Langerhans cell histiocytosis—a case report

A 17-year-old male presented for dermatologic consultation with slightly elevated reddish papules covered by yellowish scales in the scalp for the last two years and reddish and indurated ulcers in the perineum lasting six months. Additional complaints included polyuria, polydipsia, delay in the de...

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Autores principales:	Thiago Jeunon, Maria Auxiliadora Jeunon Sousa, Nilton Santos-Rodrigues, Raquel Lopes
Formato:	article
Lenguaje:	EN
Publicado:	Mattioli1885 2012
Materias:	Langerhans cell histiocytosis Langerhans cell dermatology histopathology diabetes insipidus hypogonadotropic hypogonadism Dermatology RL1-803
Acceso en línea:	https://doaj.org/article/2050214bd11049629cc3339574568635
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spelling	oai:doaj.org-article:2050214bd11049629cc33395745686352021-11-17T08:33:17ZLangerhans cell histiocytosis—a case report10.5826/dpc.0201a042160-9381https://doaj.org/article/2050214bd11049629cc33395745686352012-01-01T00:00:00Zhttp://dpcj.org/index.php/dpc/article/view/996https://doaj.org/toc/2160-9381 A 17-year-old male presented for dermatologic consultation with slightly elevated reddish papules covered by yellowish scales in the scalp for the last two years and reddish and indurated ulcers in the perineum lasting six months. Additional complaints included polyuria, polydipsia, delay in the development of secondary sexual characteristics and hearing loss of the right ear secondary to a medium otitis. Lesions from scalp and perineum were sampled for histopathologic examination and revealed a dense cellular infiltrate made up of mononuclear cells with conspicuous eosinophilic cytoplasm and large cleaved vesicular nucleus, some of them with shapes resembling the format of a kidney and others reminiscent of coffee beans. Numerous intermingling eosinophils were present. The diagnosis of Langerhans cell histiocytosis was then rendered and confirmed by positive immunostaining of neoplastic cells for anti-CD1a and anti-S100 protein antibodies. The work-up revealed diabetes insipidus, hypogonadotropic hypogonadism, hiperprolactenemia, growing-hormone deficiency and thickness of the pituitary stalk. The patient was treated with prednisone and vinblastin based chemotherapy regimen for six months with complete remission, but presented recurrence of some lesions in the scalp, which were handled with topical mustard and corticosteroids. After chemotherapy, the endocrinologic disturbances were corrected with hormonal replacement therapy. The patient is currently in good health with a follow-up of five years. Thiago JeunonMaria Auxiliadora Jeunon SousaNilton Santos-RodriguesRaquel LopesMattioli1885articleLangerhans cell histiocytosisLangerhans celldermatologyhistopathologydiabetes insipidushypogonadotropic hypogonadismDermatologyRL1-803ENDermatology Practical & Conceptual (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Langerhans cell histiocytosis Langerhans cell dermatology histopathology diabetes insipidus hypogonadotropic hypogonadism Dermatology RL1-803
spellingShingle	Langerhans cell histiocytosis Langerhans cell dermatology histopathology diabetes insipidus hypogonadotropic hypogonadism Dermatology RL1-803 Thiago Jeunon Maria Auxiliadora Jeunon Sousa Nilton Santos-Rodrigues Raquel Lopes Langerhans cell histiocytosis—a case report
description	A 17-year-old male presented for dermatologic consultation with slightly elevated reddish papules covered by yellowish scales in the scalp for the last two years and reddish and indurated ulcers in the perineum lasting six months. Additional complaints included polyuria, polydipsia, delay in the development of secondary sexual characteristics and hearing loss of the right ear secondary to a medium otitis. Lesions from scalp and perineum were sampled for histopathologic examination and revealed a dense cellular infiltrate made up of mononuclear cells with conspicuous eosinophilic cytoplasm and large cleaved vesicular nucleus, some of them with shapes resembling the format of a kidney and others reminiscent of coffee beans. Numerous intermingling eosinophils were present. The diagnosis of Langerhans cell histiocytosis was then rendered and confirmed by positive immunostaining of neoplastic cells for anti-CD1a and anti-S100 protein antibodies. The work-up revealed diabetes insipidus, hypogonadotropic hypogonadism, hiperprolactenemia, growing-hormone deficiency and thickness of the pituitary stalk. The patient was treated with prednisone and vinblastin based chemotherapy regimen for six months with complete remission, but presented recurrence of some lesions in the scalp, which were handled with topical mustard and corticosteroids. After chemotherapy, the endocrinologic disturbances were corrected with hormonal replacement therapy. The patient is currently in good health with a follow-up of five years.
format	article
author	Thiago Jeunon Maria Auxiliadora Jeunon Sousa Nilton Santos-Rodrigues Raquel Lopes
author_facet	Thiago Jeunon Maria Auxiliadora Jeunon Sousa Nilton Santos-Rodrigues Raquel Lopes
author_sort	Thiago Jeunon
title	Langerhans cell histiocytosis—a case report
title_short	Langerhans cell histiocytosis—a case report
title_full	Langerhans cell histiocytosis—a case report
title_fullStr	Langerhans cell histiocytosis—a case report
title_full_unstemmed	Langerhans cell histiocytosis—a case report
title_sort	langerhans cell histiocytosis—a case report
publisher	Mattioli1885
publishDate	2012
url	https://doaj.org/article/2050214bd11049629cc3339574568635
work_keys_str_mv	AT thiagojeunon langerhanscellhistiocytosisacasereport AT mariaauxiliadorajeunonsousa langerhanscellhistiocytosisacasereport AT niltonsantosrodrigues langerhanscellhistiocytosisacasereport AT raquellopes langerhanscellhistiocytosisacasereport
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Langerhans cell histiocytosis—a case report

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