Superior visible light antimicrobial performance of facet engineered cobalt doped TiO2 mesocrystals in pathogenic bacterium and fungi

Abstract Pristine and Co-doped TiO2 mesocrystals have been synthesized via a simple sol–gel method and their antimicrobial activity has been investigated. The antimicrobial performance was evaluated in terms of zone of inhibition, minimum inhibitory concentration (MIC), antibiofilm activity, and eff...

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Autores principales:	Ayat N. El-Shazly, Gharieb S. El-Sayyad, Aiat H. Hegazy, Mahmoud A. Hamza, Rasha M. Fathy, E. T. El Shenawy, Nageh K. Allam
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/207a68a0d15d440084516370d443ae46
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spelling	oai:doaj.org-article:207a68a0d15d440084516370d443ae462021-12-02T13:35:03ZSuperior visible light antimicrobial performance of facet engineered cobalt doped TiO2 mesocrystals in pathogenic bacterium and fungi10.1038/s41598-021-84989-x2045-2322https://doaj.org/article/207a68a0d15d440084516370d443ae462021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-84989-xhttps://doaj.org/toc/2045-2322Abstract Pristine and Co-doped TiO2 mesocrystals have been synthesized via a simple sol–gel method and their antimicrobial activity has been investigated. The antimicrobial performance was evaluated in terms of zone of inhibition, minimum inhibitory concentration (MIC), antibiofilm activity, and effect of UV illumination in liquid media. The Co-doped TiO2 mesocrystals showed very promising MIC of 0.390 μg/mL and 0.781 μg/mL for P. mirabilis and P. mirabilis, respectively. Additionally, the material showed an MIC of 12.5 μg/mL against C. albicans, suggesting its use as antifungal agent. Upon the addition of 10.0 µg/mL of Co-doped TiO2 mesocrystals, the biofilm inhibition% reaches 84.43% for P. aeruginosa, 78.58% for P. mirabilis, and 77.81% for S. typhi, which can be ascribed to the created active oxygen species that decompose the tested microbial cells upon illumination. Thus the fabricated Co-doped TiO2 mesocrystals exhibit sufficient antimicrobial features under visible light, qualifying them for use as antimicrobial agents against pathogenic bacteria and fungi and subsequently inhibit their hazardous effects.Ayat N. El-ShazlyGharieb S. El-SayyadAiat H. HegazyMahmoud A. HamzaRasha M. FathyE. T. El ShenawyNageh K. AllamNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ayat N. El-Shazly Gharieb S. El-Sayyad Aiat H. Hegazy Mahmoud A. Hamza Rasha M. Fathy E. T. El Shenawy Nageh K. Allam Superior visible light antimicrobial performance of facet engineered cobalt doped TiO2 mesocrystals in pathogenic bacterium and fungi
description	Abstract Pristine and Co-doped TiO2 mesocrystals have been synthesized via a simple sol–gel method and their antimicrobial activity has been investigated. The antimicrobial performance was evaluated in terms of zone of inhibition, minimum inhibitory concentration (MIC), antibiofilm activity, and effect of UV illumination in liquid media. The Co-doped TiO2 mesocrystals showed very promising MIC of 0.390 μg/mL and 0.781 μg/mL for P. mirabilis and P. mirabilis, respectively. Additionally, the material showed an MIC of 12.5 μg/mL against C. albicans, suggesting its use as antifungal agent. Upon the addition of 10.0 µg/mL of Co-doped TiO2 mesocrystals, the biofilm inhibition% reaches 84.43% for P. aeruginosa, 78.58% for P. mirabilis, and 77.81% for S. typhi, which can be ascribed to the created active oxygen species that decompose the tested microbial cells upon illumination. Thus the fabricated Co-doped TiO2 mesocrystals exhibit sufficient antimicrobial features under visible light, qualifying them for use as antimicrobial agents against pathogenic bacteria and fungi and subsequently inhibit their hazardous effects.
format	article
author	Ayat N. El-Shazly Gharieb S. El-Sayyad Aiat H. Hegazy Mahmoud A. Hamza Rasha M. Fathy E. T. El Shenawy Nageh K. Allam
author_facet	Ayat N. El-Shazly Gharieb S. El-Sayyad Aiat H. Hegazy Mahmoud A. Hamza Rasha M. Fathy E. T. El Shenawy Nageh K. Allam
author_sort	Ayat N. El-Shazly
title	Superior visible light antimicrobial performance of facet engineered cobalt doped TiO2 mesocrystals in pathogenic bacterium and fungi
title_short	Superior visible light antimicrobial performance of facet engineered cobalt doped TiO2 mesocrystals in pathogenic bacterium and fungi
title_full	Superior visible light antimicrobial performance of facet engineered cobalt doped TiO2 mesocrystals in pathogenic bacterium and fungi
title_fullStr	Superior visible light antimicrobial performance of facet engineered cobalt doped TiO2 mesocrystals in pathogenic bacterium and fungi
title_full_unstemmed	Superior visible light antimicrobial performance of facet engineered cobalt doped TiO2 mesocrystals in pathogenic bacterium and fungi
title_sort	superior visible light antimicrobial performance of facet engineered cobalt doped tio2 mesocrystals in pathogenic bacterium and fungi
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/207a68a0d15d440084516370d443ae46
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Superior visible light antimicrobial performance of facet engineered cobalt doped TiO2 mesocrystals in pathogenic bacterium and fungi

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