Determination of ROS Scavenging, Antibacterial and Antifungal Potential of Methanolic Extract of <i>Otostegia limbata</i> (Benth.) Boiss.
Wide spectrum medicinal significance augments plant utilization as the primary source of significant pharmaceutical agents. In vitro investigation of antioxidant and antimicrobial activity highlights the therapeutic potential of <i>Otostegia limbata</i>. Methanol extract of the plant (ME...
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| Autores principales: | , , , , , , , , |
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| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
MDPI AG
2021
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| Materias: | |
| Acceso en línea: | https://doaj.org/article/202bcbb9cb5e46f7b40d81878f1b937f |
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| Sumario: | Wide spectrum medicinal significance augments plant utilization as the primary source of significant pharmaceutical agents. In vitro investigation of antioxidant and antimicrobial activity highlights the therapeutic potential of <i>Otostegia limbata</i>. Methanol extract of the plant (MEP) shows considerable dose dependent antioxidant ability at six concentrations (7.81 µg/mL to 250 µg/mL) in 2.2-diphenyl-1-picrylhydrazyl (DPPH) assay, phosphomolybdate assay (PMA) and reducing power assay (RPA). The plant capability to scavenge free radicals in the mixture ranged from 37.89% to 63.50% in a concentration-dependent manner. MEP was active against five tested bacterial strains in the agar-well diffusion method. <i>Staphylococcus aureus</i>, gram-positive bacteria was found to be most susceptible followed by <i>S. epidermidis</i> with 18.80 mm and 17.47 mm mean zone of inhibition. The mean inhibition zone against gram-negative strains <i>Klebsiella pneumonia</i>, <i>Pseudomonas</i> spp. and <i>Escherichia coli</i> were 15.07 mm, 14.73 mm, and 12.17 mm. MEP revealed potential against <i>Alternaria</i> spp. and <i>Aspergillus terreus</i> fungal strains evaluated through agar-tube dilution assay. <i>Aspergillus terreus</i> was more sensitive than <i>Alternaria</i> spp. with an average 78.45% and 68.0% inhibition. These findings can serve as a benchmark for forthcoming scrutiny such as bioactive components discovery and drug development. |
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