Transcriptional profiling of mESC-derived tendon and fibrocartilage cell fate switch

The transcriptional regulators underlying the induction and differentiation of dense connective tissues remain largely unknown. Here the authors generate tendon and fibrocartilage cells from mouse embryonic stem cells and apply scRNA-seq to identify molecular regulation of the cell fate switch betwe...

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Autores principales: Deepak A. Kaji, Angela M. Montero, Roosheel Patel, Alice H. Huang
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/202f13cacd374532a04807c316148c57
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spelling oai:doaj.org-article:202f13cacd374532a04807c316148c572021-12-02T16:14:49ZTranscriptional profiling of mESC-derived tendon and fibrocartilage cell fate switch10.1038/s41467-021-24535-52041-1723https://doaj.org/article/202f13cacd374532a04807c316148c572021-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24535-5https://doaj.org/toc/2041-1723The transcriptional regulators underlying the induction and differentiation of dense connective tissues remain largely unknown. Here the authors generate tendon and fibrocartilage cells from mouse embryonic stem cells and apply scRNA-seq to identify molecular regulation of the cell fate switch between these lineages.Deepak A. KajiAngela M. MonteroRoosheel PatelAlice H. HuangNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Deepak A. Kaji
Angela M. Montero
Roosheel Patel
Alice H. Huang
Transcriptional profiling of mESC-derived tendon and fibrocartilage cell fate switch
description The transcriptional regulators underlying the induction and differentiation of dense connective tissues remain largely unknown. Here the authors generate tendon and fibrocartilage cells from mouse embryonic stem cells and apply scRNA-seq to identify molecular regulation of the cell fate switch between these lineages.
format article
author Deepak A. Kaji
Angela M. Montero
Roosheel Patel
Alice H. Huang
author_facet Deepak A. Kaji
Angela M. Montero
Roosheel Patel
Alice H. Huang
author_sort Deepak A. Kaji
title Transcriptional profiling of mESC-derived tendon and fibrocartilage cell fate switch
title_short Transcriptional profiling of mESC-derived tendon and fibrocartilage cell fate switch
title_full Transcriptional profiling of mESC-derived tendon and fibrocartilage cell fate switch
title_fullStr Transcriptional profiling of mESC-derived tendon and fibrocartilage cell fate switch
title_full_unstemmed Transcriptional profiling of mESC-derived tendon and fibrocartilage cell fate switch
title_sort transcriptional profiling of mesc-derived tendon and fibrocartilage cell fate switch
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/202f13cacd374532a04807c316148c57
work_keys_str_mv AT deepakakaji transcriptionalprofilingofmescderivedtendonandfibrocartilagecellfateswitch
AT angelammontero transcriptionalprofilingofmescderivedtendonandfibrocartilagecellfateswitch
AT roosheelpatel transcriptionalprofilingofmescderivedtendonandfibrocartilagecellfateswitch
AT alicehhuang transcriptionalprofilingofmescderivedtendonandfibrocartilagecellfateswitch
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