A multiplexed, automated evolution pipeline enables scalable discovery and characterization of biosensors

Biosensors are key to engineered biological systems. Here the authors demonstrate rapid de novo in vitro evolution of RNA biosensors of small molecules in a fully automated system.

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Autores principales:	Brent Townshend, Joy S. Xiang, Gabriel Manzanarez, Eric J. Hayden, Christina D. Smolke
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/2049eb336bef4898b46560e95fa9af7a
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spelling	oai:doaj.org-article:2049eb336bef4898b46560e95fa9af7a2021-12-02T13:15:06ZA multiplexed, automated evolution pipeline enables scalable discovery and characterization of biosensors10.1038/s41467-021-21716-02041-1723https://doaj.org/article/2049eb336bef4898b46560e95fa9af7a2021-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21716-0https://doaj.org/toc/2041-1723Biosensors are key to engineered biological systems. Here the authors demonstrate rapid de novo in vitro evolution of RNA biosensors of small molecules in a fully automated system.Brent TownshendJoy S. XiangGabriel ManzanarezEric J. HaydenChristina D. SmolkeNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Brent Townshend Joy S. Xiang Gabriel Manzanarez Eric J. Hayden Christina D. Smolke A multiplexed, automated evolution pipeline enables scalable discovery and characterization of biosensors
description	Biosensors are key to engineered biological systems. Here the authors demonstrate rapid de novo in vitro evolution of RNA biosensors of small molecules in a fully automated system.
format	article
author	Brent Townshend Joy S. Xiang Gabriel Manzanarez Eric J. Hayden Christina D. Smolke
author_facet	Brent Townshend Joy S. Xiang Gabriel Manzanarez Eric J. Hayden Christina D. Smolke
author_sort	Brent Townshend
title	A multiplexed, automated evolution pipeline enables scalable discovery and characterization of biosensors
title_short	A multiplexed, automated evolution pipeline enables scalable discovery and characterization of biosensors
title_full	A multiplexed, automated evolution pipeline enables scalable discovery and characterization of biosensors
title_fullStr	A multiplexed, automated evolution pipeline enables scalable discovery and characterization of biosensors
title_full_unstemmed	A multiplexed, automated evolution pipeline enables scalable discovery and characterization of biosensors
title_sort	multiplexed, automated evolution pipeline enables scalable discovery and characterization of biosensors
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/2049eb336bef4898b46560e95fa9af7a
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A multiplexed, automated evolution pipeline enables scalable discovery and characterization of biosensors

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