Immune responses against Helicobacter pylori-specific antigens differentiate relapsing remitting from secondary progressive multiple sclerosis

Abstract To assess whether Helicobacter pylori (Hp) antibody (ab) reactivity against individual Hp antigens is pathogenetically relevant to multiple sclerosis (MS), we systematically investigated prevalence and clinical significance of abs against 14 immunodominant and subdominant Hp antigens by ELI...

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Autores principales:	Georgios Efthymiou, Efthymios Dardiotis, Christos Liaskos, Emmanouela Marou, Vana Tsimourtou, Eirini I. Rigopoulou, Thomas Scheper, Alexandros Daponte, Wolfgang Meyer, Lazaros I. Sakkas, Georgios Hadjigeorgiou, Dimitrios P. Bogdanos
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/20412d73299e42d7b8db0e7fb1078244
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spelling	oai:doaj.org-article:20412d73299e42d7b8db0e7fb10782442021-12-02T15:05:44ZImmune responses against Helicobacter pylori-specific antigens differentiate relapsing remitting from secondary progressive multiple sclerosis10.1038/s41598-017-07801-92045-2322https://doaj.org/article/20412d73299e42d7b8db0e7fb10782442017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-07801-9https://doaj.org/toc/2045-2322Abstract To assess whether Helicobacter pylori (Hp) antibody (ab) reactivity against individual Hp antigens is pathogenetically relevant to multiple sclerosis (MS), we systematically investigated prevalence and clinical significance of abs against 14 immunodominant and subdominant Hp antigens by ELISA and immunoblotting in 139 consecutive MS patients with relapsing-remitting (RRMS, n = 102) or secondary progressive (SPMS, n = 37). Sera from 39 patients with Parkinson’s disease (PD), 21 with Alzheimer’s disease (ALZ) and 68 healthy controls (HCs), were also tested. Anti-flagellin (18.3%) and anti-p41 (25.0%) abs in MS were less frequent than in HCs (39.4%, 48.5%, respectively). Abs against 5 of the 14 antigens were less frequent in RRMS than HCs, including p41, p54-flagellin, p29-UreA, p67-FSH, and p120-CagA. Anti-VacA abs were more frequent in SPMS than in HCs (42.1 vs 12.1%, p = 0.019). Anti-p54, anti-p29-UreA and anti-p26 correlated with extended disability status scale (EDSS) (p = 0.017, p = 0.005, p = 0.002, respectively). Anti-p26 and anti-p17 correlated with the number of relapses (p = 0.037 and p = 0.047, respectively). This is the first comprehensive analysis of ab reactivities against most Hp antigens in MS patients. Ab responses differ between MS and HCs and between RRMS and SPMS, being more prevalent in SPMS than RRMS, thus suggesting an association between anti-Hp and the former type of MS.Georgios EfthymiouEfthymios DardiotisChristos LiaskosEmmanouela MarouVana TsimourtouEirini I. RigopoulouThomas ScheperAlexandros DaponteWolfgang MeyerLazaros I. SakkasGeorgios HadjigeorgiouDimitrios P. BogdanosNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Georgios Efthymiou Efthymios Dardiotis Christos Liaskos Emmanouela Marou Vana Tsimourtou Eirini I. Rigopoulou Thomas Scheper Alexandros Daponte Wolfgang Meyer Lazaros I. Sakkas Georgios Hadjigeorgiou Dimitrios P. Bogdanos Immune responses against Helicobacter pylori-specific antigens differentiate relapsing remitting from secondary progressive multiple sclerosis
description	Abstract To assess whether Helicobacter pylori (Hp) antibody (ab) reactivity against individual Hp antigens is pathogenetically relevant to multiple sclerosis (MS), we systematically investigated prevalence and clinical significance of abs against 14 immunodominant and subdominant Hp antigens by ELISA and immunoblotting in 139 consecutive MS patients with relapsing-remitting (RRMS, n = 102) or secondary progressive (SPMS, n = 37). Sera from 39 patients with Parkinson’s disease (PD), 21 with Alzheimer’s disease (ALZ) and 68 healthy controls (HCs), were also tested. Anti-flagellin (18.3%) and anti-p41 (25.0%) abs in MS were less frequent than in HCs (39.4%, 48.5%, respectively). Abs against 5 of the 14 antigens were less frequent in RRMS than HCs, including p41, p54-flagellin, p29-UreA, p67-FSH, and p120-CagA. Anti-VacA abs were more frequent in SPMS than in HCs (42.1 vs 12.1%, p = 0.019). Anti-p54, anti-p29-UreA and anti-p26 correlated with extended disability status scale (EDSS) (p = 0.017, p = 0.005, p = 0.002, respectively). Anti-p26 and anti-p17 correlated with the number of relapses (p = 0.037 and p = 0.047, respectively). This is the first comprehensive analysis of ab reactivities against most Hp antigens in MS patients. Ab responses differ between MS and HCs and between RRMS and SPMS, being more prevalent in SPMS than RRMS, thus suggesting an association between anti-Hp and the former type of MS.
format	article
author	Georgios Efthymiou Efthymios Dardiotis Christos Liaskos Emmanouela Marou Vana Tsimourtou Eirini I. Rigopoulou Thomas Scheper Alexandros Daponte Wolfgang Meyer Lazaros I. Sakkas Georgios Hadjigeorgiou Dimitrios P. Bogdanos
author_facet	Georgios Efthymiou Efthymios Dardiotis Christos Liaskos Emmanouela Marou Vana Tsimourtou Eirini I. Rigopoulou Thomas Scheper Alexandros Daponte Wolfgang Meyer Lazaros I. Sakkas Georgios Hadjigeorgiou Dimitrios P. Bogdanos
author_sort	Georgios Efthymiou
title	Immune responses against Helicobacter pylori-specific antigens differentiate relapsing remitting from secondary progressive multiple sclerosis
title_short	Immune responses against Helicobacter pylori-specific antigens differentiate relapsing remitting from secondary progressive multiple sclerosis
title_full	Immune responses against Helicobacter pylori-specific antigens differentiate relapsing remitting from secondary progressive multiple sclerosis
title_fullStr	Immune responses against Helicobacter pylori-specific antigens differentiate relapsing remitting from secondary progressive multiple sclerosis
title_full_unstemmed	Immune responses against Helicobacter pylori-specific antigens differentiate relapsing remitting from secondary progressive multiple sclerosis
title_sort	immune responses against helicobacter pylori-specific antigens differentiate relapsing remitting from secondary progressive multiple sclerosis
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/20412d73299e42d7b8db0e7fb1078244
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Immune responses against Helicobacter pylori-specific antigens differentiate relapsing remitting from secondary progressive multiple sclerosis

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