Burden of chronic kidney disease in the general population and high-risk groups in South Asia: A systematic review and meta-analysis.

<h4>Background</h4>Chronic kidney disease (CKD) is an emerging public health issue globally. The prevalence estimates on CKD in South Asia are however limited. This study aimed to examine the prevalence of CKD among the general and high-risk population in South Asia.<h4>Methods<...

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Autores principales:	Nipun Shrestha, Sanju Gautam, Shiva Raj Mishra, Salim S Virani, Raja Ram Dhungana
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/203e4aeba5284312b688ba92089fea41
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spelling	oai:doaj.org-article:203e4aeba5284312b688ba92089fea412021-12-02T20:19:12ZBurden of chronic kidney disease in the general population and high-risk groups in South Asia: A systematic review and meta-analysis.1932-620310.1371/journal.pone.0258494https://doaj.org/article/203e4aeba5284312b688ba92089fea412021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0258494https://doaj.org/toc/1932-6203<h4>Background</h4>Chronic kidney disease (CKD) is an emerging public health issue globally. The prevalence estimates on CKD in South Asia are however limited. This study aimed to examine the prevalence of CKD among the general and high-risk population in South Asia.<h4>Methods</h4>We conducted a systematic review and meta-analysis of population-level prevalence studies in South Asia (Afghanistan, Bangladesh, Bhutan, Maldives, Nepal, India, Pakistan, and Sri Lanka). Three databases namely PubMed, Scopus and Web of Science were systematically searched for published reports of kidney disease in South Asia up to 28 October 2020. A random-effect model for computing the pooled prevalence was used.<h4>Results</h4>Of the 8749 identified studies, a total of 24 studies were included in the review. The pooled prevalence of CKD among the general population was 14% (95% CI 11-18%), and 15% (95% CI 11-20%) among adult males and 13% (95% CI 10-17%) in adult females. The prevalence of CKD was 27% (95% CI 20-35%) in adults with hypertension, 31% (95% CI 22-41%) in adults with diabetes and 14% (95% CI 10-19%) in adults who were overweight/obese. We found substantial heterogeneity across the included studies in the pooled estimates for CKD prevalence in both general and high-risk populations. The prevalence of CKD of unknown origin in the endemic population was 8% (95% CI 3-16%).<h4>Conclusion</h4>Our study reaffirms the previous reports that CKD represents a serious public health challenge in South Asia, with the disease prevalent among 1 in 7 adults in South Asian countries.Nipun ShresthaSanju GautamShiva Raj MishraSalim S ViraniRaja Ram DhunganaPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 10, p e0258494 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Nipun Shrestha Sanju Gautam Shiva Raj Mishra Salim S Virani Raja Ram Dhungana Burden of chronic kidney disease in the general population and high-risk groups in South Asia: A systematic review and meta-analysis.
description	<h4>Background</h4>Chronic kidney disease (CKD) is an emerging public health issue globally. The prevalence estimates on CKD in South Asia are however limited. This study aimed to examine the prevalence of CKD among the general and high-risk population in South Asia.<h4>Methods</h4>We conducted a systematic review and meta-analysis of population-level prevalence studies in South Asia (Afghanistan, Bangladesh, Bhutan, Maldives, Nepal, India, Pakistan, and Sri Lanka). Three databases namely PubMed, Scopus and Web of Science were systematically searched for published reports of kidney disease in South Asia up to 28 October 2020. A random-effect model for computing the pooled prevalence was used.<h4>Results</h4>Of the 8749 identified studies, a total of 24 studies were included in the review. The pooled prevalence of CKD among the general population was 14% (95% CI 11-18%), and 15% (95% CI 11-20%) among adult males and 13% (95% CI 10-17%) in adult females. The prevalence of CKD was 27% (95% CI 20-35%) in adults with hypertension, 31% (95% CI 22-41%) in adults with diabetes and 14% (95% CI 10-19%) in adults who were overweight/obese. We found substantial heterogeneity across the included studies in the pooled estimates for CKD prevalence in both general and high-risk populations. The prevalence of CKD of unknown origin in the endemic population was 8% (95% CI 3-16%).<h4>Conclusion</h4>Our study reaffirms the previous reports that CKD represents a serious public health challenge in South Asia, with the disease prevalent among 1 in 7 adults in South Asian countries.
format	article
author	Nipun Shrestha Sanju Gautam Shiva Raj Mishra Salim S Virani Raja Ram Dhungana
author_facet	Nipun Shrestha Sanju Gautam Shiva Raj Mishra Salim S Virani Raja Ram Dhungana
author_sort	Nipun Shrestha
title	Burden of chronic kidney disease in the general population and high-risk groups in South Asia: A systematic review and meta-analysis.
title_short	Burden of chronic kidney disease in the general population and high-risk groups in South Asia: A systematic review and meta-analysis.
title_full	Burden of chronic kidney disease in the general population and high-risk groups in South Asia: A systematic review and meta-analysis.
title_fullStr	Burden of chronic kidney disease in the general population and high-risk groups in South Asia: A systematic review and meta-analysis.
title_full_unstemmed	Burden of chronic kidney disease in the general population and high-risk groups in South Asia: A systematic review and meta-analysis.
title_sort	burden of chronic kidney disease in the general population and high-risk groups in south asia: a systematic review and meta-analysis.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/203e4aeba5284312b688ba92089fea41
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Burden of chronic kidney disease in the general population and high-risk groups in South Asia: A systematic review and meta-analysis.

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