The Importance of Erythrocyte Arginase Activity In Acute Myocardial

Arginase (L-Arginine amidinohydrolase; EC 3.5.3.1), the final enzyme in theurea cycle, is responsible for the detoxification of ammonia in the liver of themammalian. In extrahepatic mammalian tissues, arginase is believed to supply thecell with ornithine, a crucial metabolite in biosynthesis of glut...

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Autores principales:	Şendoğan Gülen, Zihni Aktaş, Fatih Özçelik, Selma Süer Gökmen, Reyhan Yıldız
Formato:	article
Lenguaje:	EN
Publicado:	De Gruyter 2006
Materias:	Arginase aspartate aminotransferase lactate dehydrogenase creatine kinase-MB acute myocardial infarction Biochemistry QD415-436
Acceso en línea:	https://doaj.org/article/204809f514624c04ae28abc0cf1dea49
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spelling	oai:doaj.org-article:204809f514624c04ae28abc0cf1dea492021-12-02T11:45:21ZThe Importance of Erythrocyte Arginase Activity In Acute Myocardial0250-46851303-829Xhttps://doaj.org/article/204809f514624c04ae28abc0cf1dea492006-09-01T00:00:00Zhttp://www.turkjbiochem.com/2006/115.pdfhttps://doaj.org/toc/0250-4685https://doaj.org/toc/1303-829XArginase (L-Arginine amidinohydrolase; EC 3.5.3.1), the final enzyme in theurea cycle, is responsible for the detoxification of ammonia in the liver of themammalian. In extrahepatic mammalian tissues, arginase is believed to supply thecell with ornithine, a crucial metabolite in biosynthesis of glutamic acid, proline andpolyamines. The purpose of the present study is to investigate whether erythrocytearginase activity is changed in patients with acute myocardial infarction at 24 hour,48 hour and on day 10 post-infarction together with aspartate aminotransferase(AST), lactate dehydrogenase (LDH) and creatine kinase-MB (CK-MB), themarkers of myocardial cell damage. In this study, 49 subjects with acute myocardialinfarction and 35 healthy volunteers were included. Erythrocyte arginase activitydetermination was carried out by the methods of Geyer and Dabich. Serum AST,LDH and CK-MB activities were measured with an automatic biochemistryanalyzer by commercial kits. Our results showed that both arginase and cardiacmarker enzyme activities are elevated at 24 hour post-infarction, and then they aredecreased at 48 hour post-infarction as compared to those at the first day whilethey are still elevated when compared with control group and except LDH, allenzyme activities are returned to control levels on day 10 post-infarction in patientswith acute myocardial infarction. We think that the observation of the changes inerythrocyte arginase activity at 24 hour, 48 hour and on day 10 post-infarction maybe useful for diagnosis of acute myocardial infarction.Şendoğan GülenZihni AktaşFatih ÖzçelikSelma Süer Gökmen,Reyhan Yıldız,De GruyterarticleArginaseaspartate aminotransferaselactate dehydrogenasecreatine kinase-MBacute myocardial infarctionBiochemistryQD415-436ENTürk Biyokimya Dergisi, Vol 31, Iss 3, Pp 115-123 (2006)
institution	DOAJ
collection	DOAJ
language	EN
topic	Arginase aspartate aminotransferase lactate dehydrogenase creatine kinase-MB acute myocardial infarction Biochemistry QD415-436
spellingShingle	Arginase aspartate aminotransferase lactate dehydrogenase creatine kinase-MB acute myocardial infarction Biochemistry QD415-436 Şendoğan Gülen Zihni Aktaş Fatih Özçelik Selma Süer Gökmen, Reyhan Yıldız, The Importance of Erythrocyte Arginase Activity In Acute Myocardial
description	Arginase (L-Arginine amidinohydrolase; EC 3.5.3.1), the final enzyme in theurea cycle, is responsible for the detoxification of ammonia in the liver of themammalian. In extrahepatic mammalian tissues, arginase is believed to supply thecell with ornithine, a crucial metabolite in biosynthesis of glutamic acid, proline andpolyamines. The purpose of the present study is to investigate whether erythrocytearginase activity is changed in patients with acute myocardial infarction at 24 hour,48 hour and on day 10 post-infarction together with aspartate aminotransferase(AST), lactate dehydrogenase (LDH) and creatine kinase-MB (CK-MB), themarkers of myocardial cell damage. In this study, 49 subjects with acute myocardialinfarction and 35 healthy volunteers were included. Erythrocyte arginase activitydetermination was carried out by the methods of Geyer and Dabich. Serum AST,LDH and CK-MB activities were measured with an automatic biochemistryanalyzer by commercial kits. Our results showed that both arginase and cardiacmarker enzyme activities are elevated at 24 hour post-infarction, and then they aredecreased at 48 hour post-infarction as compared to those at the first day whilethey are still elevated when compared with control group and except LDH, allenzyme activities are returned to control levels on day 10 post-infarction in patientswith acute myocardial infarction. We think that the observation of the changes inerythrocyte arginase activity at 24 hour, 48 hour and on day 10 post-infarction maybe useful for diagnosis of acute myocardial infarction.
format	article
author	Şendoğan Gülen Zihni Aktaş Fatih Özçelik Selma Süer Gökmen, Reyhan Yıldız,
author_facet	Şendoğan Gülen Zihni Aktaş Fatih Özçelik Selma Süer Gökmen, Reyhan Yıldız,
author_sort	Şendoğan Gülen
title	The Importance of Erythrocyte Arginase Activity In Acute Myocardial
title_short	The Importance of Erythrocyte Arginase Activity In Acute Myocardial
title_full	The Importance of Erythrocyte Arginase Activity In Acute Myocardial
title_fullStr	The Importance of Erythrocyte Arginase Activity In Acute Myocardial
title_full_unstemmed	The Importance of Erythrocyte Arginase Activity In Acute Myocardial
title_sort	importance of erythrocyte arginase activity in acute myocardial
publisher	De Gruyter
publishDate	2006
url	https://doaj.org/article/204809f514624c04ae28abc0cf1dea49
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The Importance of Erythrocyte Arginase Activity In Acute Myocardial

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