Cosmc controls B cell homing

Migration and homing of B cells to lymph nodes are important for B cell functions, but their regulation is poorly understood. Here, the authors show that B cell-specific deletion of Cosmc results in decreased protein O-glycosylation, loss of B cell homing to both lymphoid and nonlymphoid organs, and...

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Autores principales:	Junwei Zeng, Mahmoud Eljalby, Rajindra P. Aryal, Sylvain Lehoux, Kathrin Stavenhagen, Matthew R. Kudelka, Yingchun Wang, Jianmei Wang, Tongzhong Ju, Ulrich H. von Andrian, Richard D. Cummings
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/201a4415154f465d96442116a4e136c2
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spelling	oai:doaj.org-article:201a4415154f465d96442116a4e136c22021-12-02T19:06:44ZCosmc controls B cell homing10.1038/s41467-020-17765-62041-1723https://doaj.org/article/201a4415154f465d96442116a4e136c22020-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17765-6https://doaj.org/toc/2041-1723Migration and homing of B cells to lymph nodes are important for B cell functions, but their regulation is poorly understood. Here, the authors show that B cell-specific deletion of Cosmc results in decreased protein O-glycosylation, loss of B cell homing to both lymphoid and nonlymphoid organs, and altered transendothelial migration implicated in this loss.Junwei ZengMahmoud EljalbyRajindra P. AryalSylvain LehouxKathrin StavenhagenMatthew R. KudelkaYingchun WangJianmei WangTongzhong JuUlrich H. von AndrianRichard D. CummingsNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Junwei Zeng Mahmoud Eljalby Rajindra P. Aryal Sylvain Lehoux Kathrin Stavenhagen Matthew R. Kudelka Yingchun Wang Jianmei Wang Tongzhong Ju Ulrich H. von Andrian Richard D. Cummings Cosmc controls B cell homing
description	Migration and homing of B cells to lymph nodes are important for B cell functions, but their regulation is poorly understood. Here, the authors show that B cell-specific deletion of Cosmc results in decreased protein O-glycosylation, loss of B cell homing to both lymphoid and nonlymphoid organs, and altered transendothelial migration implicated in this loss.
format	article
author	Junwei Zeng Mahmoud Eljalby Rajindra P. Aryal Sylvain Lehoux Kathrin Stavenhagen Matthew R. Kudelka Yingchun Wang Jianmei Wang Tongzhong Ju Ulrich H. von Andrian Richard D. Cummings
author_facet	Junwei Zeng Mahmoud Eljalby Rajindra P. Aryal Sylvain Lehoux Kathrin Stavenhagen Matthew R. Kudelka Yingchun Wang Jianmei Wang Tongzhong Ju Ulrich H. von Andrian Richard D. Cummings
author_sort	Junwei Zeng
title	Cosmc controls B cell homing
title_short	Cosmc controls B cell homing
title_full	Cosmc controls B cell homing
title_fullStr	Cosmc controls B cell homing
title_full_unstemmed	Cosmc controls B cell homing
title_sort	cosmc controls b cell homing
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/201a4415154f465d96442116a4e136c2
work_keys_str_mv	AT junweizeng cosmccontrolsbcellhoming AT mahmoudeljalby cosmccontrolsbcellhoming AT rajindraparyal cosmccontrolsbcellhoming AT sylvainlehoux cosmccontrolsbcellhoming AT kathrinstavenhagen cosmccontrolsbcellhoming AT matthewrkudelka cosmccontrolsbcellhoming AT yingchunwang cosmccontrolsbcellhoming AT jianmeiwang cosmccontrolsbcellhoming AT tongzhongju cosmccontrolsbcellhoming AT ulrichhvonandrian cosmccontrolsbcellhoming AT richarddcummings cosmccontrolsbcellhoming
_version_	1718377134757511168

Cosmc controls B cell homing

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