Alterations in the endometrium of rats, rabbits, and Macaca mulatta that received an implantation of copper/low-density polyethylene nanocomposite
Li-Xia Hu,1,* Hong Wang,1,* Meng Rao,1,* Xiao-Ling Zhao,1 Jing Yang,1 Shi-Fu Hu,1 Jing He,1,2 Wei Xia,1 Hefang Liu,1 Bo Zhen,1 Haihong Di,1 Changsheng Xie,3 Xianping Xia,3 Changhong Zhu,11Family Planning Research Institute, Tongji Medical College, Huazhong University of Science and Technology, Wuha...
Guardado en:
| Autores principales: | , , , , , , , , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Dove Medical Press
2014
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/203a36a1eff94a69b7d9650c8d861161 |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:203a36a1eff94a69b7d9650c8d861161 |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:203a36a1eff94a69b7d9650c8d8611612021-12-02T02:11:13ZAlterations in the endometrium of rats, rabbits, and Macaca mulatta that received an implantation of copper/low-density polyethylene nanocomposite1178-2013https://doaj.org/article/203a36a1eff94a69b7d9650c8d8611612014-02-01T00:00:00Zhttp://www.dovepress.com/alterations-in-the-endometrium-of-rats-rabbits-and-macaca-mulatta-that-a15956https://doaj.org/toc/1178-2013 Li-Xia Hu,1,* Hong Wang,1,* Meng Rao,1,* Xiao-Ling Zhao,1 Jing Yang,1 Shi-Fu Hu,1 Jing He,1,2 Wei Xia,1 Hefang Liu,1 Bo Zhen,1 Haihong Di,1 Changsheng Xie,3 Xianping Xia,3 Changhong Zhu,11Family Planning Research Institute, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China; 2Central Hospital of Wuhan, Wuhan, People's Republic of China; 3Department of Materials Science and Engineering, Huazhong University of Science and Technology, Wuhan, People's Republic of China *These authors contributed equally to this work Abstract: A copper/low-density polyethylene nanocomposite (nano-Cu/LDPE), a potential intrauterine device component material, has been developed from our research. A logical extension of our previous work, this study was conducted to investigate the expression of plasminogen activator inhibitor 1 (PAI-1), substance P (SP), and substance P receptor (SP-R) in the endometrium of Sprague Dawley rats, New Zealand White rabbits, and Macaca mulatta implanted with nano-Cu/LDPE composite. The influence of the nano-Cu/LDPE composite on the morphology of the endometrium was also investigated. Animals were randomly divided into five groups: the sham-operated control group (SO group), bulk copper group (Cu group), LDPE group, and nano-Cu/LDPE groups I and II. An expression of PAI-1, SP, and SP-R in the endometrial tissues was examined by immunohistochemistry at day 30, 60, 90, and 180 postimplantation. The significant difference for PAI-1, SP, and SP-R between the nano-Cu/LDPE groups and the SO group (P<0.05) was identified when the observation period was terminated, and the changes of nano-Cu/LDPE on these parameters were less remarkable than those of the Cu group (P<0.05). The damage to the endometrial morphology caused by the nano-Cu/LDPE composite was much less than that caused by bulk copper. The nano-Cu/LDPE composite might be a potential substitute for conventional materials for intrauterine devices in the future because of its decreased adverse effects on the endometrial microenvironment. Keywords: copper/low-density polyethylene nanocomposite, intrauterine device, side effects, endometriumHu LXWang HRao MZhao XLYang JHu SFHe JXia WLiu HFZhen BDi HHXie CSXia XPZhu CHDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2014, Iss Issue 1, Pp 1127-1138 (2014) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Medicine (General) R5-920 |
| spellingShingle |
Medicine (General) R5-920 Hu LX Wang H Rao M Zhao XL Yang J Hu SF He J Xia W Liu HF Zhen B Di HH Xie CS Xia XP Zhu CH Alterations in the endometrium of rats, rabbits, and Macaca mulatta that received an implantation of copper/low-density polyethylene nanocomposite |
| description |
Li-Xia Hu,1,* Hong Wang,1,* Meng Rao,1,* Xiao-Ling Zhao,1 Jing Yang,1 Shi-Fu Hu,1 Jing He,1,2 Wei Xia,1 Hefang Liu,1 Bo Zhen,1 Haihong Di,1 Changsheng Xie,3 Xianping Xia,3 Changhong Zhu,11Family Planning Research Institute, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China; 2Central Hospital of Wuhan, Wuhan, People's Republic of China; 3Department of Materials Science and Engineering, Huazhong University of Science and Technology, Wuhan, People's Republic of China *These authors contributed equally to this work Abstract: A copper/low-density polyethylene nanocomposite (nano-Cu/LDPE), a potential intrauterine device component material, has been developed from our research. A logical extension of our previous work, this study was conducted to investigate