Spatial Analyses of Specialized Metabolites: The Key to Studying Function in Hosts

ABSTRACT Microbial communities contribute to a wide variety of biological functions in hosts and have the ability to specifically influence the health of those organisms through production of specialized metabolites. However, the structures or molecular mechanisms related to health or disease in hos...

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Autores principales:	Melissa M. Galey, Laura M. Sanchez
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2018
Materias:	chemical communication imaging mass spectrometry specialized metabolites Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/204efb9a5e04445bb80fb2a7b994ebaf
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spelling	oai:doaj.org-article:204efb9a5e04445bb80fb2a7b994ebaf2021-12-02T18:44:39ZSpatial Analyses of Specialized Metabolites: The Key to Studying Function in Hosts10.1128/mSystems.00148-172379-5077https://doaj.org/article/204efb9a5e04445bb80fb2a7b994ebaf2018-04-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mSystems.00148-17https://doaj.org/toc/2379-5077ABSTRACT Microbial communities contribute to a wide variety of biological functions in hosts and have the ability to specifically influence the health of those organisms through production of specialized metabolites. However, the structures or molecular mechanisms related to health or disease in host-microbe interactions represent a knowledge gap. In order to close this gap, we propose that a combinatory approach, pulling from microbiology and analytical chemistry, be considered to investigate these interactions so as to gain a better understanding of the chemistry being produced. We hypothesize that bacteria alter their chemistry in order to survive and induce specific states in their host organisms. Our lab makes use of imaging mass spectrometry and other analytical techniques to study this chemistry in situ, which provides actionable information to test hypotheses.Melissa M. GaleyLaura M. SanchezAmerican Society for Microbiologyarticlechemical communicationimaging mass spectrometryspecialized metabolitesMicrobiologyQR1-502ENmSystems, Vol 3, Iss 2 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	chemical communication imaging mass spectrometry specialized metabolites Microbiology QR1-502
spellingShingle	chemical communication imaging mass spectrometry specialized metabolites Microbiology QR1-502 Melissa M. Galey Laura M. Sanchez Spatial Analyses of Specialized Metabolites: The Key to Studying Function in Hosts
description	ABSTRACT Microbial communities contribute to a wide variety of biological functions in hosts and have the ability to specifically influence the health of those organisms through production of specialized metabolites. However, the structures or molecular mechanisms related to health or disease in host-microbe interactions represent a knowledge gap. In order to close this gap, we propose that a combinatory approach, pulling from microbiology and analytical chemistry, be considered to investigate these interactions so as to gain a better understanding of the chemistry being produced. We hypothesize that bacteria alter their chemistry in order to survive and induce specific states in their host organisms. Our lab makes use of imaging mass spectrometry and other analytical techniques to study this chemistry in situ, which provides actionable information to test hypotheses.
format	article
author	Melissa M. Galey Laura M. Sanchez
author_facet	Melissa M. Galey Laura M. Sanchez
author_sort	Melissa M. Galey
title	Spatial Analyses of Specialized Metabolites: The Key to Studying Function in Hosts
title_short	Spatial Analyses of Specialized Metabolites: The Key to Studying Function in Hosts
title_full	Spatial Analyses of Specialized Metabolites: The Key to Studying Function in Hosts
title_fullStr	Spatial Analyses of Specialized Metabolites: The Key to Studying Function in Hosts
title_full_unstemmed	Spatial Analyses of Specialized Metabolites: The Key to Studying Function in Hosts
title_sort	spatial analyses of specialized metabolites: the key to studying function in hosts
publisher	American Society for Microbiology
publishDate	2018
url	https://doaj.org/article/204efb9a5e04445bb80fb2a7b994ebaf
work_keys_str_mv	AT melissamgaley spatialanalysesofspecializedmetabolitesthekeytostudyingfunctioninhosts AT lauramsanchez spatialanalysesofspecializedmetabolitesthekeytostudyingfunctioninhosts
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Spatial Analyses of Specialized Metabolites: The Key to Studying Function in Hosts

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