Polymer-Coated Nanoparticles for Therapeutic and Diagnostic Non-<sup>10</sup>B Enriched Polymer-Coated Boron Carbon Oxynitride (BCNO) Nanoparticles as Potent BNCT Drug

Boron neutron capture therapy (BNCT) is a powerful and selective anti-cancer therapy utilizing <sup>10</sup>B-enriched boron drugs. However, clinical advancement of BCNT is hampered by the insufficient loading of B-10 drugs throughout the solid tumor. Furthermore, the preparation of boro...

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Autores principales:	Chen-Wei Chiang, Yun-Chen Chien, Wen-Jui Yu, Chia-Yu Ho, Chih-Yi Wang, Tzu-Wei Wang, Chi-Shiun Chiang, Pei-Yuin Keng
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	BNCT BCNO cancer therapy nanoparticle drug delivery Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/2027207dac3a47ada20ea18d847578b9
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spelling	oai:doaj.org-article:2027207dac3a47ada20ea18d847578b92021-11-25T18:30:58ZPolymer-Coated Nanoparticles for Therapeutic and Diagnostic Non-<sup>10</sup>B Enriched Polymer-Coated Boron Carbon Oxynitride (BCNO) Nanoparticles as Potent BNCT Drug10.3390/nano111129362079-4991https://doaj.org/article/2027207dac3a47ada20ea18d847578b92021-11-01T00:00:00Zhttps://www.mdpi.com/2079-4991/11/11/2936https://doaj.org/toc/2079-4991Boron neutron capture therapy (BNCT) is a powerful and selective anti-cancer therapy utilizing <sup>10</sup>B-enriched boron drugs. However, clinical advancement of BCNT is hampered by the insufficient loading of B-10 drugs throughout the solid tumor. Furthermore, the preparation of boron drugs for BNCT relies on the use of the costly B-10 enriched precursor. To overcome these challenges, polymer-coated boron carbon oxynitride (BCNO) nanoparticles, with ~30% of boron, were developed with enhanced biocompatibility, cell uptake, and tumoricidal effect via BNCT. Using the ALTS1C1 cancer cell line, the IC<sub>50</sub> of the PEG@BCNO, bare, PEI@BCNO were determined to be 0.3 mg/mL, 0.1 mg/mL, and 0.05 mg/mL, respectively. As a proof-of-concept, the engineered non-<sup>10</sup>B enriched polymer-coated BCNO exhibited excellent anti-tumor effect via BNCT due to their high boron content per nanoparticle and due to the enhanced cellular internalization and retention compared to small molecular <sup>10</sup>B-BPA drug. The astrocytoma ALTS1C1 cells treated with bare, polyethyleneimine-, and polyethylene glycol-coated BCNO exhibited an acute cell death of 24, 37, and 43%, respectively, upon 30 min of neutron irradiation compared to the negligible cell death in PBS-treated and non-irradiated cells. The radical approach proposed in this study addresses the expensive and complex issues of B-10 isotope enrichment process; thus, enabling the preparation of boron drugs at a significantly lower cost, which will facilitate the development of boron drugs for BNCT.Chen-Wei ChiangYun-Chen ChienWen-Jui YuChia-Yu HoChih-Yi WangTzu-Wei WangChi-Shiun ChiangPei-Yuin KengMDPI AGarticleBNCTBCNOcancer therapynanoparticle drug deliveryChemistryQD1-999ENNanomaterials, Vol 11, Iss 2936, p 2936 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	BNCT BCNO cancer therapy nanoparticle drug delivery Chemistry QD1-999
spellingShingle	BNCT BCNO cancer therapy nanoparticle drug delivery Chemistry QD1-999 Chen-Wei Chiang Yun-Chen Chien Wen-Jui Yu Chia-Yu Ho Chih-Yi Wang Tzu-Wei Wang Chi-Shiun Chiang Pei-Yuin Keng Polymer-Coated Nanoparticles for Therapeutic and Diagnostic Non-<sup>10</sup>B Enriched Polymer-Coated Boron Carbon Oxynitride (BCNO) Nanoparticles as Potent BNCT Drug
