Attentional set-shifting deficit in Parkinson's disease is associated with prefrontal dysfunction: an FDG-PET study.

The attentional set-shifting deficit that has been observed in Parkinson's disease (PD) has long been considered neuropsychological evidence of the involvement of meso-prefrontal and prefrontal-striatal circuits in cognitive flexibility. However, recent studies have suggested that non-dopaminer...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Yoichi Sawada, Yoshiyuki Nishio, Kyoko Suzuki, Kazumi Hirayama, Atsushi Takeda, Yoshiyuki Hosokai, Toshiyuki Ishioka, Yasuto Itoyama, Shoki Takahashi, Hiroshi Fukuda, Etsuro Mori
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/206c0084408a47ba937248c490508a91
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:206c0084408a47ba937248c490508a91
record_format	dspace
spelling	oai:doaj.org-article:206c0084408a47ba937248c490508a912021-11-18T07:16:04ZAttentional set-shifting deficit in Parkinson's disease is associated with prefrontal dysfunction: an FDG-PET study.1932-620310.1371/journal.pone.0038498https://doaj.org/article/206c0084408a47ba937248c490508a912012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22685575/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203The attentional set-shifting deficit that has been observed in Parkinson's disease (PD) has long been considered neuropsychological evidence of the involvement of meso-prefrontal and prefrontal-striatal circuits in cognitive flexibility. However, recent studies have suggested that non-dopaminergic, posterior cortical pathologies may also contribute to this deficit. Although several neuroimaging studies have addressed this issue, the results of these studies were confounded by the use of tasks that required other cognitive processes in addition to set-shifting, such as rule learning and working memory. In this study, we attempted to identify the neural correlates of the attentional set-shifting deficit in PD using a compound letter task and 18F-fluoro-deoxy-glucose (FDG) positron emission tomography during rest. Shift cost, which is a measure of attentional set-shifting ability, was significantly correlated with hypometabolism in the right dorsolateral prefrontal cortex, including the putative human frontal eye field. Our results provide direct evidence that dysfunction in the dorsolateral prefrontal cortex makes a primary contribution to the attentional set-shifting deficit that has been observed in PD patients.Yoichi SawadaYoshiyuki NishioKyoko SuzukiKazumi HirayamaAtsushi TakedaYoshiyuki HosokaiToshiyuki IshiokaYasuto ItoyamaShoki TakahashiHiroshi FukudaEtsuro MoriPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 6, p e38498 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yoichi Sawada Yoshiyuki Nishio Kyoko Suzuki Kazumi Hirayama Atsushi Takeda Yoshiyuki Hosokai Toshiyuki Ishioka Yasuto Itoyama Shoki Takahashi Hiroshi Fukuda Etsuro Mori Attentional set-shifting deficit in Parkinson's disease is associated with prefrontal dysfunction: an FDG-PET study.
description	The attentional set-shifting deficit that has been observed in Parkinson's disease (PD) has long been considered neuropsychological evidence of the involvement of meso-prefrontal and prefrontal-striatal circuits in cognitive flexibility. However, recent studies have suggested that non-dopaminergic, posterior cortical pathologies may also contribute to this deficit. Although several neuroimaging studies have addressed this issue, the results of these studies were confounded by the use of tasks that required other cognitive processes in addition to set-shifting, such as rule learning and working memory. In this study, we attempted to identify the neural correlates of the attentional set-shifting deficit in PD using a compound letter task and 18F-fluoro-deoxy-glucose (FDG) positron emission tomography during rest. Shift cost, which is a measure of attentional set-shifting ability, was significantly correlated with hypometabolism in the right dorsolateral prefrontal cortex, including the putative human frontal eye field. Our results provide direct evidence that dysfunction in the dorsolateral prefrontal cortex makes a primary contribution to the attentional set-shifting deficit that has been observed in PD patients.
format	article
author	Yoichi Sawada Yoshiyuki Nishio Kyoko Suzuki Kazumi Hirayama Atsushi Takeda Yoshiyuki Hosokai Toshiyuki Ishioka Yasuto Itoyama Shoki Takahashi Hiroshi Fukuda Etsuro Mori
author_facet	Yoichi Sawada Yoshiyuki Nishio Kyoko Suzuki Kazumi Hirayama Atsushi Takeda Yoshiyuki Hosokai Toshiyuki Ishioka Yasuto Itoyama Shoki Takahashi Hiroshi Fukuda Etsuro Mori
author_sort	Yoichi Sawada
title	Attentional set-shifting deficit in Parkinson's disease is associated with prefrontal dysfunction: an FDG-PET study.
title_short	Attentional set-shifting deficit in Parkinson's disease is associated with prefrontal dysfunction: an FDG-PET study.
title_full	Attentional set-shifting deficit in Parkinson's disease is associated with prefrontal dysfunction: an FDG-PET study.
title_fullStr	Attentional set-shifting deficit in Parkinson's disease is associated with prefrontal dysfunction: an FDG-PET study.
title_full_unstemmed	Attentional set-shifting deficit in Parkinson's disease is associated with prefrontal dysfunction: an FDG-PET study.
title_sort	attentional set-shifting deficit in parkinson's disease is associated with prefrontal dysfunction: an fdg-pet study.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/206c0084408a47ba937248c490508a91
work_keys_str_mv	AT yoichisawada attentionalsetshiftingdeficitinparkinsonsdiseaseisassociatedwithprefrontaldysfunctionanfdgpetstudy AT yoshiyukinishio attentionalsetshiftingdeficitinparkinsonsdiseaseisassociatedwithprefrontaldysfunctionanfdgpetstudy AT kyokosuzuki attentionalsetshiftingdeficitinparkinsonsdiseaseisassociatedwithprefrontaldysfunctionanfdgpetstudy AT kazumihirayama attentionalsetshiftingdeficitinparkinsonsdiseaseisassociatedwithprefrontaldysfunctionanfdgpetstudy AT atsushitakeda attentionalsetshiftingdeficitinparkinsonsdiseaseisassociatedwithprefrontaldysfunctionanfdgpetstudy AT yoshiyukihosokai attentionalsetshiftingdeficitinparkinsonsdiseaseisassociatedwithprefrontaldysfunctionanfdgpetstudy AT toshiyukiishioka attentionalsetshiftingdeficitinparkinsonsdiseaseisassociatedwithprefrontaldysfunctionanfdgpetstudy AT yasutoitoyama attentionalsetshiftingdeficitinparkinsonsdiseaseisassociatedwithprefrontaldysfunctionanfdgpetstudy AT shokitakahashi attentionalsetshiftingdeficitinparkinsonsdiseaseisassociatedwithprefrontaldysfunctionanfdgpetstudy AT hiroshifukuda attentionalsetshiftingdeficitinparkinsonsdiseaseisassociatedwithprefrontaldysfunctionanfdgpetstudy AT etsuromori attentionalsetshiftingdeficitinparkinsonsdiseaseisassociatedwithprefrontaldysfunctionanfdgpetstudy
_version_	1718423648891568128

Attentional set-shifting deficit in Parkinson's disease is associated with prefrontal dysfunction: an FDG-PET study.

Ejemplares similares