Osteonecrosis as the presenting feature in a child with acute lymphoblastic leukaemia

A seven-year-old girl presented with pain in multiple joints and constitutional symptoms over a period of four months. There were no significant clinical findings apart from joint tenderness. Blood test results did not indicate any specific pathology and initial radiology imaging was normal. Subsequ...

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Auteurs principaux:	Lim Sern Chin, Bushra Johari, Tang Swee Ping
Format:	article
Langue:	EN
Publié:	Academy of Family Physicians of Malaysia 2021
Sujets:	osteonecrosis acute lymphoblastic leukaemia joint pain Medicine R
Accès en ligne:	https://doaj.org/article/203e81e2d738421a9b7a19325e86a9b8
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id	oai:doaj.org-article:203e81e2d738421a9b7a19325e86a9b8
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spelling	oai:doaj.org-article:203e81e2d738421a9b7a19325e86a9b82021-12-04T08:31:12ZOsteonecrosis as the presenting feature in a child with acute lymphoblastic leukaemia10.51866/cr11761985-2274https://doaj.org/article/203e81e2d738421a9b7a19325e86a9b82021-09-01T00:00:00Zhttps://e-mfp.org/wp-content/uploads/v16n3-Cr-Osteonecrosis-as-the-presenting.pdfhttps://doaj.org/toc/1985-2274A seven-year-old girl presented with pain in multiple joints and constitutional symptoms over a period of four months. There were no significant clinical findings apart from joint tenderness. Blood test results did not indicate any specific pathology and initial radiology imaging was normal. Subsequent careful examination of her X-ray images led to an MRI of her left knee, which revealed acute osteonecrotic changes. A following whole-body MRI examination demonstrated multifocal bony lesions. Bone marrow examination conclusively diagnosed acute lymphoblastic leukaemia (ALL). Acute osteonecrosis has classically been described as a complication of treatment in children with ALL and has not been recognised as a presenting feature until recently.Lim Sern ChinBushra JohariTang Swee PingAcademy of Family Physicians of Malaysiaarticleosteonecrosisacute lymphoblastic leukaemiajoint painMedicineRENMalaysian Family Physician, Vol 16, Iss 3, Pp 115-118 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	osteonecrosis acute lymphoblastic leukaemia joint pain Medicine R
spellingShingle	osteonecrosis acute lymphoblastic leukaemia joint pain Medicine R Lim Sern Chin Bushra Johari Tang Swee Ping Osteonecrosis as the presenting feature in a child with acute lymphoblastic leukaemia
description	A seven-year-old girl presented with pain in multiple joints and constitutional symptoms over a period of four months. There were no significant clinical findings apart from joint tenderness. Blood test results did not indicate any specific pathology and initial radiology imaging was normal. Subsequent careful examination of her X-ray images led to an MRI of her left knee, which revealed acute osteonecrotic changes. A following whole-body MRI examination demonstrated multifocal bony lesions. Bone marrow examination conclusively diagnosed acute lymphoblastic leukaemia (ALL). Acute osteonecrosis has classically been described as a complication of treatment in children with ALL and has not been recognised as a presenting feature until recently.
format	article
author	Lim Sern Chin Bushra Johari Tang Swee Ping
author_facet	Lim Sern Chin Bushra Johari Tang Swee Ping
author_sort	Lim Sern Chin
title	Osteonecrosis as the presenting feature in a child with acute lymphoblastic leukaemia
title_short	Osteonecrosis as the presenting feature in a child with acute lymphoblastic leukaemia
title_full	Osteonecrosis as the presenting feature in a child with acute lymphoblastic leukaemia
title_fullStr	Osteonecrosis as the presenting feature in a child with acute lymphoblastic leukaemia
title_full_unstemmed	Osteonecrosis as the presenting feature in a child with acute lymphoblastic leukaemia
title_sort	osteonecrosis as the presenting feature in a child with acute lymphoblastic leukaemia
publisher	Academy of Family Physicians of Malaysia
publishDate	2021
url	https://doaj.org/article/203e81e2d738421a9b7a19325e86a9b8
work_keys_str_mv	AT limsernchin osteonecrosisasthepresentingfeatureinachildwithacutelymphoblasticleukaemia AT bushrajohari osteonecrosisasthepresentingfeatureinachildwithacutelymphoblasticleukaemia AT tangsweeping osteonecrosisasthepresentingfeatureinachildwithacutelymphoblasticleukaemia
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Osteonecrosis as the presenting feature in a child with acute lymphoblastic leukaemia

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