Self Nano-Emulsifying Drug Delivery System (SNEDDS) of Curcuma Mangga Val. Essential Oil and The Stability Study

Essential oil of Curcuma mangga Val. has been reported to have cytotoxic effect against cancer cell lines. But this oil is unstable in dispensing so that a self nano-emulsifying drug delivery system (SNEDDS) of the oil was conducted to solve the problem and improve its potency. In the study, optimiz...

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Autores principales:	Retno Sunarminingsih Sudibyo, Lukman Mahdi, Ronny Martien
Formato:	article
Lenguaje:	EN
Publicado:	Universitas Gadjah Mada 2020
Materias:	curcuma mangga val., essential oil, self nano-emulsifying drug delivery system (snedds), simplex lattice design (sld), particle size analyzer (psa). Pharmacy and materia medica RS1-441
Acceso en línea:	https://doaj.org/article/2024311459b64cb3ac7c644d44eb78ba
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spelling	oai:doaj.org-article:2024311459b64cb3ac7c644d44eb78ba2021-11-15T06:08:47ZSelf Nano-Emulsifying Drug Delivery System (SNEDDS) of Curcuma Mangga Val. Essential Oil and The Stability Study2338-94272338-948610.22146/ijp.584https://doaj.org/article/2024311459b64cb3ac7c644d44eb78ba2020-10-01T00:00:00Zhttps://jurnal.ugm.ac.id/v3/IJP/article/view/584https://doaj.org/toc/2338-9427https://doaj.org/toc/2338-9486Essential oil of Curcuma mangga Val. has been reported to have cytotoxic effect against cancer cell lines. But this oil is unstable in dispensing so that a self nano-emulsifying drug delivery system (SNEDDS) of the oil was conducted to solve the problem and improve its potency. In the study, optimization, verification, characterization, and stability test of the SNEDDS formula were carried out respectively by simplex lattice design (SLD) on Design Expert ver. 10 software, droplet size and Zeta potential determinations using particle size analyzer (PSA) instrument, as well as heating-cooling and freeze-thaw methods. The best SNEDDS formula resulted was Miglyol : Tween 80 : PEG 400 = 16.034% : 68.380% : 15.586%; with transmittance of 84.47 + 1.05%, droplet size of 15.75 nm, zeta potential of -8.54 mV, polydispersity index (PDI) of 0.188, emulsifying time of 49.67 + 1.7 seconds in distilled water, 24.33 + 4.19 seconds in artificial gastric fluid and 21.33 + 2.87 seconds in artificial intestine fluid. After a freeze-thaw test there was no change on the emulsion’s clarity, color, smell, as well as no separation, which means that the formula was stable thermodynamically. The optimum SNEDDS formula resulted has small particle size, better emulsifying time in artificial gastric and intestine fluids, as well as better thermodynamic stability, which in turn will improve the cytotoxic activity of the Curcuma mangga Val. rhizome oil toward cancer cells.Retno Sunarminingsih SudibyoLukman MahdiRonny MartienUniversitas Gadjah Madaarticlecurcuma mangga val., essential oil, self nano-emulsifying drug delivery system (snedds), simplex lattice design (sld), particle size analyzer (psa).Pharmacy and materia medicaRS1-441ENIndonesian Journal of Pharmacy, Pp 238-243 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	curcuma mangga val., essential oil, self nano-emulsifying drug delivery system (snedds), simplex lattice design (sld), particle size analyzer (psa). Pharmacy and materia medica RS1-441
spellingShingle	curcuma mangga val., essential oil, self nano-emulsifying drug delivery system (snedds), simplex lattice design (sld), particle size analyzer (psa). Pharmacy and materia medica RS1-441 Retno Sunarminingsih Sudibyo Lukman Mahdi Ronny Martien Self Nano-Emulsifying Drug Delivery System (SNEDDS) of Curcuma Mangga Val. Essential Oil and The Stability Study
description	Essential oil of Curcuma mangga Val. has been reported to have cytotoxic effect against cancer cell lines. But this oil is unstable in dispensing so that a self nano-emulsifying drug delivery system (SNEDDS) of the oil was conducted to solve the problem and improve its potency. In the study, optimization, verification, characterization, and stability test of the SNEDDS formula were carried out respectively by simplex lattice design (SLD) on Design Expert ver. 10 software, droplet size and Zeta potential determinations using particle size analyzer (PSA) instrument, as well as heating-cooling and freeze-thaw methods. The best SNEDDS formula resulted was Miglyol : Tween 80 : PEG 400 = 16.034% : 68.380% : 15.586%; with transmittance of 84.47 + 1.05%, droplet size of 15.75 nm, zeta potential of -8.54 mV, polydispersity index (PDI) of 0.188, emulsifying time of 49.67 + 1.7 seconds in distilled water, 24.33 + 4.19 seconds in artificial gastric fluid and 21.33 + 2.87 seconds in artificial intestine fluid. After a freeze-thaw test there was no change on the emulsion’s clarity, color, smell, as well as no separation, which means that the formula was stable thermodynamically. The optimum SNEDDS formula resulted has small particle size, better emulsifying time in artificial gastric and intestine fluids, as well as better thermodynamic stability, which in turn will improve the cytotoxic activity of the Curcuma mangga Val. rhizome oil toward cancer cells.
format	article
author	Retno Sunarminingsih Sudibyo Lukman Mahdi Ronny Martien
author_facet	Retno Sunarminingsih Sudibyo Lukman Mahdi Ronny Martien
author_sort	Retno Sunarminingsih Sudibyo
title	Self Nano-Emulsifying Drug Delivery System (SNEDDS) of Curcuma Mangga Val. Essential Oil and The Stability Study
title_short	Self Nano-Emulsifying Drug Delivery System (SNEDDS) of Curcuma Mangga Val. Essential Oil and The Stability Study
title_full	Self Nano-Emulsifying Drug Delivery System (SNEDDS) of Curcuma Mangga Val. Essential Oil and The Stability Study
title_fullStr	Self Nano-Emulsifying Drug Delivery System (SNEDDS) of Curcuma Mangga Val. Essential Oil and The Stability Study
title_full_unstemmed	Self Nano-Emulsifying Drug Delivery System (SNEDDS) of Curcuma Mangga Val. Essential Oil and The Stability Study
title_sort	self nano-emulsifying drug delivery system (snedds) of curcuma mangga val. essential oil and the stability study
publisher	Universitas Gadjah Mada
publishDate	2020
url	https://doaj.org/article/2024311459b64cb3ac7c644d44eb78ba
work_keys_str_mv	AT retnosunarminingsihsudibyo selfnanoemulsifyingdrugdeliverysystemsneddsofcurcumamanggavalessentialoilandthestabilitystudy AT lukmanmahdi selfnanoemulsifyingdrugdeliverysystemsneddsofcurcumamanggavalessentialoilandthestabilitystudy AT ronnymartien selfnanoemulsifyingdrugdeliverysystemsneddsofcurcumamanggavalessentialoilandthestabilitystudy
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Self Nano-Emulsifying Drug Delivery System (SNEDDS) of Curcuma Mangga Val. Essential Oil and The Stability Study

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