Immunosenescence and Autoimmunity: Exploiting the T-Cell Receptor Repertoire to Investigate the Impact of Aging on Multiple Sclerosis

T-cell receptor (TCR) repertoire diversity is a determining factor for the immune system capability in fighting infections and preventing autoimmunity. During life, the TCR repertoire diversity progressively declines as a physiological aging progress. The investigation of TCR repertoire dynamics ove...

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Autores principales:	Roberta Amoriello, Alice Mariottini, Clara Ballerini
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	multiple sclerosis T cell receptor (TCR) disease modifying therapies (DMTs) aging autoimmune diseases Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/2052380b31ed4c7cbfdfdf8c9747b72b
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spelling	oai:doaj.org-article:2052380b31ed4c7cbfdfdf8c9747b72b2021-12-02T01:25:40ZImmunosenescence and Autoimmunity: Exploiting the T-Cell Receptor Repertoire to Investigate the Impact of Aging on Multiple Sclerosis1664-322410.3389/fimmu.2021.799380https://doaj.org/article/2052380b31ed4c7cbfdfdf8c9747b72b2021-12-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fimmu.2021.799380/fullhttps://doaj.org/toc/1664-3224T-cell receptor (TCR) repertoire diversity is a determining factor for the immune system capability in fighting infections and preventing autoimmunity. During life, the TCR repertoire diversity progressively declines as a physiological aging progress. The investigation of TCR repertoire dynamics over life represents a powerful tool unraveling the impact of immunosenescence in health and disease. Multiple Sclerosis (MS) is a demyelinating, inflammatory, T-cell mediated autoimmune disease of the Central Nervous System in which age is crucial: it is the most widespread neurological disease among young adults and, furthermore, patients age may impact on MS progression and treatments outcome. Crossing knowledge on the TCR repertoire dynamics over MS patients’ life is fundamental to investigate disease mechanisms, and the advent of high- throughput sequencing (HTS) has significantly increased our knowledge on the topic. Here we report an overview of current literature about the impact of immunosenescence and age-related TCR dynamics variation in autoimmunity, including MS.Roberta AmorielloAlice MariottiniClara BalleriniFrontiers Media S.A.articlemultiple sclerosisT cell receptor (TCR)disease modifying therapies (DMTs)agingautoimmune diseasesImmunologic diseases. AllergyRC581-607ENFrontiers in Immunology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	multiple sclerosis T cell receptor (TCR) disease modifying therapies (DMTs) aging autoimmune diseases Immunologic diseases. Allergy RC581-607
spellingShingle	multiple sclerosis T cell receptor (TCR) disease modifying therapies (DMTs) aging autoimmune diseases Immunologic diseases. Allergy RC581-607 Roberta Amoriello Alice Mariottini Clara Ballerini Immunosenescence and Autoimmunity: Exploiting the T-Cell Receptor Repertoire to Investigate the Impact of Aging on Multiple Sclerosis
description	T-cell receptor (TCR) repertoire diversity is a determining factor for the immune system capability in fighting infections and preventing autoimmunity. During life, the TCR repertoire diversity progressively declines as a physiological aging progress. The investigation of TCR repertoire dynamics over life represents a powerful tool unraveling the impact of immunosenescence in health and disease. Multiple Sclerosis (MS) is a demyelinating, inflammatory, T-cell mediated autoimmune disease of the Central Nervous System in which age is crucial: it is the most widespread neurological disease among young adults and, furthermore, patients age may impact on MS progression and treatments outcome. Crossing knowledge on the TCR repertoire dynamics over MS patients’ life is fundamental to investigate disease mechanisms, and the advent of high- throughput sequencing (HTS) has significantly increased our knowledge on the topic. Here we report an overview of current literature about the impact of immunosenescence and age-related TCR dynamics variation in autoimmunity, including MS.
format	article
author	Roberta Amoriello Alice Mariottini Clara Ballerini
author_facet	Roberta Amoriello Alice Mariottini Clara Ballerini
author_sort	Roberta Amoriello
title	Immunosenescence and Autoimmunity: Exploiting the T-Cell Receptor Repertoire to Investigate the Impact of Aging on Multiple Sclerosis
title_short	Immunosenescence and Autoimmunity: Exploiting the T-Cell Receptor Repertoire to Investigate the Impact of Aging on Multiple Sclerosis
title_full	Immunosenescence and Autoimmunity: Exploiting the T-Cell Receptor Repertoire to Investigate the Impact of Aging on Multiple Sclerosis
title_fullStr	Immunosenescence and Autoimmunity: Exploiting the T-Cell Receptor Repertoire to Investigate the Impact of Aging on Multiple Sclerosis
title_full_unstemmed	Immunosenescence and Autoimmunity: Exploiting the T-Cell Receptor Repertoire to Investigate the Impact of Aging on Multiple Sclerosis
title_sort	immunosenescence and autoimmunity: exploiting the t-cell receptor repertoire to investigate the impact of aging on multiple sclerosis
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/2052380b31ed4c7cbfdfdf8c9747b72b
work_keys_str_mv	AT robertaamoriello immunosenescenceandautoimmunityexploitingthetcellreceptorrepertoiretoinvestigatetheimpactofagingonmultiplesclerosis AT alicemariottini immunosenescenceandautoimmunityexploitingthetcellreceptorrepertoiretoinvestigatetheimpactofagingonmultiplesclerosis AT claraballerini immunosenescenceandautoimmunityexploitingthetcellreceptorrepertoiretoinvestigatetheimpactofagingonmultiplesclerosis
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Immunosenescence and Autoimmunity: Exploiting the T-Cell Receptor Repertoire to Investigate the Impact of Aging on Multiple Sclerosis

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