Genuine antiplasticizing effect of water on a glass-former drug

Abstract Water is the most important plasticizer of biological and organic hydrophilic materials, which generally exhibit enhanced mechanical softness and molecular mobility upon hydration. The enhancement of the molecular dynamics upon mixing with water, which in glass-forming systems implies a low...

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Autores principales:	Guadalupe N. Ruiz, Michela Romanini, Astrid Hauptmann, Thomas Loerting, Evgenyi Shalaev, Josep Ll. Tamarit, Luis C. Pardo, Roberto Macovez
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/206172ee526846c7a8f67c7d23b70070
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spelling	oai:doaj.org-article:206172ee526846c7a8f67c7d23b700702021-12-02T16:06:08ZGenuine antiplasticizing effect of water on a glass-former drug10.1038/s41598-017-07643-52045-2322https://doaj.org/article/206172ee526846c7a8f67c7d23b700702017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-07643-5https://doaj.org/toc/2045-2322Abstract Water is the most important plasticizer of biological and organic hydrophilic materials, which generally exhibit enhanced mechanical softness and molecular mobility upon hydration. The enhancement of the molecular dynamics upon mixing with water, which in glass-forming systems implies a lower glass transition temperature (T g ), is considered a universal result of hydration. In fact, even in the cases where hydration or humidification of an organic glass-forming sample result in stiffer mechanical properties, the molecular mobility of the sample almost always increases with increasing water content, and its T g decreases correspondingly. Here, we present an experimental report of a genuine antiplasticizing effect of water on the molecular dynamics of a small-molecule glass former. In detail, we show that addition of water to prilocaine, an active pharmaceutical ingredient, has the same effect as that of an applied pressure, namely, a decrease in mobility and an increase of T g . We assign the antiplasticizing effect to the formation of prilocaine-H 2 O dimers or complexes with enhanced hydrogen bonding interactions.Guadalupe N. RuizMichela RomaniniAstrid HauptmannThomas LoertingEvgenyi ShalaevJosep Ll. TamaritLuis C. PardoRoberto MacovezNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-8 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Guadalupe N. Ruiz Michela Romanini Astrid Hauptmann Thomas Loerting Evgenyi Shalaev Josep Ll. Tamarit Luis C. Pardo Roberto Macovez Genuine antiplasticizing effect of water on a glass-former drug
description	Abstract Water is the most important plasticizer of biological and organic hydrophilic materials, which generally exhibit enhanced mechanical softness and molecular mobility upon hydration. The enhancement of the molecular dynamics upon mixing with water, which in glass-forming systems implies a lower glass transition temperature (T g ), is considered a universal result of hydration. In fact, even in the cases where hydration or humidification of an organic glass-forming sample result in stiffer mechanical properties, the molecular mobility of the sample almost always increases with increasing water content, and its T g decreases correspondingly. Here, we present an experimental report of a genuine antiplasticizing effect of water on the molecular dynamics of a small-molecule glass former. In detail, we show that addition of water to prilocaine, an active pharmaceutical ingredient, has the same effect as that of an applied pressure, namely, a decrease in mobility and an increase of T g . We assign the antiplasticizing effect to the formation of prilocaine-H 2 O dimers or complexes with enhanced hydrogen bonding interactions.
format	article
author	Guadalupe N. Ruiz Michela Romanini Astrid Hauptmann Thomas Loerting Evgenyi Shalaev Josep Ll. Tamarit Luis C. Pardo Roberto Macovez
author_facet	Guadalupe N. Ruiz Michela Romanini Astrid Hauptmann Thomas Loerting Evgenyi Shalaev Josep Ll. Tamarit Luis C. Pardo Roberto Macovez
author_sort	Guadalupe N. Ruiz
title	Genuine antiplasticizing effect of water on a glass-former drug
title_short	Genuine antiplasticizing effect of water on a glass-former drug
title_full	Genuine antiplasticizing effect of water on a glass-former drug
title_fullStr	Genuine antiplasticizing effect of water on a glass-former drug
title_full_unstemmed	Genuine antiplasticizing effect of water on a glass-former drug
title_sort	genuine antiplasticizing effect of water on a glass-former drug
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/206172ee526846c7a8f67c7d23b70070
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Genuine antiplasticizing effect of water on a glass-former drug

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