Double-edged effects of interferons on the regulation of cancer-immunity cycle

Interferons (IFNs) are a large family of pleiotropic cytokines that regulate both innate and adaptive immunity and show anti-cancer effects in various cancer types. Moreover, it was revealed that IFN signaling plays critical roles in the success of cancer therapy strategies, thereby enhancing their...

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Autores principales:	Xiao Zhang, Song Wang, Yuanyuan Zhu, Minghui Zhang, Yan Zhao, Zhengbin Yan, Qiuxu Wang, Xiaobo Li
Formato:	article
Lenguaje:	EN
Publicado:	Taylor & Francis Group 2021
Materias:	interferon cancer-immunity cycle cancer immunity cancer immunotherapy Immunologic diseases. Allergy RC581-607 Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/204e12bb600b45d78a19457d64a69e0a
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spelling	oai:doaj.org-article:204e12bb600b45d78a19457d64a69e0a2021-12-01T14:40:59ZDouble-edged effects of interferons on the regulation of cancer-immunity cycle2162-402X10.1080/2162402X.2021.1929005https://doaj.org/article/204e12bb600b45d78a19457d64a69e0a2021-01-01T00:00:00Zhttp://dx.doi.org/10.1080/2162402X.2021.1929005https://doaj.org/toc/2162-402XInterferons (IFNs) are a large family of pleiotropic cytokines that regulate both innate and adaptive immunity and show anti-cancer effects in various cancer types. Moreover, it was revealed that IFN signaling plays critical roles in the success of cancer therapy strategies, thereby enhancing their therapeutic effects. However, IFNs have minimal or even adverse effects on cancer eradication, and mediate cancer immune escape in some instances. Thus, IFNs have a double-edged effect on the cancer immune response. Recent studies suggest that IFNs regulate each step of the cancer immunity-cycle, consisting of cancer antigen release, presentation of antigens and activation of T cells, trafficking and infiltration of effector T cells into the tumor microenvironment, and recognition and killing of cancer cells, which contributes to our understanding of the mechanisms of IFNs in regulating cancer immunity. In this review, we focus on IFNs and cancer immunity and elaborate on the roles of IFNs in regulating the cancer-immunity cycle.Xiao ZhangSong WangYuanyuan ZhuMinghui ZhangYan ZhaoZhengbin YanQiuxu WangXiaobo LiTaylor & Francis Grouparticleinterferoncancer-immunity cyclecancer immunitycancer immunotherapyImmunologic diseases. AllergyRC581-607Neoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENOncoImmunology, Vol 10, Iss 1 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	interferon cancer-immunity cycle cancer immunity cancer immunotherapy Immunologic diseases. Allergy RC581-607 Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	interferon cancer-immunity cycle cancer immunity cancer immunotherapy Immunologic diseases. Allergy RC581-607 Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Xiao Zhang Song Wang Yuanyuan Zhu Minghui Zhang Yan Zhao Zhengbin Yan Qiuxu Wang Xiaobo Li Double-edged effects of interferons on the regulation of cancer-immunity cycle
description	Interferons (IFNs) are a large family of pleiotropic cytokines that regulate both innate and adaptive immunity and show anti-cancer effects in various cancer types. Moreover, it was revealed that IFN signaling plays critical roles in the success of cancer therapy strategies, thereby enhancing their therapeutic effects. However, IFNs have minimal or even adverse effects on cancer eradication, and mediate cancer immune escape in some instances. Thus, IFNs have a double-edged effect on the cancer immune response. Recent studies suggest that IFNs regulate each step of the cancer immunity-cycle, consisting of cancer antigen release, presentation of antigens and activation of T cells, trafficking and infiltration of effector T cells into the tumor microenvironment, and recognition and killing of cancer cells, which contributes to our understanding of the mechanisms of IFNs in regulating cancer immunity. In this review, we focus on IFNs and cancer immunity and elaborate on the roles of IFNs in regulating the cancer-immunity cycle.
format	article
author	Xiao Zhang Song Wang Yuanyuan Zhu Minghui Zhang Yan Zhao Zhengbin Yan Qiuxu Wang Xiaobo Li
author_facet	Xiao Zhang Song Wang Yuanyuan Zhu Minghui Zhang Yan Zhao Zhengbin Yan Qiuxu Wang Xiaobo Li
author_sort	Xiao Zhang
title	Double-edged effects of interferons on the regulation of cancer-immunity cycle
title_short	Double-edged effects of interferons on the regulation of cancer-immunity cycle
title_full	Double-edged effects of interferons on the regulation of cancer-immunity cycle
title_fullStr	Double-edged effects of interferons on the regulation of cancer-immunity cycle
title_full_unstemmed	Double-edged effects of interferons on the regulation of cancer-immunity cycle
title_sort	double-edged effects of interferons on the regulation of cancer-immunity cycle
publisher	Taylor & Francis Group
publishDate	2021
url	https://doaj.org/article/204e12bb600b45d78a19457d64a69e0a
work_keys_str_mv	AT xiaozhang doubleedgedeffectsofinterferonsontheregulationofcancerimmunitycycle AT songwang doubleedgedeffectsofinterferonsontheregulationofcancerimmunitycycle AT yuanyuanzhu doubleedgedeffectsofinterferonsontheregulationofcancerimmunitycycle AT minghuizhang doubleedgedeffectsofinterferonsontheregulationofcancerimmunitycycle AT yanzhao doubleedgedeffectsofinterferonsontheregulationofcancerimmunitycycle AT zhengbinyan doubleedgedeffectsofinterferonsontheregulationofcancerimmunitycycle AT qiuxuwang doubleedgedeffectsofinterferonsontheregulationofcancerimmunitycycle AT xiaoboli doubleedgedeffectsofinterferonsontheregulationofcancerimmunitycycle
_version_	1718404980815167488

Double-edged effects of interferons on the regulation of cancer-immunity cycle

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