Orengedoku-to augmentation in cases showing partial response to yokukan-san treatment: a case report and literature review of the evidence for use of these Kampo herbal formulae

Hideki Okamoto,1 Atsushi Chino,1 Yoshiro Hirasaki,1 Keigo Ueda,1 Masaomi Iyo,2 Takao Namiki11Department of Japanese-Oriental (Kampo) Medicine, Chiba University Graduate School of Medicine, Chiba City, Japan; 2Department of Psychiatry, Chiba University Graduate School of Medicine, Chiba City, Japan B...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Okamoto H, Chino A, Hirasaki Y, Ueda K, Iyo M, Namiki T
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2013
Materias:	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/2060ee5c68cf4e5aa368572c45f4a921
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:2060ee5c68cf4e5aa368572c45f4a921
record_format	dspace
spelling	oai:doaj.org-article:2060ee5c68cf4e5aa368572c45f4a9212021-12-02T01:00:37ZOrengedoku-to augmentation in cases showing partial response to yokukan-san treatment: a case report and literature review of the evidence for use of these Kampo herbal formulae1176-63281178-2021https://doaj.org/article/2060ee5c68cf4e5aa368572c45f4a9212013-01-01T00:00:00Zhttp://www.dovepress.com/orengedoku-to-augmentation-in-cases-showing-partial-response-to-yokuka-a12006https://doaj.org/toc/1176-6328https://doaj.org/toc/1178-2021Hideki Okamoto,1 Atsushi Chino,1 Yoshiro Hirasaki,1 Keigo Ueda,1 Masaomi Iyo,2 Takao Namiki11Department of Japanese-Oriental (Kampo) Medicine, Chiba University Graduate School of Medicine, Chiba City, Japan; 2Department of Psychiatry, Chiba University Graduate School of Medicine, Chiba City, Japan Background: Yokukan-san, a Japanese traditional herbal (Kampo) prescription, has recently gathered increasing attention due to accumulating reports showing its remarkable efficacy in treating a wide variety of diseases refractory to conventional medicine as well as the behavioral and psychological symptoms of dementia. As yokukan-san has become broadly integrated with conventional medicine, augmentation therapy with other Kampo prescriptions has become necessary when the yokukan-san has been only partially efficacious. In this paper, we report three cases in which the addition of orengedoku-to, another Kampo formula, to yokukan-san was remarkably effective.Cases: Case 1 was an 85-year-old man with Alzheimer-type dementia who had become aggressive during the past 2 years. Three milligrams of aripiprazole completely suppressed his problematic behaviors but had to be stopped because of extrapyramidal symptoms. In the second case, a 44-year-old man with methamphetamine-induced psychosis had suffered from serious tardive dystonia for 2 years. No conventional approach had improved his tardive dystonia. The third case was a 29-year-old engineer who often failed to resist aggressive impulses and was diagnosed with intermittent explosive disorder. He was prescribed 5 mg of olanzapine, which did not suppress his extraordinary anger and caused somnolence even though the dose was low.Interventions and outcomes: Yokukan-san was complementarily added to the patients&#39; regular medication and exerted a definitive but partial effect in all cases. The addition of orengedoku-to to yokukan-san exerted the same efficacy as aripiprazole in controlling aggressiveness in Case 1, improved the tardive dystonia by 80% in Case 2, and was completely effective in controlling the patient&#39;s aggressive impulses in Case 3.Conclusion: Together with empirical evidence demonstrating the effectiveness of both yokukan-san and orengedoku-to in reducing irritability, impulsivity, and aggression, these three cases suggest that orengedoku-to augmentation can be an effective option in cases that are partially responsive to yokukan-san treatment.Keywords: traditional medicine, aggressiveness, tardive dystonia, intermittent explosive disorderOkamoto HChino AHirasaki YUeda KIyo MNamiki TDove Medical PressarticleNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol 2013, Iss default, Pp 151-155 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Okamoto H Chino A Hirasaki Y Ueda K Iyo M Namiki T Orengedoku-to augmentation in cases showing partial response to yokukan-san treatment: a case report and literature review of the evidence for use of these Kampo herbal formulae
