Integration of sensory quanta in cuneate nucleus neurons in vivo.

Discriminative touch relies on afferent information carried to the central nervous system by action potentials (spikes) in ensembles of primary afferents bundled in peripheral nerves. These sensory quanta are first processed by the cuneate nucleus before the afferent information is transmitted to br...

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Autores principales:	Fredrik Bengtsson, Romain Brasselet, Roland S Johansson, Angelo Arleo, Henrik Jörntell
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/206f2197745e4858b1bb3781a795ca00
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spelling	oai:doaj.org-article:206f2197745e4858b1bb3781a795ca002021-11-18T07:58:06ZIntegration of sensory quanta in cuneate nucleus neurons in vivo.1932-620310.1371/journal.pone.0056630https://doaj.org/article/206f2197745e4858b1bb3781a795ca002013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23409195/?tool=EBIhttps://doaj.org/toc/1932-6203Discriminative touch relies on afferent information carried to the central nervous system by action potentials (spikes) in ensembles of primary afferents bundled in peripheral nerves. These sensory quanta are first processed by the cuneate nucleus before the afferent information is transmitted to brain networks serving specific perceptual and sensorimotor functions. Here we report data on the integration of primary afferent synaptic inputs obtained with in vivo whole cell patch clamp recordings from the neurons of this nucleus. We find that the synaptic integration in individual cuneate neurons is dominated by 4-8 primary afferent inputs with large synaptic weights. In a simulation we show that the arrangement with a low number of primary afferent inputs can maximize transfer over the cuneate nucleus of information encoded in the spatiotemporal patterns of spikes generated when a human fingertip contact objects. Hence, the observed distributions of synaptic weights support high fidelity transfer of signals from ensembles of tactile afferents. Various anatomical estimates suggest that a cuneate neuron may receive hundreds of primary afferents rather than 4-8. Therefore, we discuss the possibility that adaptation of synaptic weight distribution, possibly involving silent synapses, may function to maximize information transfer in somatosensory pathways.Fredrik BengtssonRomain BrasseletRoland S JohanssonAngelo ArleoHenrik JörntellPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 2, p e56630 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Fredrik Bengtsson Romain Brasselet Roland S Johansson Angelo Arleo Henrik Jörntell Integration of sensory quanta in cuneate nucleus neurons in vivo.
description	Discriminative touch relies on afferent information carried to the central nervous system by action potentials (spikes) in ensembles of primary afferents bundled in peripheral nerves. These sensory quanta are first processed by the cuneate nucleus before the afferent information is transmitted to brain networks serving specific perceptual and sensorimotor functions. Here we report data on the integration of primary afferent synaptic inputs obtained with in vivo whole cell patch clamp recordings from the neurons of this nucleus. We find that the synaptic integration in individual cuneate neurons is dominated by 4-8 primary afferent inputs with large synaptic weights. In a simulation we show that the arrangement with a low number of primary afferent inputs can maximize transfer over the cuneate nucleus of information encoded in the spatiotemporal patterns of spikes generated when a human fingertip contact objects. Hence, the observed distributions of synaptic weights support high fidelity transfer of signals from ensembles of tactile afferents. Various anatomical estimates suggest that a cuneate neuron may receive hundreds of primary afferents rather than 4-8. Therefore, we discuss the possibility that adaptation of synaptic weight distribution, possibly involving silent synapses, may function to maximize information transfer in somatosensory pathways.
format	article
author	Fredrik Bengtsson Romain Brasselet Roland S Johansson Angelo Arleo Henrik Jörntell
author_facet	Fredrik Bengtsson Romain Brasselet Roland S Johansson Angelo Arleo Henrik Jörntell
author_sort	Fredrik Bengtsson
title	Integration of sensory quanta in cuneate nucleus neurons in vivo.
title_short	Integration of sensory quanta in cuneate nucleus neurons in vivo.
title_full	Integration of sensory quanta in cuneate nucleus neurons in vivo.
title_fullStr	Integration of sensory quanta in cuneate nucleus neurons in vivo.
title_full_unstemmed	Integration of sensory quanta in cuneate nucleus neurons in vivo.
title_sort	integration of sensory quanta in cuneate nucleus neurons in vivo.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/206f2197745e4858b1bb3781a795ca00
work_keys_str_mv	AT fredrikbengtsson integrationofsensoryquantaincuneatenucleusneuronsinvivo AT romainbrasselet integrationofsensoryquantaincuneatenucleusneuronsinvivo AT rolandsjohansson integrationofsensoryquantaincuneatenucleusneuronsinvivo AT angeloarleo integrationofsensoryquantaincuneatenucleusneuronsinvivo AT henrikjorntell integrationofsensoryquantaincuneatenucleusneuronsinvivo
_version_	1718422652738076672

Integration of sensory quanta in cuneate nucleus neurons in vivo.

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