Cullin3-KLHL15 ubiquitin ligase mediates CtIP protein turnover to fine-tune DNA-end resection

CtIP has a key role in DNA double-strand break repair as its role in resecting DNA at the break commits a cell to homologous recombination. Here the authors show that KLHL15 interacts with CtIP and regulates repair by controlling protein turnover.

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Autores principales:	Lorenza P. Ferretti, Sarah-Felicitas Himmels, Anika Trenner, Christina Walker, Christine von Aesch, Aline Eggenschwiler, Olga Murina, Radoslav I. Enchev, Matthias Peter, Raimundo Freire, Antonio Porro, Alessandro A. Sartori
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/205a013d59044243b694ef6cde84318a
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spelling	oai:doaj.org-article:205a013d59044243b694ef6cde84318a2021-12-02T15:34:57ZCullin3-KLHL15 ubiquitin ligase mediates CtIP protein turnover to fine-tune DNA-end resection10.1038/ncomms126282041-1723https://doaj.org/article/205a013d59044243b694ef6cde84318a2016-08-01T00:00:00Zhttps://doi.org/10.1038/ncomms12628https://doaj.org/toc/2041-1723CtIP has a key role in DNA double-strand break repair as its role in resecting DNA at the break commits a cell to homologous recombination. Here the authors show that KLHL15 interacts with CtIP and regulates repair by controlling protein turnover.Lorenza P. FerrettiSarah-Felicitas HimmelsAnika TrennerChristina WalkerChristine von AeschAline EggenschwilerOlga MurinaRadoslav I. EnchevMatthias PeterRaimundo FreireAntonio PorroAlessandro A. SartoriNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-16 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Lorenza P. Ferretti Sarah-Felicitas Himmels Anika Trenner Christina Walker Christine von Aesch Aline Eggenschwiler Olga Murina Radoslav I. Enchev Matthias Peter Raimundo Freire Antonio Porro Alessandro A. Sartori Cullin3-KLHL15 ubiquitin ligase mediates CtIP protein turnover to fine-tune DNA-end resection
description	CtIP has a key role in DNA double-strand break repair as its role in resecting DNA at the break commits a cell to homologous recombination. Here the authors show that KLHL15 interacts with CtIP and regulates repair by controlling protein turnover.
format	article
author	Lorenza P. Ferretti Sarah-Felicitas Himmels Anika Trenner Christina Walker Christine von Aesch Aline Eggenschwiler Olga Murina Radoslav I. Enchev Matthias Peter Raimundo Freire Antonio Porro Alessandro A. Sartori
author_facet	Lorenza P. Ferretti Sarah-Felicitas Himmels Anika Trenner Christina Walker Christine von Aesch Aline Eggenschwiler Olga Murina Radoslav I. Enchev Matthias Peter Raimundo Freire Antonio Porro Alessandro A. Sartori
author_sort	Lorenza P. Ferretti
title	Cullin3-KLHL15 ubiquitin ligase mediates CtIP protein turnover to fine-tune DNA-end resection
title_short	Cullin3-KLHL15 ubiquitin ligase mediates CtIP protein turnover to fine-tune DNA-end resection
title_full	Cullin3-KLHL15 ubiquitin ligase mediates CtIP protein turnover to fine-tune DNA-end resection
title_fullStr	Cullin3-KLHL15 ubiquitin ligase mediates CtIP protein turnover to fine-tune DNA-end resection
title_full_unstemmed	Cullin3-KLHL15 ubiquitin ligase mediates CtIP protein turnover to fine-tune DNA-end resection
title_sort	cullin3-klhl15 ubiquitin ligase mediates ctip protein turnover to fine-tune dna-end resection
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/205a013d59044243b694ef6cde84318a
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Cullin3-KLHL15 ubiquitin ligase mediates CtIP protein turnover to fine-tune DNA-end resection

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