Dissecting Motor and Cognitive Component Processes of a Finger-Tapping Task With Hybrid Dopamine Positron Emission Tomography and Functional Magnetic Resonance Imaging
Striatal dopamine is involved in facilitation of motor action as well as various cognitive and emotional functions. Positron emission tomography (PET) is the primary imaging method used to investigate dopamine function in humans. Previous PET studies have shown striatal dopamine release during simpl...
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Frontiers Media S.A.
2021
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oai:doaj.org-article:201e33876f1741ac9cdb3995e0398f4d2021-12-01T13:43:05ZDissecting Motor and Cognitive Component Processes of a Finger-Tapping Task With Hybrid Dopamine Positron Emission Tomography and Functional Magnetic Resonance Imaging1662-516110.3389/fnhum.2021.733091https://doaj.org/article/201e33876f1741ac9cdb3995e0398f4d2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fnhum.2021.733091/fullhttps://doaj.org/toc/1662-5161Striatal dopamine is involved in facilitation of motor action as well as various cognitive and emotional functions. Positron emission tomography (PET) is the primary imaging method used to investigate dopamine function in humans. Previous PET studies have shown striatal dopamine release during simple finger tapping in both the putamen and the caudate. It is likely that dopamine release in the putamen is related to motor processes while dopamine release in the caudate could signal sustained cognitive component processes of the task, but the poor temporal resolution of PET has hindered firm conclusions. In this study we simultaneously collected [11C]Raclopride PET and functional Magnetic Resonance Imaging (fMRI) data while participants performed finger tapping, with fMRI being able to isolate activations related to individual tapping events. The results revealed fMRI-PET overlap in the bilateral putamen, which is consistent with a motor component process. Selective PET responses in the caudate, ventral striatum, and right posterior putamen, were also observed but did not overlap with fMRI responses to tapping events, suggesting that these reflect non-motor component processes of finger tapping. Our findings suggest an interplay between motor and non-motor-related dopamine release during simple finger tapping and illustrate the potential of hybrid PET-fMRI in revealing distinct component processes of cognitive functions.Filip GrillFilip GrillJarkko JohanssonJarkko JohanssonJan AxelssonJan AxelssonPatrik BrynolfssonPatrik BrynolfssonLars NybergLars NybergLars NybergAnna RieckmannAnna RieckmannAnna RieckmannAnna RieckmannFrontiers Media S.A.articlefinger tappingPETfMRIdopaminecognitive componentstriatumNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENFrontiers in Human Neuroscience, Vol 15 (2021) |
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finger tapping PET fMRI dopamine cognitive component striatum Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 |
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finger tapping PET fMRI dopamine cognitive component striatum Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Filip Grill Filip Grill Jarkko Johansson Jarkko Johansson Jan Axelsson Jan Axelsson Patrik Brynolfsson Patrik Brynolfsson Lars Nyberg Lars Nyberg Lars Nyberg Anna Rieckmann Anna Rieckmann Anna Rieckmann Anna Rieckmann Dissecting Motor and Cognitive Component Processes of a Finger-Tapping Task With Hybrid Dopamine Positron Emission Tomography and Functional Magnetic Resonance Imaging |
| description |
Striatal dopamine is involved in facilitation of motor action as well as various cognitive and emotional functions. Positron emission tomography (PET) is the primary imaging method used to investigate dopamine function in humans. Previous PET studies have shown striatal dopamine release during simple finger tapping in both the putamen and the caudate. It is likely that dopamine release in the putamen is related to motor processes while dopamine release in the caudate could signal sustained cognitive component processes of the task, but the poor temporal resolution of PET has hindered firm conclusions. In this study we simultaneously collected [11C]Raclopride PET and functional Magnetic Resonance Imaging (fMRI) data while participants performed finger tapping, with fMRI being able to isolate activations related to individual tapping events. The results revealed fMRI-PET overlap in the bilateral putamen, which is consistent with a motor component process. Selective PET responses in the caudate, ventral striatum, and right posterior putamen, were also observed but did not overlap with fMRI responses to tapping events, suggesting that these reflect non-motor component processes of finger tapping. Our findings suggest an interplay between motor and non-motor-related dopamine release during simple finger tapping and illustrate the potential of hybrid PET-fMRI in revealing distinct component processes of cognitive functions. |
| format |
article |
| author |
Filip Grill Filip Grill Jarkko Johansson Jarkko Johansson Jan Axelsson Jan Axelsson Patrik Brynolfsson Patrik Brynolfsson Lars Nyberg Lars Nyberg Lars Nyberg Anna Rieckmann Anna Rieckmann Anna Rieckmann Anna Rieckmann |
| author_facet |
Filip Grill Filip Grill Jarkko Johansson Jarkko Johansson Jan Axelsson Jan Axelsson Patrik Brynolfsson Patrik Brynolfsson Lars Nyberg Lars Nyberg Lars Nyberg Anna Rieckmann Anna Rieckmann Anna Rieckmann Anna Rieckmann |
| author_sort |
Filip Grill |
| title |
Dissecting Motor and Cognitive Component Processes of a Finger-Tapping Task With Hybrid Dopamine Positron Emission Tomography and Functional Magnetic Resonance Imaging |
| title_short |
Dissecting Motor and Cognitive Component Processes of a Finger-Tapping Task With Hybrid Dopamine Positron Emission Tomography and Functional Magnetic Resonance Imaging |
| title_full |
Dissecting Motor and Cognitive Component Processes of a Finger-Tapping Task With Hybrid Dopamine Positron Emission Tomography and Functional Magnetic Resonance Imaging |
| title_fullStr |
Dissecting Motor and Cognitive Component Processes of a Finger-Tapping Task With Hybrid Dopamine Positron Emission Tomography and Functional Magnetic Resonance Imaging |
| title_full_unstemmed |
Dissecting Motor and Cognitive Component Processes of a Finger-Tapping Task With Hybrid Dopamine Positron Emission Tomography and Functional Magnetic Resonance Imaging |
| title_sort |
dissecting motor and cognitive component processes of a finger-tapping task with hybrid dopamine positron emission tomography and functional magnetic resonance imaging |
| publisher |
Frontiers Media S.A. |
| publishDate |
2021 |
| url |
https://doaj.org/article/201e33876f1741ac9cdb3995e0398f4d |
| work_keys_str_mv |
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