Adapted tolerance to virus infections in four geographically distinct Varroa destructor-resistant honeybee populations

Abstract The ectoparasitic mite, Varroa destructor, is unarguably the leading cause of honeybee (Apis mellifera) mortality worldwide through its role as a vector for lethal viruses, in particular, strains of the Deformed wing virus (DWV) and Acute bee paralysis virus (ABPV) complexes. Several honeyb...

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Autores principales:	Barbara Locke, Srinivas Thaduri, Jörg G. Stephan, Matthew Low, Tjeerd Blacquière, Bjørn Dahle, Yves Le Conte, Peter Neumann, Joachim R. de Miranda
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/2066ae9e49e34885be331486a42becad
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spelling	oai:doaj.org-article:2066ae9e49e34885be331486a42becad2021-12-02T17:34:35ZAdapted tolerance to virus infections in four geographically distinct Varroa destructor-resistant honeybee populations10.1038/s41598-021-91686-22045-2322https://doaj.org/article/2066ae9e49e34885be331486a42becad2021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-91686-2https://doaj.org/toc/2045-2322Abstract The ectoparasitic mite, Varroa destructor, is unarguably the leading cause of honeybee (Apis mellifera) mortality worldwide through its role as a vector for lethal viruses, in particular, strains of the Deformed wing virus (DWV) and Acute bee paralysis virus (ABPV) complexes. Several honeybee populations across Europe have well-documented adaptations of mite-resistant traits but little is known about host adaptations towards the virus infections vectored by the mite. The aim of this study was to assess and compare the possible contribution of adapted virus tolerance and/or resistance to the enhanced survival of four well-documented mite-resistant honeybee populations from Norway, Sweden, The Netherlands and France, in relation to unselected mite-susceptible honeybees. Caged adult bees and laboratory reared larvae, from colonies of these four populations, were inoculated with DWV and ABPV in a series of feeding infection experiments, while control groups received virus-free food. Virus infections were monitored using RT-qPCR assays in individuals sampled over a time course. In both adults and larvae the DWV and ABPV infection dynamics were nearly identical in all groups, but all mite-resistant honeybee populations had significantly higher survival rates compared to the mite-susceptible honeybees. These results suggest that adapted virus tolerance is an important component of survival mechanisms.Barbara LockeSrinivas ThaduriJörg G. StephanMatthew LowTjeerd BlacquièreBjørn DahleYves Le ContePeter NeumannJoachim R. de MirandaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Barbara Locke Srinivas Thaduri Jörg G. Stephan Matthew Low Tjeerd Blacquière Bjørn Dahle Yves Le Conte Peter Neumann Joachim R. de Miranda Adapted tolerance to virus infections in four geographically distinct Varroa destructor-resistant honeybee populations
description	Abstract The ectoparasitic mite, Varroa destructor, is unarguably the leading cause of honeybee (Apis mellifera) mortality worldwide through its role as a vector for lethal viruses, in particular, strains of the Deformed wing virus (DWV) and Acute bee paralysis virus (ABPV) complexes. Several honeybee populations across Europe have well-documented adaptations of mite-resistant traits but little is known about host adaptations towards the virus infections vectored by the mite. The aim of this study was to assess and compare the possible contribution of adapted virus tolerance and/or resistance to the enhanced survival of four well-documented mite-resistant honeybee populations from Norway, Sweden, The Netherlands and France, in relation to unselected mite-susceptible honeybees. Caged adult bees and laboratory reared larvae, from colonies of these four populations, were inoculated with DWV and ABPV in a series of feeding infection experiments, while control groups received virus-free food. Virus infections were monitored using RT-qPCR assays in individuals sampled over a time course. In both adults and larvae the DWV and ABPV infection dynamics were nearly identical in all groups, but all mite-resistant honeybee populations had significantly higher survival rates compared to the mite-susceptible honeybees. These results suggest that adapted virus tolerance is an important component of survival mechanisms.
format	article
author	Barbara Locke Srinivas Thaduri Jörg G. Stephan Matthew Low Tjeerd Blacquière Bjørn Dahle Yves Le Conte Peter Neumann Joachim R. de Miranda
author_facet	Barbara Locke Srinivas Thaduri Jörg G. Stephan Matthew Low Tjeerd Blacquière Bjørn Dahle Yves Le Conte Peter Neumann Joachim R. de Miranda
author_sort	Barbara Locke
title	Adapted tolerance to virus infections in four geographically distinct Varroa destructor-resistant honeybee populations
title_short	Adapted tolerance to virus infections in four geographically distinct Varroa destructor-resistant honeybee populations
title_full	Adapted tolerance to virus infections in four geographically distinct Varroa destructor-resistant honeybee populations
title_fullStr	Adapted tolerance to virus infections in four geographically distinct Varroa destructor-resistant honeybee populations
title_full_unstemmed	Adapted tolerance to virus infections in four geographically distinct Varroa destructor-resistant honeybee populations
title_sort	adapted tolerance to virus infections in four geographically distinct varroa destructor-resistant honeybee populations
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/2066ae9e49e34885be331486a42becad
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Adapted tolerance to virus infections in four geographically distinct Varroa destructor-resistant honeybee populations

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