$Asymptomatic morphometric vertebral fractures and its associated factors: A cross-sectional study among adults in a selected urban area in Selangor, Malaysia.$
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Asymptomatic morphometric vertebral fractures and its associated factors: A cross-sectional study among adults in a selected urban area in Selangor, Malaysia.

<h4>Objective</h4>This study aimed to determine the prevalence of vertebral fractures (VF) in a selected urban population in Malaysia and to explore possible variables associated with VF in the study population.<h4>Methods</h4>A cross-sectional study involving community-livin...

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Autores principales:	Swan Sim Yeap, Subashini C Thambiah, Subapriya Suppiah, Salmiah Md-Said, Geeta Appannah, Intan Nureslyna Samsudin, Nurunnaim Zainuddin, Siti Yazmin Zahari-Sham, Fen Lee Hew
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/204db8c1528d474daa5c1b105c3fb53f
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spelling	oai:doaj.org-article:204db8c1528d474daa5c1b105c3fb53f2021-12-02T20:06:33ZAsymptomatic morphometric vertebral fractures and its associated factors: A cross-sectional study among adults in a selected urban area in Selangor, Malaysia.1932-620310.1371/journal.pone.0255069https://doaj.org/article/204db8c1528d474daa5c1b105c3fb53f2021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0255069https://doaj.org/toc/1932-6203<h4>Objective</h4>This study aimed to determine the prevalence of vertebral fractures (VF) in a selected urban population in Malaysia and to explore possible variables associated with VF in the study population.<h4>Methods</h4>A cross-sectional study involving community-living, healthy subjects aged between 45-90 years from the state of Selangor, Malaysia, were invited to attend a bone health check-up. Subjects with diseases known to affect bone metabolism or were on treatment for osteoporosis (OP) were excluded. Bone mineral density (BMD) was measured using dual energy X-ray absorptiometry (DXA). Lateral and antero-posterior view lumbar spine x-rays were performed and VF was determined by the semi-quantitative Genant method.<h4>Results</h4>A total of 386 subjects were studied. Asymptomatic morphometric VF were found in 44 (11.4%) subjects. T12 was the most common vertebrae to be fractured. The prevalence of VF was significantly higher in menopausal women (12.4%) compared to non-menopausal women, in those above the age of 60 (18.5%), in those of Chinese ethnicity (16.5%), in those with a low body fat percentage (17.1%) and among those with OP (27.0%). The mean (standard deviation) 25-hydroxyvitamin D [25(OH)D] levels were significantly higher in those with VF compared to those without VF, 67.64 (23.50) and 57.47 (21.71) nmol/L, respectively. However, after multiple regression analysis, age over 60 years and OP on DXA BMD measurement were the only significant associated factors for VF.<h4>Conclusion</h4>Overall, 11.4% of a selected Malaysian urban population had asymptomatic morphometric VF. Age over 60 years and OP on DXA BMD measurement, but not 25(OH)D levels, were associated with VF.Swan Sim YeapSubashini C ThambiahSubapriya SuppiahSalmiah Md-SaidGeeta AppannahIntan Nureslyna SamsudinNurunnaim ZainuddinSiti Yazmin Zahari-ShamFen Lee HewPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 7, p e0255069 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Swan Sim Yeap Subashini C Thambiah Subapriya Suppiah Salmiah Md-Said Geeta Appannah Intan Nureslyna Samsudin Nurunnaim Zainuddin Siti Yazmin Zahari-Sham Fen Lee Hew Asymptomatic morphometric vertebral fractures and its associated factors: A cross-sectional study among adults in a selected urban area in Selangor, Malaysia.
description	<h4>Objective</h4>This study aimed to determine the prevalence of vertebral fractures (VF) in a selected urban population in Malaysia and to explore possible variables associated with VF in the study population.<h4>Methods</h4>A cross-sectional study involving community-living, healthy subjects aged between 45-90 years from the state of Selangor, Malaysia, were invited to attend a bone health check-up. Subjects with diseases known to affect bone metabolism or were on treatment for osteoporosis (OP) were excluded. Bone mineral density (BMD) was measured using dual energy X-ray absorptiometry (DXA). Lateral and antero-posterior view lumbar spine x-rays were performed and VF was determined by the semi-quantitative Genant method.<h4>Results</h4>A total of 386 subjects were studied. Asymptomatic morphometric VF were found in 44 (11.4%) subjects. T12 was the most common vertebrae to be fractured. The prevalence of VF was significantly higher in menopausal women (12.4%) compared to non-menopausal women, in those above the age of 60 (18.5%), in those of Chinese ethnicity (16.5%), in those with a low body fat percentage (17.1%) and among those with OP (27.0%). The mean (standard deviation) 25-hydroxyvitamin D [25(OH)D] levels were significantly higher in those with VF compared to those without VF, 67.64 (23.50) and 57.47 (21.71) nmol/L, respectively. However, after multiple regression analysis, age over 60 years and OP on DXA BMD measurement were the only significant associated factors for VF.<h4>Conclusion</h4>Overall, 11.4% of a selected Malaysian urban population had asymptomatic morphometric VF. Age over 60 years and OP on DXA BMD measurement, but not 25(OH)D levels, were associated with VF.
format	article
author	Swan Sim Yeap Subashini C Thambiah Subapriya Suppiah Salmiah Md-Said Geeta Appannah Intan Nureslyna Samsudin Nurunnaim Zainuddin Siti Yazmin Zahari-Sham Fen Lee Hew
author_facet	Swan Sim Yeap Subashini C Thambiah Subapriya Suppiah Salmiah Md-Said Geeta Appannah Intan Nureslyna Samsudin Nurunnaim Zainuddin Siti Yazmin Zahari-Sham Fen Lee Hew
author_sort	Swan Sim Yeap
title	Asymptomatic morphometric vertebral fractures and its associated factors: A cross-sectional study among adults in a selected urban area in Selangor, Malaysia.
title_short	Asymptomatic morphometric vertebral fractures and its associated factors: A cross-sectional study among adults in a selected urban area in Selangor, Malaysia.
title_full	Asymptomatic morphometric vertebral fractures and its associated factors: A cross-sectional study among adults in a selected urban area in Selangor, Malaysia.
title_fullStr	Asymptomatic morphometric vertebral fractures and its associated factors: A cross-sectional study among adults in a selected urban area in Selangor, Malaysia.
title_full_unstemmed	Asymptomatic morphometric vertebral fractures and its associated factors: A cross-sectional study among adults in a selected urban area in Selangor, Malaysia.
title_sort	asymptomatic morphometric vertebral fractures and its associated factors: a cross-sectional study among adults in a selected urban area in selangor, malaysia.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/204db8c1528d474daa5c1b105c3fb53f
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Asymptomatic morphometric vertebral fractures and its associated factors: A cross-sectional study among adults in a selected urban area in Selangor, Malaysia.

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