Citrus allergy from pollen to clinical symptoms.

Allergy to citrus fruits is often associated with pollinosis and sensitization to other plants due to a phenomenon of cross-reactivity. The aims of the present study were to highlight the cross-reactivity among citrus and the major allergenic pollens/fruits, throughout clinical and molecular investi...

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Autores principales:	Rosa Anna Iorio, Stefano Del Duca, Elisabetta Calamelli, Chiara Pula, Magda Lodolini, Fortuna Scamardella, Andrea Pession, Giampaolo Ricci
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/2056991f71ca432fa5766ae0b21ae77c
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spelling	oai:doaj.org-article:2056991f71ca432fa5766ae0b21ae77c2021-11-18T08:02:36ZCitrus allergy from pollen to clinical symptoms.1932-620310.1371/journal.pone.0053680https://doaj.org/article/2056991f71ca432fa5766ae0b21ae77c2013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23308273/?tool=EBIhttps://doaj.org/toc/1932-6203Allergy to citrus fruits is often associated with pollinosis and sensitization to other plants due to a phenomenon of cross-reactivity. The aims of the present study were to highlight the cross-reactivity among citrus and the major allergenic pollens/fruits, throughout clinical and molecular investigations, and to evaluate the sensitization frequency to citrus fruits in a population of children and adults with pollinosis. We found a relevant percentage of sensitisation (39%) to citrus fruits in the patients recruited and in all of them the IgE-mediated mechanism has been confirmed by the positive response to the prick-to-prick test. RT-PCR experiments showed the expression of Cit s 1, Cit s 3 and a profilin isoform, already described in apple, also in Citrus clementine pollen. Data of multiple sequence alignments demonstrated that Citrus allergens shared high percentage identity values with other clinically relevant species (i.e. Triticum aestivum, Malus domestica), confirming the possible cross-allergenicity citrus/grasses and citrus/apple. Finally, a novelty of the present work has been the expression of two phospholipaseA2 isoforms (PLA2 α and β) in Citrus as well as in Triticum pollens; being PLA2 able to generate pro-inflammatory factors, this enzyme could participate in the activation of the allergenic inflammatory cascade.Rosa Anna IorioStefano Del DucaElisabetta CalamelliElisabetta CalamelliChiara PulaMagda LodoliniFortuna ScamardellaAndrea PessionGiampaolo RicciPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 1, p e53680 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Rosa Anna Iorio Stefano Del Duca Elisabetta Calamelli Elisabetta Calamelli Chiara Pula Magda Lodolini Fortuna Scamardella Andrea Pession Giampaolo Ricci Citrus allergy from pollen to clinical symptoms.
description	Allergy to citrus fruits is often associated with pollinosis and sensitization to other plants due to a phenomenon of cross-reactivity. The aims of the present study were to highlight the cross-reactivity among citrus and the major allergenic pollens/fruits, throughout clinical and molecular investigations, and to evaluate the sensitization frequency to citrus fruits in a population of children and adults with pollinosis. We found a relevant percentage of sensitisation (39%) to citrus fruits in the patients recruited and in all of them the IgE-mediated mechanism has been confirmed by the positive response to the prick-to-prick test. RT-PCR experiments showed the expression of Cit s 1, Cit s 3 and a profilin isoform, already described in apple, also in Citrus clementine pollen. Data of multiple sequence alignments demonstrated that Citrus allergens shared high percentage identity values with other clinically relevant species (i.e. Triticum aestivum, Malus domestica), confirming the possible cross-allergenicity citrus/grasses and citrus/apple. Finally, a novelty of the present work has been the expression of two phospholipaseA2 isoforms (PLA2 α and β) in Citrus as well as in Triticum pollens; being PLA2 able to generate pro-inflammatory factors, this enzyme could participate in the activation of the allergenic inflammatory cascade.
format	article
author	Rosa Anna Iorio Stefano Del Duca Elisabetta Calamelli Elisabetta Calamelli Chiara Pula Magda Lodolini Fortuna Scamardella Andrea Pession Giampaolo Ricci
author_facet	Rosa Anna Iorio Stefano Del Duca Elisabetta Calamelli Elisabetta Calamelli Chiara Pula Magda Lodolini Fortuna Scamardella Andrea Pession Giampaolo Ricci
author_sort	Rosa Anna Iorio
title	Citrus allergy from pollen to clinical symptoms.
title_short	Citrus allergy from pollen to clinical symptoms.
title_full	Citrus allergy from pollen to clinical symptoms.
title_fullStr	Citrus allergy from pollen to clinical symptoms.
title_full_unstemmed	Citrus allergy from pollen to clinical symptoms.
title_sort	citrus allergy from pollen to clinical symptoms.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/2056991f71ca432fa5766ae0b21ae77c
work_keys_str_mv	AT rosaannaiorio citrusallergyfrompollentoclinicalsymptoms AT stefanodelduca citrusallergyfrompollentoclinicalsymptoms AT elisabettacalamelli citrusallergyfrompollentoclinicalsymptoms AT elisabettacalamelli citrusallergyfrompollentoclinicalsymptoms AT chiarapula citrusallergyfrompollentoclinicalsymptoms AT magdalodolini citrusallergyfrompollentoclinicalsymptoms AT fortunascamardella citrusallergyfrompollentoclinicalsymptoms AT andreapession citrusallergyfrompollentoclinicalsymptoms AT giampaoloricci citrusallergyfrompollentoclinicalsymptoms
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Citrus allergy from pollen to clinical symptoms.

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