A visual fluoresce covalent organic polymer for precise analysis of Fe3+ in MC3T3-E1 cells: A method for bone disease diagnosis

Precise detection of Fe3+ ions in vitro is important for diagnosis of disease and bone health. Covalent organic polymers (COPs) are chosen as the precision probes, due to their light-weight, stable-bonds, and fast-response. In this work, a new fluorescent COP, pyrene-2,7-diboronic-COP(PD-COP), was d...

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Autores principales:	Wenqiang Li, Changpeng Xu, Lin Huang, Zhiguan Huang, Bin Zhou, Yuhe Li, Jianghui Dong, Liping Wang
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Covalent organic polymer PD-COP Fe3+ concentration Biocompatibility Materials of engineering and construction. Mechanics of materials TA401-492
Acceso en línea:	https://doaj.org/article/205bf608c42744c48ccf41c671cdec3e
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spelling	oai:doaj.org-article:205bf608c42744c48ccf41c671cdec3e2021-11-14T04:28:36ZA visual fluoresce covalent organic polymer for precise analysis of Fe3+ in MC3T3-E1 cells: A method for bone disease diagnosis0264-127510.1016/j.matdes.2021.110243https://doaj.org/article/205bf608c42744c48ccf41c671cdec3e2021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S026412752100798Xhttps://doaj.org/toc/0264-1275Precise detection of Fe3+ ions in vitro is important for diagnosis of disease and bone health. Covalent organic polymers (COPs) are chosen as the precision probes, due to their light-weight, stable-bonds, and fast-response. In this work, a new fluorescent COP, pyrene-2,7-diboronic-COP(PD-COP), was designed and its feasibility in detection of iron concentration in cells was tested. PD-COP showed good performance in selective detection of Fe3+, among other metal ions. Its high anti-interference property and recyclability provide the theoretical basis for practical applications. PD-COP could selectively detect Fe3+ ions with low limit of detection (LOD) at a concentration of about 0.68 µM. The quenching mechanism could be due to the transfer of electron. The in vitro experiments using cells also showed that the PD-COP had good biocompatibility, and the ability to detect Fe3+ ions in cells. In conclusion, we successfully synthesized a novel COP, with high sensitivity that could selectively detect Fe3+ ions. The COP had the ability to enter the cell membrane and combine with iron ions, which provided a new method of monitoring bone health.Wenqiang LiChangpeng XuLin HuangZhiguan HuangBin ZhouYuhe LiJianghui DongLiping WangElsevierarticleCovalent organic polymerPD-COPFe3+ concentrationBiocompatibilityMaterials of engineering and construction. Mechanics of materialsTA401-492ENMaterials & Design, Vol 212, Iss , Pp 110243- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Covalent organic polymer PD-COP Fe3+ concentration Biocompatibility Materials of engineering and construction. Mechanics of materials TA401-492
spellingShingle	Covalent organic polymer PD-COP Fe3+ concentration Biocompatibility Materials of engineering and construction. Mechanics of materials TA401-492 Wenqiang Li Changpeng Xu Lin Huang Zhiguan Huang Bin Zhou Yuhe Li Jianghui Dong Liping Wang A visual fluoresce covalent organic polymer for precise analysis of Fe3+ in MC3T3-E1 cells: A method for bone disease diagnosis
description	Precise detection of Fe3+ ions in vitro is important for diagnosis of disease and bone health. Covalent organic polymers (COPs) are chosen as the precision probes, due to their light-weight, stable-bonds, and fast-response. In this work, a new fluorescent COP, pyrene-2,7-diboronic-COP(PD-COP), was designed and its feasibility in detection of iron concentration in cells was tested. PD-COP showed good performance in selective detection of Fe3+, among other metal ions. Its high anti-interference property and recyclability provide the theoretical basis for practical applications. PD-COP could selectively detect Fe3+ ions with low limit of detection (LOD) at a concentration of about 0.68 µM. The quenching mechanism could be due to the transfer of electron. The in vitro experiments using cells also showed that the PD-COP had good biocompatibility, and the ability to detect Fe3+ ions in cells. In conclusion, we successfully synthesized a novel COP, with high sensitivity that could selectively detect Fe3+ ions. The COP had the ability to enter the cell membrane and combine with iron ions, which provided a new method of monitoring bone health.
format	article
author	Wenqiang Li Changpeng Xu Lin Huang Zhiguan Huang Bin Zhou Yuhe Li Jianghui Dong Liping Wang
author_facet	Wenqiang Li Changpeng Xu Lin Huang Zhiguan Huang Bin Zhou Yuhe Li Jianghui Dong Liping Wang
author_sort	Wenqiang Li
title	A visual fluoresce covalent organic polymer for precise analysis of Fe3+ in MC3T3-E1 cells: A method for bone disease diagnosis
title_short	A visual fluoresce covalent organic polymer for precise analysis of Fe3+ in MC3T3-E1 cells: A method for bone disease diagnosis
title_full	A visual fluoresce covalent organic polymer for precise analysis of Fe3+ in MC3T3-E1 cells: A method for bone disease diagnosis
title_fullStr	A visual fluoresce covalent organic polymer for precise analysis of Fe3+ in MC3T3-E1 cells: A method for bone disease diagnosis
title_full_unstemmed	A visual fluoresce covalent organic polymer for precise analysis of Fe3+ in MC3T3-E1 cells: A method for bone disease diagnosis
title_sort	visual fluoresce covalent organic polymer for precise analysis of fe3+ in mc3t3-e1 cells: a method for bone disease diagnosis
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/205bf608c42744c48ccf41c671cdec3e
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A visual fluoresce covalent organic polymer for precise analysis of Fe3+ in MC3T3-E1 cells: A method for bone disease diagnosis

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