Potential and clinical utility of stem cells in cardiovascular disease

Korff Krause, Carsten Schneider, Kai Jaquet, Karl-Heinz KuckHanseatic Heart Center Hamburg, Department of Cardiology, Asklepios Hospital St. Georg, Hamburg, GermanyAbstract: The recent identification of bone marrow-derived adult stem cells and other types of stem cells that could improve heart funct...

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Autores principales:	Korff Krause, Carsten Schneider, Kai Jaquet, et al
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2010
Materias:	Cytology QH573-671
Acceso en línea:	https://doaj.org/article/2024976ecdf54d83ad55dea15a9b1270
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spelling	oai:doaj.org-article:2024976ecdf54d83ad55dea15a9b12702021-12-02T01:19:31ZPotential and clinical utility of stem cells in cardiovascular disease1178-6957https://doaj.org/article/2024976ecdf54d83ad55dea15a9b12702010-03-01T00:00:00Zhttp://www.dovepress.com/potential-and-clinical-utility-of-stem-cells-in-cardiovascular-disease-a4141https://doaj.org/toc/1178-6957Korff Krause, Carsten Schneider, Kai Jaquet, Karl-Heinz KuckHanseatic Heart Center Hamburg, Department of Cardiology, Asklepios Hospital St. Georg, Hamburg, GermanyAbstract: The recent identification of bone marrow-derived adult stem cells and other types of stem cells that could improve heart function after transplantation have raised high expectations. The basic mechanisms have been studied mostly in murine models. However, these experiments revealed controversial results on transdifferentiation vs transfusion of adult stem cells vs paracrine effects of these cells, which is still being debated. Moreover, the reproducibility of these results in precisely translated large animal models is still less well investigated. Despite these weaknesses results of several clinical trials including several hundreds of patients with ischemic heart disease have been published. However, there are no solid data showing that any of these approaches can regenerate human myocardium. Even the effectiveness of cell therapy in these approaches is doubtful. In future we need in this important field of regenerative medicine: i) more experimental data in large animals that are closer to the anatomy and physiology of humans, including data on dose effects, comparison of different cell types and different delivery routes; ii) a better understanding of the molecular mechanisms involved in the fate of transplanted cells; iii) more intensive research on genuine regenerative medicine, applying genetic regulation and cell engineering.Keywords: stem cells, cardiovascular disease Korff KrauseCarsten SchneiderKai Jaquetet alDove Medical PressarticleCytologyQH573-671ENStem Cells and Cloning: Advances and Applications, Vol 2010, Iss default, Pp 49-56 (2010)
institution	DOAJ
collection	DOAJ
language	EN
topic	Cytology QH573-671
spellingShingle	Cytology QH573-671 Korff Krause Carsten Schneider Kai Jaquet et al Potential and clinical utility of stem cells in cardiovascular disease
description	Korff Krause, Carsten Schneider, Kai Jaquet, Karl-Heinz KuckHanseatic Heart Center Hamburg, Department of Cardiology, Asklepios Hospital St. Georg, Hamburg, GermanyAbstract: The recent identification of bone marrow-derived adult stem cells and other types of stem cells that could improve heart function after transplantation have raised high expectations. The basic mechanisms have been studied mostly in murine models. However, these experiments revealed controversial results on transdifferentiation vs transfusion of adult stem cells vs paracrine effects of these cells, which is still being debated. Moreover, the reproducibility of these results in precisely translated large animal models is still less well investigated. Despite these weaknesses results of several clinical trials including several hundreds of patients with ischemic heart disease have been published. However, there are no solid data showing that any of these approaches can regenerate human myocardium. Even the effectiveness of cell therapy in these approaches is doubtful. In future we need in this important field of regenerative medicine: i) more experimental data in large animals that are closer to the anatomy and physiology of humans, including data on dose effects, comparison of different cell types and different delivery routes; ii) a better understanding of the molecular mechanisms involved in the fate of transplanted cells; iii) more intensive research on genuine regenerative medicine, applying genetic regulation and cell engineering.Keywords: stem cells, cardiovascular disease
format	article
author	Korff Krause Carsten Schneider Kai Jaquet et al
author_facet	Korff Krause Carsten Schneider Kai Jaquet et al
author_sort	Korff Krause
title	Potential and clinical utility of stem cells in cardiovascular disease
title_short	Potential and clinical utility of stem cells in cardiovascular disease
title_full	Potential and clinical utility of stem cells in cardiovascular disease
title_fullStr	Potential and clinical utility of stem cells in cardiovascular disease
title_full_unstemmed	Potential and clinical utility of stem cells in cardiovascular disease
title_sort	potential and clinical utility of stem cells in cardiovascular disease
publisher	Dove Medical Press
publishDate	2010
url	https://doaj.org/article/2024976ecdf54d83ad55dea15a9b1270
work_keys_str_mv	AT korffkrause potentialandclinicalutilityofstemcellsincardiovasculardisease AT carstenschneider potentialandclinicalutilityofstemcellsincardiovasculardisease AT kaijaquet potentialandclinicalutilityofstemcellsincardiovasculardisease AT etal potentialandclinicalutilityofstemcellsincardiovasculardisease
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Potential and clinical utility of stem cells in cardiovascular disease

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