Embryonic mesothelial-derived hepatic lineage of quiescent and heterogenous scar-orchestrating cells defined but suppressed by WT1

Activated hepatic stellate cells of putative mesodermal origin orchestrate scarring during injury. Here, the authors define a discrete morphologically plastic lineage of embryonic mesothelial-derived scar-orchestrating cells, through a distinct quiescent adult precursor, defined and paradoxically in...

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Autores principales:	Timothy James Kendall, Catherine Mary Duff, Luke Boulter, David H. Wilson, Elisabeth Freyer, Stuart Aitken, Stuart John Forbes, John Peter Iredale, Nicholas Dixon Hastie
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/2053b287b6104ed8b2c5a1835405ee3e
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spelling	oai:doaj.org-article:2053b287b6104ed8b2c5a1835405ee3e2021-12-02T17:01:58ZEmbryonic mesothelial-derived hepatic lineage of quiescent and heterogenous scar-orchestrating cells defined but suppressed by WT110.1038/s41467-019-12701-92041-1723https://doaj.org/article/2053b287b6104ed8b2c5a1835405ee3e2019-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12701-9https://doaj.org/toc/2041-1723Activated hepatic stellate cells of putative mesodermal origin orchestrate scarring during injury. Here, the authors define a discrete morphologically plastic lineage of embryonic mesothelial-derived scar-orchestrating cells, through a distinct quiescent adult precursor, defined and paradoxically inhibited by WT1.Timothy James KendallCatherine Mary DuffLuke BoulterDavid H. WilsonElisabeth FreyerStuart AitkenStuart John ForbesJohn Peter IredaleNicholas Dixon HastieNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-18 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Timothy James Kendall Catherine Mary Duff Luke Boulter David H. Wilson Elisabeth Freyer Stuart Aitken Stuart John Forbes John Peter Iredale Nicholas Dixon Hastie Embryonic mesothelial-derived hepatic lineage of quiescent and heterogenous scar-orchestrating cells defined but suppressed by WT1
description	Activated hepatic stellate cells of putative mesodermal origin orchestrate scarring during injury. Here, the authors define a discrete morphologically plastic lineage of embryonic mesothelial-derived scar-orchestrating cells, through a distinct quiescent adult precursor, defined and paradoxically inhibited by WT1.
format	article
author	Timothy James Kendall Catherine Mary Duff Luke Boulter David H. Wilson Elisabeth Freyer Stuart Aitken Stuart John Forbes John Peter Iredale Nicholas Dixon Hastie
author_facet	Timothy James Kendall Catherine Mary Duff Luke Boulter David H. Wilson Elisabeth Freyer Stuart Aitken Stuart John Forbes John Peter Iredale Nicholas Dixon Hastie
author_sort	Timothy James Kendall
title	Embryonic mesothelial-derived hepatic lineage of quiescent and heterogenous scar-orchestrating cells defined but suppressed by WT1
title_short	Embryonic mesothelial-derived hepatic lineage of quiescent and heterogenous scar-orchestrating cells defined but suppressed by WT1
title_full	Embryonic mesothelial-derived hepatic lineage of quiescent and heterogenous scar-orchestrating cells defined but suppressed by WT1
title_fullStr	Embryonic mesothelial-derived hepatic lineage of quiescent and heterogenous scar-orchestrating cells defined but suppressed by WT1
title_full_unstemmed	Embryonic mesothelial-derived hepatic lineage of quiescent and heterogenous scar-orchestrating cells defined but suppressed by WT1
title_sort	embryonic mesothelial-derived hepatic lineage of quiescent and heterogenous scar-orchestrating cells defined but suppressed by wt1
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/2053b287b6104ed8b2c5a1835405ee3e
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Embryonic mesothelial-derived hepatic lineage of quiescent and heterogenous scar-orchestrating cells defined but suppressed by WT1

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