Genetic evidence of an East Asian origin and paleolithic northward migration of Y-chromosome haplogroup N.

The Y-chromosome haplogroup N-M231 (Hg N) is distributed widely in eastern and central Asia, Siberia, as well as in eastern and northern Europe. Previous studies suggested a counterclockwise prehistoric migration of Hg N from eastern Asia to eastern and northern Europe. However, the root of this Y c...

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Autores principales:	Hong Shi, Xuebin Qi, Hua Zhong, Yi Peng, Xiaoming Zhang, Runlin Z Ma, Bing Su
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/2031e9a4206147c2b6ab020c75b578e9
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spelling	oai:doaj.org-article:2031e9a4206147c2b6ab020c75b578e92021-11-18T07:40:50ZGenetic evidence of an East Asian origin and paleolithic northward migration of Y-chromosome haplogroup N.1932-620310.1371/journal.pone.0066102https://doaj.org/article/2031e9a4206147c2b6ab020c75b578e92013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23840409/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203The Y-chromosome haplogroup N-M231 (Hg N) is distributed widely in eastern and central Asia, Siberia, as well as in eastern and northern Europe. Previous studies suggested a counterclockwise prehistoric migration of Hg N from eastern Asia to eastern and northern Europe. However, the root of this Y chromosome lineage and its detailed dispersal pattern across eastern Asia are still unclear. We analyzed haplogroup profiles and phylogeographic patterns of 1,570 Hg N individuals from 20,826 males in 359 populations across Eurasia. We first genotyped 6,371 males from 169 populations in China and Cambodia, and generated data of 360 Hg N individuals, and then combined published data on 1,210 Hg N individuals from Japanese, Southeast Asian, Siberian, European and Central Asian populations. The results showed that the sub-haplogroups of Hg N have a distinct geographical distribution. The highest Y-STR diversity of the ancestral Hg N sub-haplogroups was observed in the southern part of mainland East Asia, and further phylogeographic analyses supports an origin of Hg N in southern China. Combined with previous data, we propose that the early northward dispersal of Hg N started from southern China about 21 thousand years ago (kya), expanding into northern China 12-18 kya, and reaching further north to Siberia about 12-14 kya before a population expansion and westward migration into Central Asia and eastern/northern Europe around 8.0-10.0 kya. This northward migration of Hg N likewise coincides with retreating ice sheets after the Last Glacial Maximum (22-18 kya) in mainland East Asia.Hong ShiXuebin QiHua ZhongYi PengXiaoming ZhangRunlin Z MaBing SuPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 6, p e66102 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Hong Shi Xuebin Qi Hua Zhong Yi Peng Xiaoming Zhang Runlin Z Ma Bing Su Genetic evidence of an East Asian origin and paleolithic northward migration of Y-chromosome haplogroup N.
description	The Y-chromosome haplogroup N-M231 (Hg N) is distributed widely in eastern and central Asia, Siberia, as well as in eastern and northern Europe. Previous studies suggested a counterclockwise prehistoric migration of Hg N from eastern Asia to eastern and northern Europe. However, the root of this Y chromosome lineage and its detailed dispersal pattern across eastern Asia are still unclear. We analyzed haplogroup profiles and phylogeographic patterns of 1,570 Hg N individuals from 20,826 males in 359 populations across Eurasia. We first genotyped 6,371 males from 169 populations in China and Cambodia, and generated data of 360 Hg N individuals, and then combined published data on 1,210 Hg N individuals from Japanese, Southeast Asian, Siberian, European and Central Asian populations. The results showed that the sub-haplogroups of Hg N have a distinct geographical distribution. The highest Y-STR diversity of the ancestral Hg N sub-haplogroups was observed in the southern part of mainland East Asia, and further phylogeographic analyses supports an origin of Hg N in southern China. Combined with previous data, we propose that the early northward dispersal of Hg N started from southern China about 21 thousand years ago (kya), expanding into northern China 12-18 kya, and reaching further north to Siberia about 12-14 kya before a population expansion and westward migration into Central Asia and eastern/northern Europe around 8.0-10.0 kya. This northward migration of Hg N likewise coincides with retreating ice sheets after the Last Glacial Maximum (22-18 kya) in mainland East Asia.
format	article
author	Hong Shi Xuebin Qi Hua Zhong Yi Peng Xiaoming Zhang Runlin Z Ma Bing Su
author_facet	Hong Shi Xuebin Qi Hua Zhong Yi Peng Xiaoming Zhang Runlin Z Ma Bing Su
author_sort	Hong Shi
title	Genetic evidence of an East Asian origin and paleolithic northward migration of Y-chromosome haplogroup N.
title_short	Genetic evidence of an East Asian origin and paleolithic northward migration of Y-chromosome haplogroup N.
title_full	Genetic evidence of an East Asian origin and paleolithic northward migration of Y-chromosome haplogroup N.
title_fullStr	Genetic evidence of an East Asian origin and paleolithic northward migration of Y-chromosome haplogroup N.
title_full_unstemmed	Genetic evidence of an East Asian origin and paleolithic northward migration of Y-chromosome haplogroup N.
title_sort	genetic evidence of an east asian origin and paleolithic northward migration of y-chromosome haplogroup n.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/2031e9a4206147c2b6ab020c75b578e9
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Genetic evidence of an East Asian origin and paleolithic northward migration of Y-chromosome haplogroup N.

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