Harmonious genetic combinations rewire regulatory networks and flip gene essentiality

Studying how genetic variants in different genes interact and their combinatorial output is experimentally and analytically challenging. Here, the authors quantify the effects of more than 5000 mutation pairs in the yeast GAL regulatory system, finding that many combinations can be predicted with st...

Description complète

Enregistré dans:

Détails bibliographiques
Auteurs principaux:	Aaron M. New, Ben Lehner
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2019
Sujets:	Science Q
Accès en ligne:	https://doaj.org/article/2051227bac0442f09c7f1f5a4c0848ea
Tags:	Ajouter un tag Pas de tags, Soyez le premier à ajouter un tag!

id	oai:doaj.org-article:2051227bac0442f09c7f1f5a4c0848ea
record_format	dspace
spelling	oai:doaj.org-article:2051227bac0442f09c7f1f5a4c0848ea2021-12-02T15:35:04ZHarmonious genetic combinations rewire regulatory networks and flip gene essentiality10.1038/s41467-019-11523-z2041-1723https://doaj.org/article/2051227bac0442f09c7f1f5a4c0848ea2019-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11523-zhttps://doaj.org/toc/2041-1723Studying how genetic variants in different genes interact and their combinatorial output is experimentally and analytically challenging. Here, the authors quantify the effects of more than 5000 mutation pairs in the yeast GAL regulatory system, finding that many combinations can be predicted with statistical models.Aaron M. NewBen LehnerNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Aaron M. New Ben Lehner Harmonious genetic combinations rewire regulatory networks and flip gene essentiality
description	Studying how genetic variants in different genes interact and their combinatorial output is experimentally and analytically challenging. Here, the authors quantify the effects of more than 5000 mutation pairs in the yeast GAL regulatory system, finding that many combinations can be predicted with statistical models.
format	article
author	Aaron M. New Ben Lehner
author_facet	Aaron M. New Ben Lehner
author_sort	Aaron M. New
title	Harmonious genetic combinations rewire regulatory networks and flip gene essentiality
title_short	Harmonious genetic combinations rewire regulatory networks and flip gene essentiality
title_full	Harmonious genetic combinations rewire regulatory networks and flip gene essentiality
title_fullStr	Harmonious genetic combinations rewire regulatory networks and flip gene essentiality
title_full_unstemmed	Harmonious genetic combinations rewire regulatory networks and flip gene essentiality
title_sort	harmonious genetic combinations rewire regulatory networks and flip gene essentiality
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/2051227bac0442f09c7f1f5a4c0848ea
work_keys_str_mv	AT aaronmnew harmoniousgeneticcombinationsrewireregulatorynetworksandflipgeneessentiality AT benlehner harmoniousgeneticcombinationsrewireregulatorynetworksandflipgeneessentiality
_version_	1718386644825931776

Harmonious genetic combinations rewire regulatory networks and flip gene essentiality

Documents similaires