuya Suwabe Hiroki Mizuno Eiko Hasegawa Masayuki Yamanouchi Motoko Chiga Takayasu Mori Eisei Sohara Shinichi Uchida Naoki Sawa Yoshifumi Ubara Junichi Hoshino |
| author_sort |
Ryohei Miyamoto |
| title |
Echocardiographic Findings and Genotypes in Autosomal Dominant Polycystic Kidney Disease |
| title_short |
Echocardiographic Findings and Genotypes in Autosomal Dominant Polycystic Kidney Disease |
| title_full |
Echocardiographic Findings and Genotypes in Autosomal Dominant Polycystic Kidney Disease |
| title_fullStr |
Echocardiographic Findings and Genotypes in Autosomal Dominant Polycystic Kidney Disease |
| title_full_unstemmed |
Echocardiographic Findings and Genotypes in Autosomal Dominant Polycystic Kidney Disease |
| title_sort |
echocardiographic findings and genotypes in autosomal dominant polycystic kidney disease |
| publisher |
Karger Publishers |
| publishDate |
2021 |
| url |
https://doaj.org/article/20159581ebd24ead92911dd6a7f85b82 |
| work_keys_str_mv |
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