Effect of a Remotely Delivered Weight Loss Intervention in Early-Stage Breast Cancer: Randomized Controlled Trial

Limited evidence exists on the effects of weight loss on chronic disease risk and patient-reported outcomes in breast cancer survivors. Breast cancer survivors (stage I–III; body mass index 25–45 kg/m<sup>2</sup>) were randomized to a 12-month, remotely delivered (22 telephone calls, mai...

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Autores principales:	Marina M. Reeves, Caroline O. Terranova, Elisabeth A. H. Winkler, Nicole McCarthy, Ingrid J. Hickman, Robert S. Ware, Sheleigh P. Lawler, Elizabeth G. Eakin, Wendy Demark-Wahnefried
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	obesity exercise nutrition supportive care survivorship telehealth Nutrition. Foods and food supply TX341-641
Acceso en línea:	https://doaj.org/article/2023d5e75de347d2836babf2431922f2
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spelling	oai:doaj.org-article:2023d5e75de347d2836babf2431922f22021-11-25T18:36:41ZEffect of a Remotely Delivered Weight Loss Intervention in Early-Stage Breast Cancer: Randomized Controlled Trial10.3390/nu131140912072-6643https://doaj.org/article/2023d5e75de347d2836babf2431922f22021-11-01T00:00:00Zhttps://www.mdpi.com/2072-6643/13/11/4091https://doaj.org/toc/2072-6643Limited evidence exists on the effects of weight loss on chronic disease risk and patient-reported outcomes in breast cancer survivors. Breast cancer survivors (stage I–III; body mass index 25–45 kg/m<sup>2</sup>) were randomized to a 12-month, remotely delivered (22 telephone calls, mailed material, optional text messages) weight loss (diet and physical activity) intervention (<i>n</i> = 79) or usual care (<i>n</i> = 80). Weight loss (primary outcome), body composition, metabolic syndrome risk score and components, quality of life, fatigue, musculoskeletal pain, menopausal symptoms, fear of recurrence, and body image were assessed at baseline, 6 months, 12 months (primary endpoint), and 18 months. Participants were 55 ± 9 years and 10.7 ± 5.0 months post-diagnosis; retention was 81.8% (12 months) and 80.5% (18 months). At 12-months, intervention participants had significantly greater improvements in weight (−4.5% [95%CI: −6.5, −2.5]; <i>p</i> < 0.001), fat mass (−3.3 kg [−4.8, −1.9]; <i>p</i> < 0.001), metabolic syndrome risk score (−0.19 [−0.32, −0.05]; <i>p</i> = 0.006), waist circumference (−3.2 cm [−5.5, −0.9]; <i>p</i> = 0.007), fasting plasma glucose (−0.23 mmol/L [−0.44, −0.02]; <i>p</i> = 0.032), physical quality of life (2.7 [0.7, 4.6]; <i>p</i> = 0.007; Cohen’s effect size (<i>d</i>) = 0.40), musculoskeletal pain (−0.5 [−0.8, −0.2]; <i>p</i> = 0.003; <i>d</i> = 0.49), and body image (−0.2 [−0.4, −0.0]; <i>p</i> = 0.030; <i>d</i> = 0.31) than usual care. At 18 months, effects on weight, adiposity, and metabolic syndrome risk scores were sustained; however, significant reductions in lean mass were observed (−1.1 kg [−1.7, −0.4]; <i>p</i> < 0.001). This intervention led to sustained improvements in adiposity and metabolic syndrome risk.Marina M. ReevesCaroline O. TerranovaElisabeth A. H. WinklerNicole McCarthyIngrid J. HickmanRobert S. WareSheleigh P. LawlerElizabeth G. EakinWendy Demark-WahnefriedMDPI AGarticleobesityexercisenutritionsupportive caresurvivorshiptelehealthNutrition. Foods and food supplyTX341-641ENNutrients, Vol 13, Iss 4091, p 4091 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	obesity exercise nutrition supportive care survivorship telehealth Nutrition. Foods and food supply TX341-641
