Hydrophobic pore gates regulate ion permeation in polycystic kidney disease 2 and 2L1 channels

Mutations in the cation channel PKD2 cause human autosomal dominant polycystic kidney disease but its channel function and gating mechanism are poorly understood. Here authors study PKD2 using electrophysiology and cryo-EM, which identifies hydrophobic gates and proposes a gating mechanism for PKD2.

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Autores principales:	Wang Zheng, Xiaoyong Yang, Ruikun Hu, Ruiqi Cai, Laura Hofmann, Zhifei Wang, Qiaolin Hu, Xiong Liu, David Bulkley, Yong Yu, Jingfeng Tang, Veit Flockerzi, Ying Cao, Erhu Cao, Xing-Zhen Chen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/20301d3296ff4b26990052a93df36ef3
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spelling	oai:doaj.org-article:20301d3296ff4b26990052a93df36ef32021-12-02T16:49:56ZHydrophobic pore gates regulate ion permeation in polycystic kidney disease 2 and 2L1 channels10.1038/s41467-018-04586-x2041-1723https://doaj.org/article/20301d3296ff4b26990052a93df36ef32018-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04586-xhttps://doaj.org/toc/2041-1723Mutations in the cation channel PKD2 cause human autosomal dominant polycystic kidney disease but its channel function and gating mechanism are poorly understood. Here authors study PKD2 using electrophysiology and cryo-EM, which identifies hydrophobic gates and proposes a gating mechanism for PKD2.Wang ZhengXiaoyong YangRuikun HuRuiqi CaiLaura HofmannZhifei WangQiaolin HuXiong LiuDavid BulkleyYong YuJingfeng TangVeit FlockerziYing CaoErhu CaoXing-Zhen ChenNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Wang Zheng Xiaoyong Yang Ruikun Hu Ruiqi Cai Laura Hofmann Zhifei Wang Qiaolin Hu Xiong Liu David Bulkley Yong Yu Jingfeng Tang Veit Flockerzi Ying Cao Erhu Cao Xing-Zhen Chen Hydrophobic pore gates regulate ion permeation in polycystic kidney disease 2 and 2L1 channels
description	Mutations in the cation channel PKD2 cause human autosomal dominant polycystic kidney disease but its channel function and gating mechanism are poorly understood. Here authors study PKD2 using electrophysiology and cryo-EM, which identifies hydrophobic gates and proposes a gating mechanism for PKD2.
format	article
author	Wang Zheng Xiaoyong Yang Ruikun Hu Ruiqi Cai Laura Hofmann Zhifei Wang Qiaolin Hu Xiong Liu David Bulkley Yong Yu Jingfeng Tang Veit Flockerzi Ying Cao Erhu Cao Xing-Zhen Chen
author_facet	Wang Zheng Xiaoyong Yang Ruikun Hu Ruiqi Cai Laura Hofmann Zhifei Wang Qiaolin Hu Xiong Liu David Bulkley Yong Yu Jingfeng Tang Veit Flockerzi Ying Cao Erhu Cao Xing-Zhen Chen
author_sort	Wang Zheng
title	Hydrophobic pore gates regulate ion permeation in polycystic kidney disease 2 and 2L1 channels
title_short	Hydrophobic pore gates regulate ion permeation in polycystic kidney disease 2 and 2L1 channels
title_full	Hydrophobic pore gates regulate ion permeation in polycystic kidney disease 2 and 2L1 channels
title_fullStr	Hydrophobic pore gates regulate ion permeation in polycystic kidney disease 2 and 2L1 channels
title_full_unstemmed	Hydrophobic pore gates regulate ion permeation in polycystic kidney disease 2 and 2L1 channels
title_sort	hydrophobic pore gates regulate ion permeation in polycystic kidney disease 2 and 2l1 channels
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/20301d3296ff4b26990052a93df36ef3
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_version_	1718383143450312704

Hydrophobic pore gates regulate ion permeation in polycystic kidney disease 2 and 2L1 channels

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