Emergence of noise-induced oscillations in the central circadian pacemaker.

Bmal1 is an essential transcriptional activator within the mammalian circadian clock. We report here that the suprachiasmatic nucleus (SCN) of Bmal1-null mutant mice, unexpectedly, generates stochastic oscillations with periods that overlap the circadian range. Dissociated SCN neurons expressed fluc...

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Autores principales:	Caroline H Ko, Yujiro R Yamada, David K Welsh, Ethan D Buhr, Andrew C Liu, Eric E Zhang, Martin R Ralph, Steve A Kay, Daniel B Forger, Joseph S Takahashi
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2010
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/20681a20116348f28b3deda1a36a0b56
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spelling	oai:doaj.org-article:20681a20116348f28b3deda1a36a0b562021-11-18T05:36:29ZEmergence of noise-induced oscillations in the central circadian pacemaker.1544-91731545-788510.1371/journal.pbio.1000513https://doaj.org/article/20681a20116348f28b3deda1a36a0b562010-10-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20967239/?tool=EBIhttps://doaj.org/toc/1544-9173https://doaj.org/toc/1545-7885Bmal1 is an essential transcriptional activator within the mammalian circadian clock. We report here that the suprachiasmatic nucleus (SCN) of Bmal1-null mutant mice, unexpectedly, generates stochastic oscillations with periods that overlap the circadian range. Dissociated SCN neurons expressed fluctuating levels of PER2 detected by bioluminescence imaging but could not generate circadian oscillations intrinsically. Inhibition of intercellular communication or cyclic-AMP signaling in SCN slices, which provide a positive feed-forward signal to drive the intracellular negative feedback loop, abolished the stochastic oscillations. Propagation of this feed-forward signal between SCN neurons then promotes quasi-circadian oscillations that arise as an emergent property of the SCN network. Experimental analysis and mathematical modeling argue that both intercellular coupling and molecular noise are required for the stochastic rhythms, providing a novel biological example of noise-induced oscillations. The emergence of stochastic circadian oscillations from the SCN network in the absence of cell-autonomous circadian oscillatory function highlights a previously unrecognized level of circadian organization.Caroline H KoYujiro R YamadaDavid K WelshEthan D BuhrAndrew C LiuEric E ZhangMartin R RalphSteve A KayDaniel B ForgerJoseph S TakahashiPublic Library of Science (PLoS)articleBiology (General)QH301-705.5ENPLoS Biology, Vol 8, Iss 10, p e1000513 (2010)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Caroline H Ko Yujiro R Yamada David K Welsh Ethan D Buhr Andrew C Liu Eric E Zhang Martin R Ralph Steve A Kay Daniel B Forger Joseph S Takahashi Emergence of noise-induced oscillations in the central circadian pacemaker.
description	Bmal1 is an essential transcriptional activator within the mammalian circadian clock. We report here that the suprachiasmatic nucleus (SCN) of Bmal1-null mutant mice, unexpectedly, generates stochastic oscillations with periods that overlap the circadian range. Dissociated SCN neurons expressed fluctuating levels of PER2 detected by bioluminescence imaging but could not generate circadian oscillations intrinsically. Inhibition of intercellular communication or cyclic-AMP signaling in SCN slices, which provide a positive feed-forward signal to drive the intracellular negative feedback loop, abolished the stochastic oscillations. Propagation of this feed-forward signal between SCN neurons then promotes quasi-circadian oscillations that arise as an emergent property of the SCN network. Experimental analysis and mathematical modeling argue that both intercellular coupling and molecular noise are required for the stochastic rhythms, providing a novel biological example of noise-induced oscillations. The emergence of stochastic circadian oscillations from the SCN network in the absence of cell-autonomous circadian oscillatory function highlights a previously unrecognized level of circadian organization.
format	article
author	Caroline H Ko Yujiro R Yamada David K Welsh Ethan D Buhr Andrew C Liu Eric E Zhang Martin R Ralph Steve A Kay Daniel B Forger Joseph S Takahashi
author_facet	Caroline H Ko Yujiro R Yamada David K Welsh Ethan D Buhr Andrew C Liu Eric E Zhang Martin R Ralph Steve A Kay Daniel B Forger Joseph S Takahashi
author_sort	Caroline H Ko
title	Emergence of noise-induced oscillations in the central circadian pacemaker.
title_short	Emergence of noise-induced oscillations in the central circadian pacemaker.
title_full	Emergence of noise-induced oscillations in the central circadian pacemaker.
title_fullStr	Emergence of noise-induced oscillations in the central circadian pacemaker.
title_full_unstemmed	Emergence of noise-induced oscillations in the central circadian pacemaker.
title_sort	emergence of noise-induced oscillations in the central circadian pacemaker.
publisher	Public Library of Science (PLoS)
publishDate	2010
url	https://doaj.org/article/20681a20116348f28b3deda1a36a0b56
work_keys_str_mv	AT carolinehko emergenceofnoiseinducedoscillationsinthecentralcircadianpacemaker AT yujiroryamada emergenceofnoiseinducedoscillationsinthecentralcircadianpacemaker AT davidkwelsh emergenceofnoiseinducedoscillationsinthecentralcircadianpacemaker AT ethandbuhr emergenceofnoiseinducedoscillationsinthecentralcircadianpacemaker AT andrewcliu emergenceofnoiseinducedoscillationsinthecentralcircadianpacemaker AT ericezhang emergenceofnoiseinducedoscillationsinthecentralcircadianpacemaker AT martinrralph emergenceofnoiseinducedoscillationsinthecentralcircadianpacemaker AT steveakay emergenceofnoiseinducedoscillationsinthecentralcircadianpacemaker AT danielbforger emergenceofnoiseinducedoscillationsinthecentralcircadianpacemaker AT josephstakahashi emergenceofnoiseinducedoscillationsinthecentralcircadianpacemaker
_version_	1718424898292940800

Emergence of noise-induced oscillations in the central circadian pacemaker.

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