spellingShingle	obesity exercise nutrition supportive care survivorship telehealth Nutrition. Foods and food supply TX341-641 Marina M. Reeves Caroline O. Terranova Elisabeth A. H. Winkler Nicole McCarthy Ingrid J. Hickman Robert S. Ware Sheleigh P. Lawler Elizabeth G. Eakin Wendy Demark-Wahnefried Effect of a Remotely Delivered Weight Loss Intervention in Early-Stage Breast Cancer: Randomized Controlled Trial
description	Limited evidence exists on the effects of weight loss on chronic disease risk and patient-reported outcomes in breast cancer survivors. Breast cancer survivors (stage I–III; body mass index 25–45 kg/m<sup>2</sup>) were randomized to a 12-month, remotely delivered (22 telephone calls, mailed material, optional text messages) weight loss (diet and physical activity) intervention (<i>n</i> = 79) or usual care (<i>n</i> = 80). Weight loss (primary outcome), body composition, metabolic syndrome risk score and components, quality of life, fatigue, musculoskeletal pain, menopausal symptoms, fear of recurrence, and body image were assessed at baseline, 6 months, 12 months (primary endpoint), and 18 months. Participants were 55 ± 9 years and 10.7 ± 5.0 months post-diagnosis; retention was 81.8% (12 months) and 80.5% (18 months). At 12-months, intervention participants had significantly greater improvements in weight (−4.5% [95%CI: −6.5, −2.5]; <i>p</i> < 0.001), fat mass (−3.3 kg [−4.8, −1.9]; <i>p</i> < 0.001), metabolic syndrome risk score (−0.19 [−0.32, −0.05]; <i>p</i> = 0.006), waist circumference (−3.2 cm [−5.5, −0.9]; <i>p</i> = 0.007), fasting plasma glucose (−0.23 mmol/L [−0.44, −0.02]; <i>p</i> = 0.032), physical quality of life (2.7 [0.7, 4.6]; <i>p</i> = 0.007; Cohen’s effect size (<i>d</i>) = 0.40), musculoskeletal pain (−0.5 [−0.8, −0.2]; <i>p</i> = 0.003; <i>d</i> = 0.49), and body image (−0.2 [−0.4, −0.0]; <i>p</i> = 0.030; <i>d</i> = 0.31) than usual care. At 18 months, effects on weight, adiposity, and metabolic syndrome risk scores were sustained; however, significant reductions in lean mass were observed (−1.1 kg [−1.7, −0.4]; <i>p</i> < 0.001). This intervention led to sustained improvements in adiposity and metabolic syndrome risk.
format	article
author	Marina M. Reeves Caroline O. Terranova Elisabeth A. H. Winkler Nicole McCarthy Ingrid J. Hickman Robert S. Ware Sheleigh P. Lawler Elizabeth G. Eakin Wendy Demark-Wahnefried
author_facet	Marina M. Reeves Caroline O. Terranova Elisabeth A. H. Winkler Nicole McCarthy Ingrid J. Hickman Robert S. Ware Sheleigh P. Lawler Elizabeth G. Eakin Wendy Demark-Wahnefried
author_sort	Marina M. Reeves
title	Effect of a Remotely Delivered Weight Loss Intervention in Early-Stage Breast Cancer: Randomized Controlled Trial
title_short	Effect of a Remotely Delivered Weight Loss Intervention in Early-Stage Breast Cancer: Randomized Controlled Trial
title_full	Effect of a Remotely Delivered Weight Loss Intervention in Early-Stage Breast Cancer: Randomized Controlled Trial
title_fullStr	Effect of a Remotely Delivered Weight Loss Intervention in Early-Stage Breast Cancer: Randomized Controlled Trial
title_full_unstemmed	Effect of a Remotely Delivered Weight Loss Intervention in Early-Stage Breast Cancer: Randomized Controlled Trial
title_sort	effect of a remotely delivered weight loss intervention in early-stage breast cancer: randomized controlled trial
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/2023d5e75de347d2836babf2431922f2
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Effect of a Remotely Delivered Weight Loss Intervention in Early-Stage Breast Cancer: Randomized Controlled Trial

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