Emergence of noise-induced oscillations in the central circadian pacemaker.

Bmal1 is an essential transcriptional activator within the mammalian circadian clock. We report here that the suprachiasmatic nucleus (SCN) of Bmal1-null mutant mice, unexpectedly, generates stochastic oscillations with periods that overlap the circadian range. Dissociated SCN neurons expressed fluc...

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Autores principales: Caroline H Ko, Yujiro R Yamada, David K Welsh, Ethan D Buhr, Andrew C Liu, Eric E Zhang, Martin R Ralph, Steve A Kay, Daniel B Forger, Joseph S Takahashi
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2010
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Acceso en línea:https://doaj.org/article/20681a20116348f28b3deda1a36a0b56
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