description	Hideki Okamoto,1 Atsushi Chino,1 Yoshiro Hirasaki,1 Keigo Ueda,1 Masaomi Iyo,2 Takao Namiki11Department of Japanese-Oriental (Kampo) Medicine, Chiba University Graduate School of Medicine, Chiba City, Japan; 2Department of Psychiatry, Chiba University Graduate School of Medicine, Chiba City, Japan Background: Yokukan-san, a Japanese traditional herbal (Kampo) prescription, has recently gathered increasing attention due to accumulating reports showing its remarkable efficacy in treating a wide variety of diseases refractory to conventional medicine as well as the behavioral and psychological symptoms of dementia. As yokukan-san has become broadly integrated with conventional medicine, augmentation therapy with other Kampo prescriptions has become necessary when the yokukan-san has been only partially efficacious. In this paper, we report three cases in which the addition of orengedoku-to, another Kampo formula, to yokukan-san was remarkably effective.Cases: Case 1 was an 85-year-old man with Alzheimer-type dementia who had become aggressive during the past 2 years. Three milligrams of aripiprazole completely suppressed his problematic behaviors but had to be stopped because of extrapyramidal symptoms. In the second case, a 44-year-old man with methamphetamine-induced psychosis had suffered from serious tardive dystonia for 2 years. No conventional approach had improved his tardive dystonia. The third case was a 29-year-old engineer who often failed to resist aggressive impulses and was diagnosed with intermittent explosive disorder. He was prescribed 5 mg of olanzapine, which did not suppress his extraordinary anger and caused somnolence even though the dose was low.Interventions and outcomes: Yokukan-san was complementarily added to the patients&#39; regular medication and exerted a definitive but partial effect in all cases. The addition of orengedoku-to to yokukan-san exerted the same efficacy as aripiprazole in controlling aggressiveness in Case 1, improved the tardive dystonia by 80% in Case 2, and was completely effective in controlling the patient&#39;s aggressive impulses in Case 3.Conclusion: Together with empirical evidence demonstrating the effectiveness of both yokukan-san and orengedoku-to in reducing irritability, impulsivity, and aggression, these three cases suggest that orengedoku-to augmentation can be an effective option in cases that are partially responsive to yokukan-san treatment.Keywords: traditional medicine, aggressiveness, tardive dystonia, intermittent explosive disorder
format	article
author	Okamoto H Chino A Hirasaki Y Ueda K Iyo M Namiki T
author_facet	Okamoto H Chino A Hirasaki Y Ueda K Iyo M Namiki T
author_sort	Okamoto H
title	Orengedoku-to augmentation in cases showing partial response to yokukan-san treatment: a case report and literature review of the evidence for use of these Kampo herbal formulae
title_short	Orengedoku-to augmentation in cases showing partial response to yokukan-san treatment: a case report and literature review of the evidence for use of these Kampo herbal formulae
title_full	Orengedoku-to augmentation in cases showing partial response to yokukan-san treatment: a case report and literature review of the evidence for use of these Kampo herbal formulae
title_fullStr	Orengedoku-to augmentation in cases showing partial response to yokukan-san treatment: a case report and literature review of the evidence for use of these Kampo herbal formulae
title_full_unstemmed	Orengedoku-to augmentation in cases showing partial response to yokukan-san treatment: a case report and literature review of the evidence for use of these Kampo herbal formulae
title_sort	orengedoku-to augmentation in cases showing partial response to yokukan-san treatment: a case report and literature review of the evidence for use of these kampo herbal formulae
publisher	Dove Medical Press
publishDate	2013
url	https://doaj.org/article/2060ee5c68cf4e5aa368572c45f4a921
work_keys_str_mv	AT okamotoh orengedokutoaugmentationincasesshowingpartialresponsetoyokukansantreatmentacasereportandliteraturereviewoftheevidenceforuseofthesekampoherbalformulae AT chinoa orengedokutoaugmentationincasesshowingpartialresponsetoyokukansantreatmentacasereportandliteraturereviewoftheevidenceforuseofthesekampoherbalformulae AT hirasakiy orengedokutoaugmentationincasesshowingpartialresponsetoyokukansantreatmentacasereportandliteraturereviewoftheevidenceforuseofthesekampoherbalformulae AT uedak orengedokutoaugmentationincasesshowingpartialresponsetoyokukansantreatmentacasereportandliteraturereviewoftheevidenceforuseofthesekampoherbalformulae AT iyom orengedokutoaugmentationincasesshowingpartialresponsetoyokukansantreatmentacasereportandliteraturereviewoftheevidenceforuseofthesekampoherbalformulae AT namikit orengedokutoaugmentationincasesshowingpartialresponsetoyokukansantreatmentacasereportandliteraturereviewoftheevidenceforuseofthesekampoherbalformulae
_version_	1718403370283171840

Orengedoku-to augmentation in cases showing partial response to yokukan-san treatment: a case report and literature review of the evidence for use of these Kampo herbal formulae

Ejemplares similares