Neurodegenerative Disorders: Spotlight on Sphingolipids

Neurodegenerative diseases are incurable diseases of the nervous system that lead to a progressive loss of brain areas and neuronal subtypes, which is associated with an increase in symptoms that can be linked to the affected brain areas. The key findings that appear in many neurodegenerative diseas...

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Autores principales:	Frida Mandik, Melissa Vos
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	sphingolipids ceramide neurodegeneration NBIA Parkinson’s disease Biology (General) QH301-705.5 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/2078e579278f4cdf9cd4516936b2f8e2
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spelling	oai:doaj.org-article:2078e579278f4cdf9cd4516936b2f8e22021-11-11T17:24:44ZNeurodegenerative Disorders: Spotlight on Sphingolipids10.3390/ijms2221119981422-00671661-6596https://doaj.org/article/2078e579278f4cdf9cd4516936b2f8e22021-11-01T00:00:00Zhttps://www.mdpi.com/1422-0067/22/21/11998https://doaj.org/toc/1661-6596https://doaj.org/toc/1422-0067Neurodegenerative diseases are incurable diseases of the nervous system that lead to a progressive loss of brain areas and neuronal subtypes, which is associated with an increase in symptoms that can be linked to the affected brain areas. The key findings that appear in many neurodegenerative diseases are deposits of proteins and the damage of mitochondria, which mainly affect energy production and mitophagy. Several causative gene mutations have been identified in various neurodegenerative diseases; however, a large proportion are considered sporadic. In the last decade, studies linking lipids, and in particular sphingolipids, to neurodegenerative diseases have shown the importance of these sphingolipids in the underlying pathogenesis. Sphingolipids are bioactive lipids consisting of a sphingoid base linked to a fatty acid and a hydrophilic head group. They are involved in various cellular processes, such as cell growth, apoptosis, and autophagy, and are an essential component of the brain. In this review, we will cover key findings that demonstrate the relevance of sphingolipids in neurodegenerative diseases and will focus on neurodegeneration with brain iron accumulation and Parkinson’s disease.Frida MandikMelissa VosMDPI AGarticlesphingolipidsceramideneurodegenerationNBIAParkinson’s diseaseBiology (General)QH301-705.5ChemistryQD1-999ENInternational Journal of Molecular Sciences, Vol 22, Iss 11998, p 11998 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	sphingolipids ceramide neurodegeneration NBIA Parkinson’s disease Biology (General) QH301-705.5 Chemistry QD1-999
spellingShingle	sphingolipids ceramide neurodegeneration NBIA Parkinson’s disease Biology (General) QH301-705.5 Chemistry QD1-999 Frida Mandik Melissa Vos Neurodegenerative Disorders: Spotlight on Sphingolipids
description	Neurodegenerative diseases are incurable diseases of the nervous system that lead to a progressive loss of brain areas and neuronal subtypes, which is associated with an increase in symptoms that can be linked to the affected brain areas. The key findings that appear in many neurodegenerative diseases are deposits of proteins and the damage of mitochondria, which mainly affect energy production and mitophagy. Several causative gene mutations have been identified in various neurodegenerative diseases; however, a large proportion are considered sporadic. In the last decade, studies linking lipids, and in particular sphingolipids, to neurodegenerative diseases have shown the importance of these sphingolipids in the underlying pathogenesis. Sphingolipids are bioactive lipids consisting of a sphingoid base linked to a fatty acid and a hydrophilic head group. They are involved in various cellular processes, such as cell growth, apoptosis, and autophagy, and are an essential component of the brain. In this review, we will cover key findings that demonstrate the relevance of sphingolipids in neurodegenerative diseases and will focus on neurodegeneration with brain iron accumulation and Parkinson’s disease.
format	article
author	Frida Mandik Melissa Vos
author_facet	Frida Mandik Melissa Vos
author_sort	Frida Mandik
title	Neurodegenerative Disorders: Spotlight on Sphingolipids
title_short	Neurodegenerative Disorders: Spotlight on Sphingolipids
title_full	Neurodegenerative Disorders: Spotlight on Sphingolipids
title_fullStr	Neurodegenerative Disorders: Spotlight on Sphingolipids
title_full_unstemmed	Neurodegenerative Disorders: Spotlight on Sphingolipids
title_sort	neurodegenerative disorders: spotlight on sphingolipids
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/2078e579278f4cdf9cd4516936b2f8e2
work_keys_str_mv	AT fridamandik neurodegenerativedisordersspotlightonsphingolipids AT melissavos neurodegenerativedisordersspotlightonsphingolipids
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Neurodegenerative Disorders: Spotlight on Sphingolipids

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