Persistence of viral RNA in lymph nodes in ART-suppressed SIV/SHIV-infected Rhesus Macaques

The existence of HIV reservoir and ongoing replication despite antiretroviral therapy (ART) represents a barrier for cure efforts. Here, using SIV/SHIV-infected rhesus macaque suppressed with ART for one year, the authors characterize multiple lymphoid and non-lymphoid tissues and show that while th...

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Autores principales:	Anthony M. Cadena, John D. Ventura, Peter Abbink, Erica N. Borducchi, Hubert Tuyishime, Noe B. Mercado, Victoria Walker-Sperling, Mazuba Siamatu, Po-Ting Liu, Abishek Chandrashekar, Joseph P. Nkolola, Katherine McMahan, Nicole Kordana, Venous Hamza, Esther A. Bondzie, Emily Fray, Mithra Kumar, Stephanie Fischinger, Sally A. Shin, Mark G. Lewis, Robert F. Siliciano, Galit Alter, Dan H. Barouch
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/202e143cd50c4ecea53a829693bdf039
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spelling	oai:doaj.org-article:202e143cd50c4ecea53a829693bdf0392021-12-02T13:32:50ZPersistence of viral RNA in lymph nodes in ART-suppressed SIV/SHIV-infected Rhesus Macaques10.1038/s41467-021-21724-02041-1723https://doaj.org/article/202e143cd50c4ecea53a829693bdf0392021-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21724-0https://doaj.org/toc/2041-1723The existence of HIV reservoir and ongoing replication despite antiretroviral therapy (ART) represents a barrier for cure efforts. Here, using SIV/SHIV-infected rhesus macaque suppressed with ART for one year, the authors characterize multiple lymphoid and non-lymphoid tissues and show that while the viral reservoir exhibits a wide anatomic heterogeneity, persistent viral transcription is mainly restricted to secondary lymphoid organs.Anthony M. CadenaJohn D. VenturaPeter AbbinkErica N. BorducchiHubert TuyishimeNoe B. MercadoVictoria Walker-SperlingMazuba SiamatuPo-Ting LiuAbishek ChandrashekarJoseph P. NkololaKatherine McMahanNicole KordanaVenous HamzaEsther A. BondzieEmily FrayMithra KumarStephanie FischingerSally A. ShinMark G. LewisRobert F. SilicianoGalit AlterDan H. BarouchNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Anthony M. Cadena John D. Ventura Peter Abbink Erica N. Borducchi Hubert Tuyishime Noe B. Mercado Victoria Walker-Sperling Mazuba Siamatu Po-Ting Liu Abishek Chandrashekar Joseph P. Nkolola Katherine McMahan Nicole Kordana Venous Hamza Esther A. Bondzie Emily Fray Mithra Kumar Stephanie Fischinger Sally A. Shin Mark G. Lewis Robert F. Siliciano Galit Alter Dan H. Barouch Persistence of viral RNA in lymph nodes in ART-suppressed SIV/SHIV-infected Rhesus Macaques
description	The existence of HIV reservoir and ongoing replication despite antiretroviral therapy (ART) represents a barrier for cure efforts. Here, using SIV/SHIV-infected rhesus macaque suppressed with ART for one year, the authors characterize multiple lymphoid and non-lymphoid tissues and show that while the viral reservoir exhibits a wide anatomic heterogeneity, persistent viral transcription is mainly restricted to secondary lymphoid organs.
format	article
author	Anthony M. Cadena John D. Ventura Peter Abbink Erica N. Borducchi Hubert Tuyishime Noe B. Mercado Victoria Walker-Sperling Mazuba Siamatu Po-Ting Liu Abishek Chandrashekar Joseph P. Nkolola Katherine McMahan Nicole Kordana Venous Hamza Esther A. Bondzie Emily Fray Mithra Kumar Stephanie Fischinger Sally A. Shin Mark G. Lewis Robert F. Siliciano Galit Alter Dan H. Barouch
author_facet	Anthony M. Cadena John D. Ventura Peter Abbink Erica N. Borducchi Hubert Tuyishime Noe B. Mercado Victoria Walker-Sperling Mazuba Siamatu Po-Ting Liu Abishek Chandrashekar Joseph P. Nkolola Katherine McMahan Nicole Kordana Venous Hamza Esther A. Bondzie Emily Fray Mithra Kumar Stephanie Fischinger Sally A. Shin Mark G. Lewis Robert F. Siliciano Galit Alter Dan H. Barouch
author_sort	Anthony M. Cadena
title	Persistence of viral RNA in lymph nodes in ART-suppressed SIV/SHIV-infected Rhesus Macaques
title_short	Persistence of viral RNA in lymph nodes in ART-suppressed SIV/SHIV-infected Rhesus Macaques
title_full	Persistence of viral RNA in lymph nodes in ART-suppressed SIV/SHIV-infected Rhesus Macaques
title_fullStr	Persistence of viral RNA in lymph nodes in ART-suppressed SIV/SHIV-infected Rhesus Macaques
title_full_unstemmed	Persistence of viral RNA in lymph nodes in ART-suppressed SIV/SHIV-infected Rhesus Macaques
title_sort	persistence of viral rna in lymph nodes in art-suppressed siv/shiv-infected rhesus macaques
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/202e143cd50c4ecea53a829693bdf039
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Persistence of viral RNA in lymph nodes in ART-suppressed SIV/SHIV-infected Rhesus Macaques

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