Pax3 cooperates with Ldb1 to direct local chromosome architecture during myogenic lineage specification

Chromatin looping allows for enhancer–promoter interactions that regulate transcription. Here the authors show that activation of embryonic myogenesis is associated with establishment of long-range chromatin interactions centred on Pax3-bound loci and find that Ldb1 functions as the mediator of loop...

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Autores principales:	Alessandro Magli, June Baik, Pruthvi Pota, Carolina Ortiz Cordero, Il-Youp Kwak, Daniel J. Garry, Paul E. Love, Brian D. Dynlacht, Rita C. R. Perlingeiro
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/2017286161c64664ab578062da59d741
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id	oai:doaj.org-article:2017286161c64664ab578062da59d741
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spelling	oai:doaj.org-article:2017286161c64664ab578062da59d7412021-12-02T14:38:45ZPax3 cooperates with Ldb1 to direct local chromosome architecture during myogenic lineage specification10.1038/s41467-019-10318-62041-1723https://doaj.org/article/2017286161c64664ab578062da59d7412019-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10318-6https://doaj.org/toc/2041-1723Chromatin looping allows for enhancer–promoter interactions that regulate transcription. Here the authors show that activation of embryonic myogenesis is associated with establishment of long-range chromatin interactions centred on Pax3-bound loci and find that Ldb1 functions as the mediator of looping interactions at a subset of Pax3 binding sites.Alessandro MagliJune BaikPruthvi PotaCarolina Ortiz CorderoIl-Youp KwakDaniel J. GarryPaul E. LoveBrian D. DynlachtRita C. R. PerlingeiroNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Alessandro Magli June Baik Pruthvi Pota Carolina Ortiz Cordero Il-Youp Kwak Daniel J. Garry Paul E. Love Brian D. Dynlacht Rita C. R. Perlingeiro Pax3 cooperates with Ldb1 to direct local chromosome architecture during myogenic lineage specification
description	Chromatin looping allows for enhancer–promoter interactions that regulate transcription. Here the authors show that activation of embryonic myogenesis is associated with establishment of long-range chromatin interactions centred on Pax3-bound loci and find that Ldb1 functions as the mediator of looping interactions at a subset of Pax3 binding sites.
format	article
author	Alessandro Magli June Baik Pruthvi Pota Carolina Ortiz Cordero Il-Youp Kwak Daniel J. Garry Paul E. Love Brian D. Dynlacht Rita C. R. Perlingeiro
author_facet	Alessandro Magli June Baik Pruthvi Pota Carolina Ortiz Cordero Il-Youp Kwak Daniel J. Garry Paul E. Love Brian D. Dynlacht Rita C. R. Perlingeiro
author_sort	Alessandro Magli
title	Pax3 cooperates with Ldb1 to direct local chromosome architecture during myogenic lineage specification
title_short	Pax3 cooperates with Ldb1 to direct local chromosome architecture during myogenic lineage specification
title_full	Pax3 cooperates with Ldb1 to direct local chromosome architecture during myogenic lineage specification
title_fullStr	Pax3 cooperates with Ldb1 to direct local chromosome architecture during myogenic lineage specification
title_full_unstemmed	Pax3 cooperates with Ldb1 to direct local chromosome architecture during myogenic lineage specification
title_sort	pax3 cooperates with ldb1 to direct local chromosome architecture during myogenic lineage specification
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/2017286161c64664ab578062da59d741
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Pax3 cooperates with Ldb1 to direct local chromosome architecture during myogenic lineage specification

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