Pilot study of Tremelimumab with and without cryoablation in patients with metastatic renal cell carcinoma

Anti-CTLA4 therapy has not been comprehensively explored for the treatment of metastatic renal cell carcinoma (mRCC). Here, in a pilot study of anti-CTLA4 therapy with or without cryoablation in mRCC, the authors report that the combination is feasible and enhances immune infiltration in patients wi...

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Autores principales:	Matthew T. Campbell, Surena F. Matin, Alda L. Tam, Rahul A. Sheth, Kamran Ahrar, Rebecca S. Tidwell, Priya Rao, Jose A. Karam, Christopher G. Wood, Nizar M. Tannir, Eric Jonasch, Jianjun Gao, Amado J. Zurita, Amishi Y. Shah, Sonali Jindal, Fei Duan, Sreyashi Basu, Hong Chen, Alexsandra B. Espejo, James P. Allison, Shalini S. Yadav, Padmanee Sharma
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/204efb116032411484ebc80c52f409dc
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spelling	oai:doaj.org-article:204efb116032411484ebc80c52f409dc2021-11-08T11:10:45ZPilot study of Tremelimumab with and without cryoablation in patients with metastatic renal cell carcinoma10.1038/s41467-021-26415-42041-1723https://doaj.org/article/204efb116032411484ebc80c52f409dc2021-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-26415-4https://doaj.org/toc/2041-1723Anti-CTLA4 therapy has not been comprehensively explored for the treatment of metastatic renal cell carcinoma (mRCC). Here, in a pilot study of anti-CTLA4 therapy with or without cryoablation in mRCC, the authors report that the combination is feasible and enhances immune infiltration in patients with metastatic clear cell histology.Matthew T. CampbellSurena F. MatinAlda L. TamRahul A. ShethKamran AhrarRebecca S. TidwellPriya RaoJose A. KaramChristopher G. WoodNizar M. TannirEric JonaschJianjun GaoAmado J. ZuritaAmishi Y. ShahSonali JindalFei DuanSreyashi BasuHong ChenAlexsandra B. EspejoJames P. AllisonShalini S. YadavPadmanee SharmaNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Matthew T. Campbell Surena F. Matin Alda L. Tam Rahul A. Sheth Kamran Ahrar Rebecca S. Tidwell Priya Rao Jose A. Karam Christopher G. Wood Nizar M. Tannir Eric Jonasch Jianjun Gao Amado J. Zurita Amishi Y. Shah Sonali Jindal Fei Duan Sreyashi Basu Hong Chen Alexsandra B. Espejo James P. Allison Shalini S. Yadav Padmanee Sharma Pilot study of Tremelimumab with and without cryoablation in patients with metastatic renal cell carcinoma
description	Anti-CTLA4 therapy has not been comprehensively explored for the treatment of metastatic renal cell carcinoma (mRCC). Here, in a pilot study of anti-CTLA4 therapy with or without cryoablation in mRCC, the authors report that the combination is feasible and enhances immune infiltration in patients with metastatic clear cell histology.
format	article
author	Matthew T. Campbell Surena F. Matin Alda L. Tam Rahul A. Sheth Kamran Ahrar Rebecca S. Tidwell Priya Rao Jose A. Karam Christopher G. Wood Nizar M. Tannir Eric Jonasch Jianjun Gao Amado J. Zurita Amishi Y. Shah Sonali Jindal Fei Duan Sreyashi Basu Hong Chen Alexsandra B. Espejo James P. Allison Shalini S. Yadav Padmanee Sharma
author_facet	Matthew T. Campbell Surena F. Matin Alda L. Tam Rahul A. Sheth Kamran Ahrar Rebecca S. Tidwell Priya Rao Jose A. Karam Christopher G. Wood Nizar M. Tannir Eric Jonasch Jianjun Gao Amado J. Zurita Amishi Y. Shah Sonali Jindal Fei Duan Sreyashi Basu Hong Chen Alexsandra B. Espejo James P. Allison Shalini S. Yadav Padmanee Sharma
author_sort	Matthew T. Campbell
title	Pilot study of Tremelimumab with and without cryoablation in patients with metastatic renal cell carcinoma
title_short	Pilot study of Tremelimumab with and without cryoablation in patients with metastatic renal cell carcinoma
title_full	Pilot study of Tremelimumab with and without cryoablation in patients with metastatic renal cell carcinoma
title_fullStr	Pilot study of Tremelimumab with and without cryoablation in patients with metastatic renal cell carcinoma
title_full_unstemmed	Pilot study of Tremelimumab with and without cryoablation in patients with metastatic renal cell carcinoma
title_sort	pilot study of tremelimumab with and without cryoablation in patients with metastatic renal cell carcinoma
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/204efb116032411484ebc80c52f409dc
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Pilot study of Tremelimumab with and without cryoablation in patients with metastatic renal cell carcinoma

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