Transcriptional profiling of mESC-derived tendon and fibrocartilage cell fate switch
The transcriptional regulators underlying the induction and differentiation of dense connective tissues remain largely unknown. Here the authors generate tendon and fibrocartilage cells from mouse embryonic stem cells and apply scRNA-seq to identify molecular regulation of the cell fate switch betwe...
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Nature Portfolio
2021
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oai:doaj.org-article:202f13cacd374532a04807c316148c572021-12-02T16:14:49ZTranscriptional profiling of mESC-derived tendon and fibrocartilage cell fate switch10.1038/s41467-021-24535-52041-1723https://doaj.org/article/202f13cacd374532a04807c316148c572021-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24535-5https://doaj.org/toc/2041-1723The transcriptional regulators underlying the induction and differentiation of dense connective tissues remain largely unknown. Here the authors generate tendon and fibrocartilage cells from mouse embryonic stem cells and apply scRNA-seq to identify molecular regulation of the cell fate switch between these lineages.Deepak A. KajiAngela M. MonteroRoosheel PatelAlice H. HuangNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-16 (2021) |
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Science Q Deepak A. Kaji Angela M. Montero Roosheel Patel Alice H. Huang Transcriptional profiling of mESC-derived tendon and fibrocartilage cell fate switch |
description |
The transcriptional regulators underlying the induction and differentiation of dense connective tissues remain largely unknown. Here the authors generate tendon and fibrocartilage cells from mouse embryonic stem cells and apply scRNA-seq to identify molecular regulation of the cell fate switch between these lineages. |
format |
article |
author |
Deepak A. Kaji Angela M. Montero Roosheel Patel Alice H. Huang |
author_facet |
Deepak A. Kaji Angela M. Montero Roosheel Patel Alice H. Huang |
author_sort |
Deepak A. Kaji |
title |
Transcriptional profiling of mESC-derived tendon and fibrocartilage cell fate switch |
title_short |
Transcriptional profiling of mESC-derived tendon and fibrocartilage cell fate switch |
title_full |
Transcriptional profiling of mESC-derived tendon and fibrocartilage cell fate switch |
title_fullStr |
Transcriptional profiling of mESC-derived tendon and fibrocartilage cell fate switch |
title_full_unstemmed |
Transcriptional profiling of mESC-derived tendon and fibrocartilage cell fate switch |
title_sort |
transcriptional profiling of mesc-derived tendon and fibrocartilage cell fate switch |
publisher |
Nature Portfolio |
publishDate |
2021 |
url |
https://doaj.org/article/202f13cacd374532a04807c316148c57 |
work_keys_str_mv |
AT deepakakaji transcriptionalprofilingofmescderivedtendonandfibrocartilagecellfateswitch AT angelammontero transcriptionalprofilingofmescderivedtendonandfibrocartilagecellfateswitch AT roosheelpatel transcriptionalprofilingofmescderivedtendonandfibrocartilagecellfateswitch AT alicehhuang transcriptionalprofilingofmescderivedtendonandfibrocartilagecellfateswitch |
_version_ |
1718384278435266560 |