Emergence of noise-induced oscillations in the central circadian pacemaker.
Bmal1 is an essential transcriptional activator within the mammalian circadian clock. We report here that the suprachiasmatic nucleus (SCN) of Bmal1-null mutant mice, unexpectedly, generates stochastic oscillations with periods that overlap the circadian range. Dissociated SCN neurons expressed fluc...
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Autores principales: | Caroline H Ko, Yujiro R Yamada, David K Welsh, Ethan D Buhr, Andrew C Liu, Eric E Zhang, Martin R Ralph, Steve A Kay, Daniel B Forger, Joseph S Takahashi |
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Formato: | article |
Lenguaje: | EN |
Publicado: |
Public Library of Science (PLoS)
2010
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Materias: | |
Acceso en línea: | https://doaj.org/article/20681a20116348f28b3deda1a36a0b56 |
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