Structural insights of human mitofusin-2 into mitochondrial fusion and CMT2A onset
Mitofusin-2 (MFN2) is a dynamin-like GTPase that plays a central role in regulating mitochondrial fusion and cell metabolism. Here, authors report crystal structures of truncated human MFN2 in different nucleotide-loading states and show that MFN2 forms sustained dimers even after GTP hydrolysis.
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Nature Portfolio
2019
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oai:doaj.org-article:20184dcb3f0a4e0db34a9f78850e0d8f2021-12-02T16:57:11ZStructural insights of human mitofusin-2 into mitochondrial fusion and CMT2A onset10.1038/s41467-019-12912-02041-1723https://doaj.org/article/20184dcb3f0a4e0db34a9f78850e0d8f2019-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12912-0https://doaj.org/toc/2041-1723Mitofusin-2 (MFN2) is a dynamin-like GTPase that plays a central role in regulating mitochondrial fusion and cell metabolism. Here, authors report crystal structures of truncated human MFN2 in different nucleotide-loading states and show that MFN2 forms sustained dimers even after GTP hydrolysis.Yu-Jie LiYu-Lu CaoJian-Xiong FengYuanbo QiShuxia MengJie-Feng YangYa-Ting ZhongSisi KangXiaoxue ChenLan LanLi LuoBing YuShoudeng ChenDavid C. ChanJunjie HuSong GaoNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019) |
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Science Q |
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Science Q Yu-Jie Li Yu-Lu Cao Jian-Xiong Feng Yuanbo Qi Shuxia Meng Jie-Feng Yang Ya-Ting Zhong Sisi Kang Xiaoxue Chen Lan Lan Li Luo Bing Yu Shoudeng Chen David C. Chan Junjie Hu Song Gao Structural insights of human mitofusin-2 into mitochondrial fusion and CMT2A onset |
description |
Mitofusin-2 (MFN2) is a dynamin-like GTPase that plays a central role in regulating mitochondrial fusion and cell metabolism. Here, authors report crystal structures of truncated human MFN2 in different nucleotide-loading states and show that MFN2 forms sustained dimers even after GTP hydrolysis. |
format |
article |
author |
Yu-Jie Li Yu-Lu Cao Jian-Xiong Feng Yuanbo Qi Shuxia Meng Jie-Feng Yang Ya-Ting Zhong Sisi Kang Xiaoxue Chen Lan Lan Li Luo Bing Yu Shoudeng Chen David C. Chan Junjie Hu Song Gao |
author_facet |
Yu-Jie Li Yu-Lu Cao Jian-Xiong Feng Yuanbo Qi Shuxia Meng Jie-Feng Yang Ya-Ting Zhong Sisi Kang Xiaoxue Chen Lan Lan Li Luo Bing Yu Shoudeng Chen David C. Chan Junjie Hu Song Gao |
author_sort |
Yu-Jie Li |
title |
Structural insights of human mitofusin-2 into mitochondrial fusion and CMT2A onset |
title_short |
Structural insights of human mitofusin-2 into mitochondrial fusion and CMT2A onset |
title_full |
Structural insights of human mitofusin-2 into mitochondrial fusion and CMT2A onset |
title_fullStr |
Structural insights of human mitofusin-2 into mitochondrial fusion and CMT2A onset |
title_full_unstemmed |
Structural insights of human mitofusin-2 into mitochondrial fusion and CMT2A onset |
title_sort |
structural insights of human mitofusin-2 into mitochondrial fusion and cmt2a onset |
publisher |
Nature Portfolio |
publishDate |
2019 |
url |
https://doaj.org/article/20184dcb3f0a4e0db34a9f78850e0d8f |
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