Biomedical Applications of TiO2 Nanostructures: Recent Advances

Sevda Jafari,1,2 Baharak Mahyad,3 Hadi Hashemzadeh,4 Sajjad Janfaza,4 Tooba Gholikhani,2 Lobat Tayebi5 1Biotechnology Research Center, Tabriz University of Medical Sciences, Tabriz, Islamic Republic of Iran; 2Student Research Committee, Faculty of Pharmacy, Tabriz University of Medical Sciences, Tab...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Jafari S, Mahyad B, Hashemzadeh H, Janfaza S, Gholikhani T, Tayebi L
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	titanium dioxide nanomaterial drug release antibacterial implants biosensors nanotoxicity. Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/20160a6f9776476f930b517036761432
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:20160a6f9776476f930b517036761432
record_format	dspace
spelling	oai:doaj.org-article:20160a6f9776476f930b5170367614322021-12-02T08:20:51ZBiomedical Applications of TiO2 Nanostructures: Recent Advances1178-2013https://doaj.org/article/20160a6f9776476f930b5170367614322020-05-01T00:00:00Zhttps://www.dovepress.com/biomedical-applications-of-tio2-nanostructures-recent-advances-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Sevda Jafari,1,2 Baharak Mahyad,3 Hadi Hashemzadeh,4 Sajjad Janfaza,4 Tooba Gholikhani,2 Lobat Tayebi5 1Biotechnology Research Center, Tabriz University of Medical Sciences, Tabriz, Islamic Republic of Iran; 2Student Research Committee, Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Islamic Republic of Iran; 3Department of Life Science Engineering, Faculty of New Science and Technologies, University of Tehran, Tehran, Islamic Republic of Iran; 4Department of Nanobiotechnology, Tarbiat Modares University, Tehran, 14117, Islamic Republic of Iran; 5Marquette University School of Dentistry, Milwaukee, WI 53233, USACorrespondence: Hadi Hashemzadeh; Sajjad JanfazaDepartment of Nanobiotechnology, Tarbiat Modares University, Jalal Ale Ahmad Highway, Tehran 14117, Islamic Republic of IranTel +98 2182880000Email Hadi.hashemzadeh@modares.ac.ir; sajad.janfaza@gmail.comAbstract: Titanium dioxide (TiO2) nanostructures are one of the most plentiful compounds that have emerged in various fields of technology such as medicine, energy and biosensing. Various TiO2 nanostructures (nanotubes [NTs] and nanowires) have been employed in photoelectrochemical (PEC) biosensing applications, greatly enhancing the detection of targets. TiO2 nanostructures, used as reinforced material or coatings for the bare surface of titanium implants, are excellent additive materials to compensate titanium implants deficiencies—like poor surface interaction with surrounding tissues—by providing nanoporous surfaces and hierarchical structures. These nanostructures can also be loaded by diversified drugs—like osteoporosis drugs, anticancer and antibiotics—and used as local drug delivery systems. Furthermore, TiO2 nanostructures and their derivatives are new emerging antimicrobial agents to overcome human pathogenic microorganisms. However, like all other nanomaterials, toxicity and biocompatibility of TiO2 nanostructures must be considered. This review highlights recent advances, along with the properties and numerous applications of TiO2-based nanostructure compounds in nano biosensing, medical implants, drug delivery and antibacterial fields. Moreover, in the present study, some recent advances accomplished on the pharmaceutical applications of TiO2 nanostructures, as well as its toxicity and biocompatibility, are presented.Keywords: titanium dioxide nanomaterial, drug release, antibacterial, implants, biosensors, nanotoxicityJafari SMahyad BHashemzadeh HJanfaza SGholikhani TTayebi LDove Medical Pressarticletitanium dioxide nanomaterialdrug releaseantibacterialimplantsbiosensorsnanotoxicity.Medicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 15, Pp 3447-3470 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	titanium dioxide nanomaterial drug release antibacterial implants biosensors nanotoxicity. Medicine (General) R5-920
