Silybum marianum seed disrupts mitosis by reducing polo-like kinase 1 in breast cancer cells

Background: Silybum marianum (SM) seeds contain a family of flavonolignans. Many studies have revealed the role of SM in regulating cancer cell proliferation and apoptosis, but research has rarely focused on the correlation between cancer cell regulation and SM seed (SMS). Breast cancer is the most...

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Autores principales:	Hsing-Yu Jao, Fang-Rong Chang, Chun-Wen Cheng, Hsin-Wen Liang, Chau-Jong Wang, Huei-Jane Lee
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2022
Materias:	Silybum marianum seed Breast cancer Mitosis Polo-like kinase Cell cycle Other systems of medicine RZ201-999
Acceso en línea:	https://doaj.org/article/202c660e7d814b14870e27c0f7790041
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spelling	oai:doaj.org-article:202c660e7d814b14870e27c0f77900412021-11-26T04:42:39ZSilybum marianum seed disrupts mitosis by reducing polo-like kinase 1 in breast cancer cells2667-031310.1016/j.phyplu.2021.100164https://doaj.org/article/202c660e7d814b14870e27c0f77900412022-02-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2667031321001469https://doaj.org/toc/2667-0313Background: Silybum marianum (SM) seeds contain a family of flavonolignans. Many studies have revealed the role of SM in regulating cancer cell proliferation and apoptosis, but research has rarely focused on the correlation between cancer cell regulation and SM seed (SMS). Breast cancer is the most commonly diagnosed cancer in women worldwide. In addition to clinical treatments, natural products reportedly act as auxiliary agents or treatments for breast cancer. Purpose: This study investigated the effect of SMS water extract (SMSWE) on breast cancer and explored the potential molecular mechanism of its effect. Methods: We used SMSWE to treat breast cancer cells and animals orthotopically injected with breast cancer cells. Results: The results indicated that SMSWE decreased breast cancer cell viability by disrupting mitosis. The mechanism was modulated by the downregulation of proteins involved in spindle assembly, including polo-like kinase 1 (PLK1) and the EXTAH complex (Eg5, XMAP215, Tpx2, Aurora A, and HURP). In mice orthotopically injected with breast cancer cells and treated with SMSWE, tumor growth significantly decreased and PLK1 expression decreased compared with controls. Conclusions: These current evidences provide that SMSWE treatment can decelerate breast cancer cell growth, and the possible mechanism involves mitosis disruption through decreased PLK1 expression.Hsing-Yu JaoFang-Rong ChangChun-Wen ChengHsin-Wen LiangChau-Jong WangHuei-Jane LeeElsevierarticleSilybum marianum seedBreast cancerMitosisPolo-like kinaseCell cycleOther systems of medicineRZ201-999ENPhytomedicine Plus, Vol 2, Iss 1, Pp 100164- (2022)
institution	DOAJ
collection	DOAJ
language	EN
topic	Silybum marianum seed Breast cancer Mitosis Polo-like kinase Cell cycle Other systems of medicine RZ201-999
spellingShingle	Silybum marianum seed Breast cancer Mitosis Polo-like kinase Cell cycle Other systems of medicine RZ201-999 Hsing-Yu Jao Fang-Rong Chang Chun-Wen Cheng Hsin-Wen Liang Chau-Jong Wang Huei-Jane Lee Silybum marianum seed disrupts mitosis by reducing polo-like kinase 1 in breast cancer cells
description	Background: Silybum marianum (SM) seeds contain a family of flavonolignans. Many studies have revealed the role of SM in regulating cancer cell proliferation and apoptosis, but research has rarely focused on the correlation between cancer cell regulation and SM seed (SMS). Breast cancer is the most commonly diagnosed cancer in women worldwide. In addition to clinical treatments, natural products reportedly act as auxiliary agents or treatments for breast cancer. Purpose: This study investigated the effect of SMS water extract (SMSWE) on breast cancer and explored the potential molecular mechanism of its effect. Methods: We used SMSWE to treat breast cancer cells and animals orthotopically injected with breast cancer cells. Results: The results indicated that SMSWE decreased breast cancer cell viability by disrupting mitosis. The mechanism was modulated by the downregulation of proteins involved in spindle assembly, including polo-like kinase 1 (PLK1) and the EXTAH complex (Eg5, XMAP215, Tpx2, Aurora A, and HURP). In mice orthotopically injected with breast cancer cells and treated with SMSWE, tumor growth significantly decreased and PLK1 expression decreased compared with controls. Conclusions: These current evidences provide that SMSWE treatment can decelerate breast cancer cell growth, and the possible mechanism involves mitosis disruption through decreased PLK1 expression.
format	article
author	Hsing-Yu Jao Fang-Rong Chang Chun-Wen Cheng Hsin-Wen Liang Chau-Jong Wang Huei-Jane Lee
author_facet	Hsing-Yu Jao Fang-Rong Chang Chun-Wen Cheng Hsin-Wen Liang Chau-Jong Wang Huei-Jane Lee
author_sort	Hsing-Yu Jao
title	Silybum marianum seed disrupts mitosis by reducing polo-like kinase 1 in breast cancer cells
title_short	Silybum marianum seed disrupts mitosis by reducing polo-like kinase 1 in breast cancer cells
title_full	Silybum marianum seed disrupts mitosis by reducing polo-like kinase 1 in breast cancer cells
title_fullStr	Silybum marianum seed disrupts mitosis by reducing polo-like kinase 1 in breast cancer cells
title_full_unstemmed	Silybum marianum seed disrupts mitosis by reducing polo-like kinase 1 in breast cancer cells
title_sort	silybum marianum seed disrupts mitosis by reducing polo-like kinase 1 in breast cancer cells
publisher	Elsevier
publishDate	2022
url	https://doaj.org/article/202c660e7d814b14870e27c0f7790041
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Silybum marianum seed disrupts mitosis by reducing polo-like kinase 1 in breast cancer cells

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