Single laser pulse generates dual photoacoustic signals for differential contrast photoacoustic imaging

Abstract Photoacoustic sensing and imaging techniques have been studied widely to explore optical absorption contrast based on nanosecond laser illumination. In this paper, we report a long laser pulse induced dual photoacoustic (LDPA) nonlinear effect, which originates from unsatisfied stress and t...

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Autores principales:	Fei Gao, Xiaohua Feng, Ruochong Zhang, Siyu Liu, Ran Ding, Rahul Kishor, Yuanjin Zheng
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/204227ad6fe94801ba2ea1cf52ddcdd9
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spelling	oai:doaj.org-article:204227ad6fe94801ba2ea1cf52ddcdd92021-12-02T11:52:15ZSingle laser pulse generates dual photoacoustic signals for differential contrast photoacoustic imaging10.1038/s41598-017-00725-42045-2322https://doaj.org/article/204227ad6fe94801ba2ea1cf52ddcdd92017-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-00725-4https://doaj.org/toc/2045-2322Abstract Photoacoustic sensing and imaging techniques have been studied widely to explore optical absorption contrast based on nanosecond laser illumination. In this paper, we report a long laser pulse induced dual photoacoustic (LDPA) nonlinear effect, which originates from unsatisfied stress and thermal confinements. Being different from conventional short laser pulse illumination, the proposed method utilizes a long square-profile laser pulse to induce dual photoacoustic signals. Without satisfying the stress confinement, the dual photoacoustic signals are generated following the positive and negative edges of the long laser pulse. More interestingly, the first expansion-induced photoacoustic signal exhibits positive waveform due to the initial sharp rising of temperature. On the contrary, the second contraction-induced photoacoustic signal exhibits exactly negative waveform due to the falling of temperature, as well as pulse-width-dependent signal amplitude. An analytical model is derived to describe the generation of the dual photoacoustic pulses, incorporating Gruneisen saturation and thermal diffusion effect, which is experimentally proved. Lastly, an alternate of LDPA technique using quasi-CW laser excitation is also introduced and demonstrated for both super-contrast in vitro and in vivo imaging. Compared with existing nonlinear PA techniques, the proposed LDPA nonlinear effect could enable a much broader range of potential applications.Fei GaoXiaohua FengRuochong ZhangSiyu LiuRan DingRahul KishorYuanjin ZhengNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Fei Gao Xiaohua Feng Ruochong Zhang Siyu Liu Ran Ding Rahul Kishor Yuanjin Zheng Single laser pulse generates dual photoacoustic signals for differential contrast photoacoustic imaging
description	Abstract Photoacoustic sensing and imaging techniques have been studied widely to explore optical absorption contrast based on nanosecond laser illumination. In this paper, we report a long laser pulse induced dual photoacoustic (LDPA) nonlinear effect, which originates from unsatisfied stress and thermal confinements. Being different from conventional short laser pulse illumination, the proposed method utilizes a long square-profile laser pulse to induce dual photoacoustic signals. Without satisfying the stress confinement, the dual photoacoustic signals are generated following the positive and negative edges of the long laser pulse. More interestingly, the first expansion-induced photoacoustic signal exhibits positive waveform due to the initial sharp rising of temperature. On the contrary, the second contraction-induced photoacoustic signal exhibits exactly negative waveform due to the falling of temperature, as well as pulse-width-dependent signal amplitude. An analytical model is derived to describe the generation of the dual photoacoustic pulses, incorporating Gruneisen saturation and thermal diffusion effect, which is experimentally proved. Lastly, an alternate of LDPA technique using quasi-CW laser excitation is also introduced and demonstrated for both super-contrast in vitro and in vivo imaging. Compared with existing nonlinear PA techniques, the proposed LDPA nonlinear effect could enable a much broader range of potential applications.
format	article
author	Fei Gao Xiaohua Feng Ruochong Zhang Siyu Liu Ran Ding Rahul Kishor Yuanjin Zheng
author_facet	Fei Gao Xiaohua Feng Ruochong Zhang Siyu Liu Ran Ding Rahul Kishor Yuanjin Zheng
author_sort	Fei Gao
title	Single laser pulse generates dual photoacoustic signals for differential contrast photoacoustic imaging
title_short	Single laser pulse generates dual photoacoustic signals for differential contrast photoacoustic imaging
title_full	Single laser pulse generates dual photoacoustic signals for differential contrast photoacoustic imaging
title_fullStr	Single laser pulse generates dual photoacoustic signals for differential contrast photoacoustic imaging
title_full_unstemmed	Single laser pulse generates dual photoacoustic signals for differential contrast photoacoustic imaging
title_sort	single laser pulse generates dual photoacoustic signals for differential contrast photoacoustic imaging
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/204227ad6fe94801ba2ea1cf52ddcdd9
work_keys_str_mv	AT feigao singlelaserpulsegeneratesdualphotoacousticsignalsfordifferentialcontrastphotoacousticimaging AT xiaohuafeng singlelaserpulsegeneratesdualphotoacousticsignalsfordifferentialcontrastphotoacousticimaging AT ruochongzhang singlelaserpulsegeneratesdualphotoacousticsignalsfordifferentialcontrastphotoacousticimaging AT siyuliu singlelaserpulsegeneratesdualphotoacousticsignalsfordifferentialcontrastphotoacousticimaging AT randing singlelaserpulsegeneratesdualphotoacousticsignalsfordifferentialcontrastphotoacousticimaging AT rahulkishor singlelaserpulsegeneratesdualphotoacousticsignalsfordifferentialcontrastphotoacousticimaging AT yuanjinzheng singlelaserpulsegeneratesdualphotoacousticsignalsfordifferentialcontrastphotoacousticimaging
_version_	1718395090916868096

Single laser pulse generates dual photoacoustic signals for differential contrast photoacoustic imaging

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