A multiplexed, automated evolution pipeline enables scalable discovery and characterization of biosensors

Biosensors are key to engineered biological systems. Here the authors demonstrate rapid de novo in vitro evolution of RNA biosensors of small molecules in a fully automated system.

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Detalles Bibliográficos
Autores principales: Brent Townshend, Joy S. Xiang, Gabriel Manzanarez, Eric J. Hayden, Christina D. Smolke
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
Materias:
Q
Acceso en línea:https://doaj.org/article/2049eb336bef4898b46560e95fa9af7a
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Descripción
Sumario:Biosensors are key to engineered biological systems. Here the authors demonstrate rapid de novo in vitro evolution of RNA biosensors of small molecules in a fully automated system.