Mesenchymal stem cell therapy for osteoarthritis: current perspectives

Cody C Wyles,1 Matthew T Houdek,2 Atta Behfar,3 Rafael J Sierra,21Mayo Medical School, 2Department of Orthopedic Surgery, 3Division of Cardiovascular Diseases, Mayo Clinic, Rochester, MN, USAAbstract: Osteoarthritis (OA) is a painful chronic condition with a significant impact on quality of life. Th...

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Autores principales:	Wyles CC, Houdek MT, Behfar A, Sierra RJ
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2015
Materias:	Cytology QH573-671
Acceso en línea:	https://doaj.org/article/206661b79c6349cab0a9601a6db8cc51
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spelling	oai:doaj.org-article:206661b79c6349cab0a9601a6db8cc512021-12-02T08:01:03ZMesenchymal stem cell therapy for osteoarthritis: current perspectives1178-6957https://doaj.org/article/206661b79c6349cab0a9601a6db8cc512015-08-01T00:00:00Zhttp://www.dovepress.com/mesenchymal-stem-cell-therapy-for-osteoarthritis-current-perspectives-peer-reviewed-article-SCCAAhttps://doaj.org/toc/1178-6957Cody C Wyles,1 Matthew T Houdek,2 Atta Behfar,3 Rafael J Sierra,21Mayo Medical School, 2Department of Orthopedic Surgery, 3Division of Cardiovascular Diseases, Mayo Clinic, Rochester, MN, USAAbstract: Osteoarthritis (OA) is a painful chronic condition with a significant impact on quality of life. The societal burden imposed by OA is increasing in parallel with the aging population; however, no therapies have demonstrated efficacy in preventing the progression of this degenerative joint disease. Current mainstays of therapy include activity modification, conservative pain management strategies, weight loss, and if necessary, replacement of the affected joint. Mesenchymal stem cells (MSCs) are a multipotent endogenous population of progenitors capable of differentiation to musculoskeletal tissues. MSCs have a well-documented immunomodulatory role, managing the inflammatory response primarily through paracrine signaling. Given these properties, MSCs have been proposed as a potential regenerative cell therapy source for patients with OA. Research efforts are focused on determining the ideal source for derivation, as MSCs are native to several tissues. Furthermore, optimizing the mode of delivery remains a challenge both for appropriate localization of MSCs and for directed guidance toward stemming the local inflammatory process and initiating a regenerative response. Scaffolds and matrices with growth factor adjuvants may prove critical in this effort. The purpose of this review is to summarize the current state of MSC-based therapeutics for OA and discuss potential barriers that must be overcome for successful implementation of cell-based therapy as a routine treatment strategy in orthopedics.Keywords: mesenchymal stem cell, osteoarthritis, treatment, regenerative medicine, cell therapyWyles CCHoudek MTBehfar ASierra RJDove Medical PressarticleCytologyQH573-671ENStem Cells and Cloning: Advances and Applications, Vol 2015, Iss default, Pp 117-124 (2015)
institution	DOAJ
collection	DOAJ
language	EN
topic	Cytology QH573-671
spellingShingle	Cytology QH573-671 Wyles CC Houdek MT Behfar A Sierra RJ Mesenchymal stem cell therapy for osteoarthritis: current perspectives
description	Cody C Wyles,1 Matthew T Houdek,2 Atta Behfar,3 Rafael J Sierra,21Mayo Medical School, 2Department of Orthopedic Surgery, 3Division of Cardiovascular Diseases, Mayo Clinic, Rochester, MN, USAAbstract: Osteoarthritis (OA) is a painful chronic condition with a significant impact on quality of life. The societal burden imposed by OA is increasing in parallel with the aging population; however, no therapies have demonstrated efficacy in preventing the progression of this degenerative joint disease. Current mainstays of therapy include activity modification, conservative pain management strategies, weight loss, and if necessary, replacement of the affected joint. Mesenchymal stem cells (MSCs) are a multipotent endogenous population of progenitors capable of differentiation to musculoskeletal tissues. MSCs have a well-documented immunomodulatory role, managing the inflammatory response primarily through paracrine signaling. Given these properties, MSCs have been proposed as a potential regenerative cell therapy source for patients with OA. Research efforts are focused on determining the ideal source for derivation, as MSCs are native to several tissues. Furthermore, optimizing the mode of delivery remains a challenge both for appropriate localization of MSCs and for directed guidance toward stemming the local inflammatory process and initiating a regenerative response. Scaffolds and matrices with growth factor adjuvants may prove critical in this effort. The purpose of this review is to summarize the current state of MSC-based therapeutics for OA and discuss potential barriers that must be overcome for successful implementation of cell-based therapy as a routine treatment strategy in orthopedics.Keywords: mesenchymal stem cell, osteoarthritis, treatment, regenerative medicine, cell therapy
format	article
author	Wyles CC Houdek MT Behfar A Sierra RJ
author_facet	Wyles CC Houdek MT Behfar A Sierra RJ
author_sort	Wyles CC
title	Mesenchymal stem cell therapy for osteoarthritis: current perspectives
title_short	Mesenchymal stem cell therapy for osteoarthritis: current perspectives
title_full	Mesenchymal stem cell therapy for osteoarthritis: current perspectives
title_fullStr	Mesenchymal stem cell therapy for osteoarthritis: current perspectives
title_full_unstemmed	Mesenchymal stem cell therapy for osteoarthritis: current perspectives
title_sort	mesenchymal stem cell therapy for osteoarthritis: current perspectives
publisher	Dove Medical Press
publishDate	2015
url	https://doaj.org/article/206661b79c6349cab0a9601a6db8cc51
work_keys_str_mv	AT wylescc mesenchymalstemcelltherapyforosteoarthritiscurrentperspectives AT houdekmt mesenchymalstemcelltherapyforosteoarthritiscurrentperspectives AT behfara mesenchymalstemcelltherapyforosteoarthritiscurrentperspectives AT sierrarj mesenchymalstemcelltherapyforosteoarthritiscurrentperspectives
_version_	1718398709616607232

Mesenchymal stem cell therapy for osteoarthritis: current perspectives

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