description	Boron neutron capture therapy (BNCT) is a powerful and selective anti-cancer therapy utilizing <sup>10</sup>B-enriched boron drugs. However, clinical advancement of BCNT is hampered by the insufficient loading of B-10 drugs throughout the solid tumor. Furthermore, the preparation of boron drugs for BNCT relies on the use of the costly B-10 enriched precursor. To overcome these challenges, polymer-coated boron carbon oxynitride (BCNO) nanoparticles, with ~30% of boron, were developed with enhanced biocompatibility, cell uptake, and tumoricidal effect via BNCT. Using the ALTS1C1 cancer cell line, the IC<sub>50</sub> of the PEG@BCNO, bare, PEI@BCNO were determined to be 0.3 mg/mL, 0.1 mg/mL, and 0.05 mg/mL, respectively. As a proof-of-concept, the engineered non-<sup>10</sup>B enriched polymer-coated BCNO exhibited excellent anti-tumor effect via BNCT due to their high boron content per nanoparticle and due to the enhanced cellular internalization and retention compared to small molecular <sup>10</sup>B-BPA drug. The astrocytoma ALTS1C1 cells treated with bare, polyethyleneimine-, and polyethylene glycol-coated BCNO exhibited an acute cell death of 24, 37, and 43%, respectively, upon 30 min of neutron irradiation compared to the negligible cell death in PBS-treated and non-irradiated cells. The radical approach proposed in this study addresses the expensive and complex issues of B-10 isotope enrichment process; thus, enabling the preparation of boron drugs at a significantly lower cost, which will facilitate the development of boron drugs for BNCT.
format	article
author	Chen-Wei Chiang Yun-Chen Chien Wen-Jui Yu Chia-Yu Ho Chih-Yi Wang Tzu-Wei Wang Chi-Shiun Chiang Pei-Yuin Keng
author_facet	Chen-Wei Chiang Yun-Chen Chien Wen-Jui Yu Chia-Yu Ho Chih-Yi Wang Tzu-Wei Wang Chi-Shiun Chiang Pei-Yuin Keng
author_sort	Chen-Wei Chiang
title	Polymer-Coated Nanoparticles for Therapeutic and Diagnostic Non-<sup>10</sup>B Enriched Polymer-Coated Boron Carbon Oxynitride (BCNO) Nanoparticles as Potent BNCT Drug
title_short	Polymer-Coated Nanoparticles for Therapeutic and Diagnostic Non-<sup>10</sup>B Enriched Polymer-Coated Boron Carbon Oxynitride (BCNO) Nanoparticles as Potent BNCT Drug
title_full	Polymer-Coated Nanoparticles for Therapeutic and Diagnostic Non-<sup>10</sup>B Enriched Polymer-Coated Boron Carbon Oxynitride (BCNO) Nanoparticles as Potent BNCT Drug
title_fullStr	Polymer-Coated Nanoparticles for Therapeutic and Diagnostic Non-<sup>10</sup>B Enriched Polymer-Coated Boron Carbon Oxynitride (BCNO) Nanoparticles as Potent BNCT Drug
title_full_unstemmed	Polymer-Coated Nanoparticles for Therapeutic and Diagnostic Non-<sup>10</sup>B Enriched Polymer-Coated Boron Carbon Oxynitride (BCNO) Nanoparticles as Potent BNCT Drug
title_sort	polymer-coated nanoparticles for therapeutic and diagnostic non-<sup>10</sup>b enriched polymer-coated boron carbon oxynitride (bcno) nanoparticles as potent bnct drug
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/2027207dac3a47ada20ea18d847578b9
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Polymer-Coated Nanoparticles for Therapeutic and Diagnostic Non-<sup>10</sup>B Enriched Polymer-Coated Boron Carbon Oxynitride (BCNO) Nanoparticles as Potent BNCT Drug

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