spellingShingle	titanium dioxide nanomaterial drug release antibacterial implants biosensors nanotoxicity. Medicine (General) R5-920 Jafari S Mahyad B Hashemzadeh H Janfaza S Gholikhani T Tayebi L Biomedical Applications of TiO2 Nanostructures: Recent Advances
description	Sevda Jafari,1,2 Baharak Mahyad,3 Hadi Hashemzadeh,4 Sajjad Janfaza,4 Tooba Gholikhani,2 Lobat Tayebi5 1Biotechnology Research Center, Tabriz University of Medical Sciences, Tabriz, Islamic Republic of Iran; 2Student Research Committee, Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Islamic Republic of Iran; 3Department of Life Science Engineering, Faculty of New Science and Technologies, University of Tehran, Tehran, Islamic Republic of Iran; 4Department of Nanobiotechnology, Tarbiat Modares University, Tehran, 14117, Islamic Republic of Iran; 5Marquette University School of Dentistry, Milwaukee, WI 53233, USACorrespondence: Hadi Hashemzadeh; Sajjad JanfazaDepartment of Nanobiotechnology, Tarbiat Modares University, Jalal Ale Ahmad Highway, Tehran 14117, Islamic Republic of IranTel +98 2182880000Email Hadi.hashemzadeh@modares.ac.ir; sajad.janfaza@gmail.comAbstract: Titanium dioxide (TiO2) nanostructures are one of the most plentiful compounds that have emerged in various fields of technology such as medicine, energy and biosensing. Various TiO2 nanostructures (nanotubes [NTs] and nanowires) have been employed in photoelectrochemical (PEC) biosensing applications, greatly enhancing the detection of targets. TiO2 nanostructures, used as reinforced material or coatings for the bare surface of titanium implants, are excellent additive materials to compensate titanium implants deficiencies—like poor surface interaction with surrounding tissues—by providing nanoporous surfaces and hierarchical structures. These nanostructures can also be loaded by diversified drugs—like osteoporosis drugs, anticancer and antibiotics—and used as local drug delivery systems. Furthermore, TiO2 nanostructures and their derivatives are new emerging antimicrobial agents to overcome human pathogenic microorganisms. However, like all other nanomaterials, toxicity and biocompatibility of TiO2 nanostructures must be considered. This review highlights recent advances, along with the properties and numerous applications of TiO2-based nanostructure compounds in nano biosensing, medical implants, drug delivery and antibacterial fields. Moreover, in the present study, some recent advances accomplished on the pharmaceutical applications of TiO2 nanostructures, as well as its toxicity and biocompatibility, are presented.Keywords: titanium dioxide nanomaterial, drug release, antibacterial, implants, biosensors, nanotoxicity
format	article
author	Jafari S Mahyad B Hashemzadeh H Janfaza S Gholikhani T Tayebi L
author_facet	Jafari S Mahyad B Hashemzadeh H Janfaza S Gholikhani T Tayebi L
author_sort	Jafari S
title	Biomedical Applications of TiO2 Nanostructures: Recent Advances
title_short	Biomedical Applications of TiO2 Nanostructures: Recent Advances
title_full	Biomedical Applications of TiO2 Nanostructures: Recent Advances
title_fullStr	Biomedical Applications of TiO2 Nanostructures: Recent Advances
title_full_unstemmed	Biomedical Applications of TiO2 Nanostructures: Recent Advances
title_sort	biomedical applications of tio2 nanostructures: recent advances
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/20160a6f9776476f930b517036761432
work_keys_str_mv	AT jafaris biomedicalapplicationsoftio2nanostructuresrecentadvances AT mahyadb biomedicalapplicationsoftio2nanostructuresrecentadvances AT hashemzadehh biomedicalapplicationsoftio2nanostructuresrecentadvances AT janfazas biomedicalapplicationsoftio2nanostructuresrecentadvances AT gholikhanit biomedicalapplicationsoftio2nanostructuresrecentadvances AT tayebil biomedicalapplicationsoftio2nanostructuresrecentadvances
_version_	1718398532349591552

Biomedical Applications of TiO2 Nanostructures: Recent Advances

Ejemplares similares