the expression of plasminogen activator inhibitor 1 (PAI-1), substance P (SP), and substance P receptor (SP-R) in the endometrium of Sprague Dawley rats, New Zealand White rabbits, and Macaca mulatta implanted with nano-Cu/LDPE composite. The influence of the nano-Cu/LDPE composite on the morphology of the endometrium was also investigated. Animals were randomly divided into five groups: the sham-operated control group (SO group), bulk copper group (Cu group), LDPE group, and nano-Cu/LDPE groups I and II. An expression of PAI-1, SP, and SP-R in the endometrial tissues was examined by immunohistochemistry at day 30, 60, 90, and 180 postimplantation. The significant difference for PAI-1, SP, and SP-R between the nano-Cu/LDPE groups and the SO group (P<0.05) was identified when the observation period was terminated, and the changes of nano-Cu/LDPE on these parameters were less remarkable than those of the Cu group (P<0.05). The damage to the endometrial morphology caused by the nano-Cu/LDPE composite was much less than that caused by bulk copper. The nano-Cu/LDPE composite might be a potential substitute for conventional materials for intrauterine devices in the future because of its decreased adverse effects on the endometrial microenvironment. Keywords: copper/low-density polyethylene nanocomposite, intrauterine device, side effects, endometrium |
| format |
article |
| author |
Hu LX Wang H Rao M Zhao XL Yang J Hu SF He J Xia W Liu HF Zhen B Di HH Xie CS Xia XP Zhu CH |
| author_facet |
Hu LX Wang H Rao M Zhao XL Yang J Hu SF He J Xia W Liu HF Zhen B Di HH Xie CS Xia XP Zhu CH |
| author_sort |
Hu LX |
| title |
Alterations in the endometrium of rats, rabbits, and Macaca mulatta that received an implantation of copper/low-density polyethylene nanocomposite |
| title_short |
Alterations in the endometrium of rats, rabbits, and Macaca mulatta that received an implantation of copper/low-density polyethylene nanocomposite |
| title_full |
Alterations in the endometrium of rats, rabbits, and Macaca mulatta that received an implantation of copper/low-density polyethylene nanocomposite |
| title_fullStr |
Alterations in the endometrium of rats, rabbits, and Macaca mulatta that received an implantation of copper/low-density polyethylene nanocomposite |
| title_full_unstemmed |
Alterations in the endometrium of rats, rabbits, and Macaca mulatta that received an implantation of copper/low-density polyethylene nanocomposite |
| title_sort |
alterations in the endometrium of rats, rabbits, and macaca mulatta that received an implantation of copper/low-density polyethylene nanocomposite |
| publisher |
Dove Medical Press |
| publishDate |
2014 |
| url |
https://doaj.org/article/203a36a1eff94a69b7d9650c8d861161 |
| work_keys_str_mv |
AT hulx alterationsintheendometriumofratsrabbitsandmacacamulattathatreceivedanimplantationofcopperlowdensitypolyethylenenanocomposite AT wangh alterationsintheendometriumofratsrabbitsandmacacamulattathatreceivedanimplantationofcopperlowdensitypolyethylenenanocomposite AT raom alterationsintheendometriumofratsrabbitsandmacacamulattathatreceivedanimplantationofcopperlowdensitypolyethylenenanocomposite AT zhaoxl alterationsintheendometriumofratsrabbitsandmacacamulattathatreceivedanimplantationofcopperlowdensitypolyethylenenanocomposite AT yangj alterationsintheendometriumofratsrabbitsandmacacamulattathatreceivedanimplantationofcopperlowdensitypolyethylenenanocomposite AT husf alterationsintheendometriumofratsrabbitsandmacacamulattathatreceivedanimplantationofcopperlowdensitypolyethylenenanocomposite AT hej alterationsintheendometriumofratsrabbitsandmacacamulattathatreceivedanimplantationofcopperlowdensitypolyethylenenanocomposite AT xiaw alterationsintheendometriumofratsrabbitsandmacacamulattathatreceivedanimplantationofcopperlowdensitypolyethylenenanocomposite AT liuhf alterationsintheendometriumofratsrabbitsandmacacamulattathatreceivedanimplantationofcopperlowdensitypolyethylenenanocomposite AT zhenb alterationsintheendometriumofratsrabbitsandmacacamulattathatreceivedanimplantationofcopperlowdensitypolyethylenenanocomposite AT dihh alterationsintheendometriumofratsrabbitsandmacacamulattathatreceivedanimplantationofcopperlowdensitypolyethylenenanocomposite AT xiecs alterationsintheendometriumofratsrabbitsandmacacamulattathatreceivedanimplantationofcopperlowdensitypolyethylenenanocomposite AT xiaxp alterationsintheendometriumofratsrabbitsandmacacamulattathatreceivedanimplantationofcopperlowdensitypolyethylenenanocomposite AT zhuch alterationsintheendometriumofratsrabbitsandmacacamulattathatreceivedanimplantationofcopperlowdensitypolyethylenenanocomposite |
| _version_ |
1718402636583010304 |