THE EFFECT OF HYPOXIC BRAIN DAMAGE ON THE SURVIVAL OF PREMATURE INFANTS

The central nervous system injuries are a common neonatal pathology, hypoxia being one of the main causes of cerebral dysfunction. The purpose of this study was studying the incidence of hypoxic cerebral disorders in premature infants with an extremely low body weight and a very low birth weight and...

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Autores principales:	N. V. Likholetova, A. M. Anuryev, S. M. Gorbacheva, T. I. Pavlova, A. B. Pavlov
Formato:	article
Lenguaje:	RU
Publicado:	Scientific Сentre for Family Health and Human Reproduction Problems 2018
Materias:	cerebral disorders intraventricular hemorrhage hypoxia preterm infants Science Q
Acceso en línea:	https://doaj.org/article/201f9381e5c843118a0d5c39c6563860
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spelling	oai:doaj.org-article:201f9381e5c843118a0d5c39c65638602021-11-23T06:14:41ZTHE EFFECT OF HYPOXIC BRAIN DAMAGE ON THE SURVIVAL OF PREMATURE INFANTS2541-94202587-959610.29413/ABS.2018-3.5.12https://doaj.org/article/201f9381e5c843118a0d5c39c65638602018-09-01T00:00:00Zhttps://www.actabiomedica.ru/jour/article/view/711https://doaj.org/toc/2541-9420https://doaj.org/toc/2587-9596The central nervous system injuries are a common neonatal pathology, hypoxia being one of the main causes of cerebral dysfunction. The purpose of this study was studying the incidence of hypoxic cerebral disorders in premature infants with an extremely low body weight and a very low birth weight and revealing the risk factors that adversely affected the disease outcome. The subject of the study was preterm infants whose gestational age did not exceed 31 weeks. The main criterion for inclusion into the study was the presence of hypoxic-ischemic and hypoxic-hemorrhagic brain damage. To reveal the perinatal risk factors, the somatic health of mothers, and pregnancy and childbirth peculiarities were studied. The structure of children’s pathology and intensive care techniques were analyzed. Cerebral disorders were verified in 42 out of 176 patients (23.5 %). 2–3rd-degree intraventricular hemorrhage was diagnosed in 34 newborns (80.9 %), severe ischemia in 8 children (19.1 %). To determine the structure of the disease outcome, all children were divided into deceased and survivors. A fatal outcome was observed in 14 cases (33.3 %). The mothers of deceased children were more likely to have obstetric and concomitant extragenital pathologies. Analysis of pediatric pathology showed that the hemodynamically significant functioning arterial duct and severe asphyxia in childbirth were much more frequent in deceased children. Intensive therapy of deceased children included «hard» parameters of artificial ventilation and high doses of cardiotonic drugs. Thus the presented risk factors can be considered as predictors of an unfavorable outcome in children with this pathology.N. V. LikholetovaA. M. AnuryevS. M. GorbachevaT. I. PavlovaA. B. PavlovScientific Сentre for Family Health and Human Reproduction Problemsarticlecerebral disordersintraventricular hemorrhagehypoxiapreterm infantsScienceQRUActa Biomedica Scientifica, Vol 3, Iss 5, Pp 76-81 (2018)
institution	DOAJ
collection	DOAJ
language	RU
topic	cerebral disorders intraventricular hemorrhage hypoxia preterm infants Science Q
spellingShingle	cerebral disorders intraventricular hemorrhage hypoxia preterm infants Science Q N. V. Likholetova A. M. Anuryev S. M. Gorbacheva T. I. Pavlova A. B. Pavlov THE EFFECT OF HYPOXIC BRAIN DAMAGE ON THE SURVIVAL OF PREMATURE INFANTS
description	The central nervous system injuries are a common neonatal pathology, hypoxia being one of the main causes of cerebral dysfunction. The purpose of this study was studying the incidence of hypoxic cerebral disorders in premature infants with an extremely low body weight and a very low birth weight and revealing the risk factors that adversely affected the disease outcome. The subject of the study was preterm infants whose gestational age did not exceed 31 weeks. The main criterion for inclusion into the study was the presence of hypoxic-ischemic and hypoxic-hemorrhagic brain damage. To reveal the perinatal risk factors, the somatic health of mothers, and pregnancy and childbirth peculiarities were studied. The structure of children’s pathology and intensive care techniques were analyzed. Cerebral disorders were verified in 42 out of 176 patients (23.5 %). 2–3rd-degree intraventricular hemorrhage was diagnosed in 34 newborns (80.9 %), severe ischemia in 8 children (19.1 %). To determine the structure of the disease outcome, all children were divided into deceased and survivors. A fatal outcome was observed in 14 cases (33.3 %). The mothers of deceased children were more likely to have obstetric and concomitant extragenital pathologies. Analysis of pediatric pathology showed that the hemodynamically significant functioning arterial duct and severe asphyxia in childbirth were much more frequent in deceased children. Intensive therapy of deceased children included «hard» parameters of artificial ventilation and high doses of cardiotonic drugs. Thus the presented risk factors can be considered as predictors of an unfavorable outcome in children with this pathology.
format	article
author	N. V. Likholetova A. M. Anuryev S. M. Gorbacheva T. I. Pavlova A. B. Pavlov
author_facet	N. V. Likholetova A. M. Anuryev S. M. Gorbacheva T. I. Pavlova A. B. Pavlov
author_sort	N. V. Likholetova
title	THE EFFECT OF HYPOXIC BRAIN DAMAGE ON THE SURVIVAL OF PREMATURE INFANTS
title_short	THE EFFECT OF HYPOXIC BRAIN DAMAGE ON THE SURVIVAL OF PREMATURE INFANTS
title_full	THE EFFECT OF HYPOXIC BRAIN DAMAGE ON THE SURVIVAL OF PREMATURE INFANTS
title_fullStr	THE EFFECT OF HYPOXIC BRAIN DAMAGE ON THE SURVIVAL OF PREMATURE INFANTS
title_full_unstemmed	THE EFFECT OF HYPOXIC BRAIN DAMAGE ON THE SURVIVAL OF PREMATURE INFANTS
title_sort	effect of hypoxic brain damage on the survival of premature infants
publisher	Scientific Сentre for Family Health and Human Reproduction Problems
publishDate	2018
url	https://doaj.org/article/201f9381e5c843118a0d5c39c6563860
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THE EFFECT OF HYPOXIC BRAIN DAMAGE ON THE SURVIVAL OF PREMATURE INFANTS

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