Association between optic nerve blood flow and objective examinations in glaucoma patients with generalized enlargement disc type

Naoki Chiba, Kazuko Omodaka, Yu Yokoyama, Naoko Aizawa, Satoru Tsuda, Masayuki Yasuda, Takaaki Otomo, Shunji Yokokura, Nobuo Fuse, Toru Nakazawa Department of Ophthalmology, Tohoku University Graduate School of Medicine, Sendai, Japan Background: The purpose of this study was to investigate the corr...

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Autores principales:	Nakazawa T, Fuse N, Yokokura S, Otomo T, Yasuda M, Tsuda S, Aizawa N, Yokoyama Y, Omodaka K, Chiba N
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2011
Materias:	Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/206da37267b2448195ae8f6a9f9dd3ea
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spelling	oai:doaj.org-article:206da37267b2448195ae8f6a9f9dd3ea2021-12-02T07:34:04ZAssociation between optic nerve blood flow and objective examinations in glaucoma patients with generalized enlargement disc type1177-54671177-5483https://doaj.org/article/206da37267b2448195ae8f6a9f9dd3ea2011-10-01T00:00:00Zhttp://www.dovepress.com/association-between-optic-nerve-blood-flow-and-objective-examinations--a8553https://doaj.org/toc/1177-5467https://doaj.org/toc/1177-5483Naoki Chiba, Kazuko Omodaka, Yu Yokoyama, Naoko Aizawa, Satoru Tsuda, Masayuki Yasuda, Takaaki Otomo, Shunji Yokokura, Nobuo Fuse, Toru Nakazawa Department of Ophthalmology, Tohoku University Graduate School of Medicine, Sendai, Japan Background: The purpose of this study was to investigate the correlations between microcirculation in the optic disc, average peripapillary retinal nerve fiber layer thickness cupping parameters, and visual field defects in glaucoma patients with the generalized enlargement disc type. Methods: A total of 38 eyes from 38 glaucoma patients with the generalized enlargement disc type were included. The microcirculation of the optic nerve head was examined with laser speckle flow graphy, and the mean blur rate in all areas, in vessel area, and in tissue area were calculated using the laser speckle flow graphy analyzer software. Average peripapillary retinal nerve fiber layer thickness was measured using Stratus optical coherence tomography, and cupping parameters were accessed using the Heidelberg retina tomograph. The mean deviation in the Humphrey field analyzer (30-2 SITA standard) was analyzed. The correlation between these parameters was evaluated using the Spearman rank correlation coefficient. Results: The correlation coefficient of mean blur rate in all optic disc area to the average peripapillary retinal nerve fiber layer thickness, vertical C/D, and mean deviation were r = 0.7546 (P &lt; 0.0001), r = &ndash;0.6208 (P &lt; 0.0001), and r = 0.6010 (P = 0.0001), respectively. The mean blur rate in tissue area of the optic disc showed r = 0.7305 (P &lt; 0.0001), r = &ndash;0.6438 (P &lt; 0.0001), and r = 0.6338 (P &lt; 0.0001). Conclusion: We found that the mean blur rate in the optic disc was significantly correlated with the average peripapillary retinal nerve fiber layer thickness, vertical C/D, and mean deviation in patients with the generalized enlargement disc type of glaucoma. In particular, the mean blur rate in tissue area was more highly correlated than the vessel area with other results of examination in glaucoma patients with the generalized enlargement disc type. Keywords: ocular blood flow, optic disc type, laser speckle flowgraphy, function, structureNakazawa TFuse NYokokura SOtomo TYasuda MTsuda SAizawa NYokoyama YOmodaka KChiba NDove Medical PressarticleOphthalmologyRE1-994ENClinical Ophthalmology, Vol 2011, Iss default, Pp 1549-1556 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Ophthalmology RE1-994
spellingShingle	Ophthalmology RE1-994 Nakazawa T Fuse N Yokokura S Otomo T Yasuda M Tsuda S Aizawa N Yokoyama Y Omodaka K Chiba N Association between optic nerve blood flow and objective examinations in glaucoma patients with generalized enlargement disc type
description	Naoki Chiba, Kazuko Omodaka, Yu Yokoyama, Naoko Aizawa, Satoru Tsuda, Masayuki Yasuda, Takaaki Otomo, Shunji Yokokura, Nobuo Fuse, Toru Nakazawa Department of Ophthalmology, Tohoku University Graduate School of Medicine, Sendai, Japan Background: The purpose of this study was to investigate the correlations between microcirculation in the optic disc, average peripapillary retinal nerve fiber layer thickness cupping parameters, and visual field defects in glaucoma patients with the generalized enlargement disc type. Methods: A total of 38 eyes from 38 glaucoma patients with the generalized enlargement disc type were included. The microcirculation of the optic nerve head was examined with laser speckle flow graphy, and the mean blur rate in all areas, in vessel area, and in tissue area were calculated using the laser speckle flow graphy analyzer software. Average peripapillary retinal nerve fiber layer thickness was measured using Stratus optical coherence tomography, and cupping parameters were accessed using the Heidelberg retina tomograph. The mean deviation in the Humphrey field analyzer (30-2 SITA standard) was analyzed. The correlation between these parameters was evaluated using the Spearman rank correlation coefficient. Results: The correlation coefficient of mean blur rate in all optic disc area to the average peripapillary retinal nerve fiber layer thickness, vertical C/D, and mean deviation were r = 0.7546 (P &lt; 0.0001), r = &ndash;0.6208 (P &lt; 0.0001), and r = 0.6010 (P = 0.0001), respectively. The mean blur rate in tissue area of the optic disc showed r = 0.7305 (P &lt; 0.0001), r = &ndash;0.6438 (P &lt; 0.0001), and r = 0.6338 (P &lt; 0.0001). Conclusion: We found that the mean blur rate in the optic disc was significantly correlated with the average peripapillary retinal nerve fiber layer thickness, vertical C/D, and mean deviation in patients with the generalized enlargement disc type of glaucoma. In particular, the mean blur rate in tissue area was more highly correlated than the vessel area with other results of examination in glaucoma patients with the generalized enlargement disc type. Keywords: ocular blood flow, optic disc type, laser speckle flowgraphy, function, structure
format	article
author	Nakazawa T Fuse N Yokokura S Otomo T Yasuda M Tsuda S Aizawa N Yokoyama Y Omodaka K Chiba N
author_facet	Nakazawa T Fuse N Yokokura S Otomo T Yasuda M Tsuda S Aizawa N Yokoyama Y Omodaka K Chiba N
author_sort	Nakazawa T
title	Association between optic nerve blood flow and objective examinations in glaucoma patients with generalized enlargement disc type
title_short	Association between optic nerve blood flow and objective examinations in glaucoma patients with generalized enlargement disc type
title_full	Association between optic nerve blood flow and objective examinations in glaucoma patients with generalized enlargement disc type
title_fullStr	Association between optic nerve blood flow and objective examinations in glaucoma patients with generalized enlargement disc type
title_full_unstemmed	Association between optic nerve blood flow and objective examinations in glaucoma patients with generalized enlargement disc type
title_sort	association between optic nerve blood flow and objective examinations in glaucoma patients with generalized enlargement disc type
publisher	Dove Medical Press
publishDate	2011
url	https://doaj.org/article/206da37267b2448195ae8f6a9f9dd3ea
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Association between optic nerve blood flow and objective examinations in glaucoma patients with generalized enlargement disc type

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