Pancreatic Injury in Patients with SARS-Cov-2 (COVID-19) Infection: A Retrospective Analysis of CT Findings

Objective. To determine the association between COVID-19 infection and peripancreatic changes on CT as a sign of acute pancreatic injury. Methods. Retrospective analysis of CT examinations in patients with confirmed COVID-19 infection yielded 103 instances. An age- and gender-matched cohort of patie...

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Autores principales:	Gabriela Grusova, Radan Bruha, Bianka Bircakova, Matej Novak, Lukas Lambert, Pavel Michalek, Grus Tomas, Andrea Burgetova
Formato:	article
Lenguaje:	EN
Publicado:	Hindawi Limited 2021
Materias:	Diseases of the digestive system. Gastroenterology RC799-869
Acceso en línea:	https://doaj.org/article/207ba762220a449786b131b6b61ebdf0
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spelling	oai:doaj.org-article:207ba762220a449786b131b6b61ebdf02021-11-08T02:36:41ZPancreatic Injury in Patients with SARS-Cov-2 (COVID-19) Infection: A Retrospective Analysis of CT Findings1687-630X10.1155/2021/5390337https://doaj.org/article/207ba762220a449786b131b6b61ebdf02021-01-01T00:00:00Zhttp://dx.doi.org/10.1155/2021/5390337https://doaj.org/toc/1687-630XObjective. To determine the association between COVID-19 infection and peripancreatic changes on CT as a sign of acute pancreatic injury. Methods. Retrospective analysis of CT examinations in patients with confirmed COVID-19 infection yielded 103 instances. An age- and gender-matched cohort of patients without COVID-19 was found. CT examinations were evaluated for peripancreatic stranding or edema, fluid collection, or necrosis, without any other explanation. Depicted pulmonary parenchyma was evaluated for possible COVID-19-related changes. Clinical and laboratory data were retrieved from the clinical database. Results. Peripancreatic fat stranding (n=8) or fluid collection (n=2) without any other cause was found in 10 (10%) patients. Abdominal complaints were reported in 4 (40%) patients. Elevated serum amylase or lipase levels were documented in 5 (50%) patients who also satisfied the diagnostic criteria for acute pancreatitis. From the study sample of 103 patients with COVID-19, pulmonary parenchyma was depicted in 102 (99%), and from these, 57 (55%) had an evidence of pulmonary changes compatible with COVID-19 pneumonia. This proportion was not significantly different between patients with and without peripancreatic changes (p=0.35). In the matched cohort, we found peripancreatic changes in 2 (2%, p=0.033) patients. Patients with pancreatic injury and elevated amylase levels were more likely to require orotracheal intubation (35% vs. 12%, p=0.021). Conclusions. We showed that the prevalence of peripancreatic stranding or fluid collection is higher in patients diagnosed with COVID-19 infection compared to an age- and gender-matched cohort. Patients with pancreatic injury and elevated amylase levels are more likely to require orotracheal intubation. Our findings corroborate the link between COVID-19 infection and pancreatic injury from the perspective of imaging.Gabriela GrusovaRadan BruhaBianka BircakovaMatej NovakLukas LambertPavel MichalekGrus TomasAndrea BurgetovaHindawi LimitedarticleDiseases of the digestive system. GastroenterologyRC799-869ENGastroenterology Research and Practice, Vol 2021 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Diseases of the digestive system. Gastroenterology RC799-869
spellingShingle	Diseases of the digestive system. Gastroenterology RC799-869 Gabriela Grusova Radan Bruha Bianka Bircakova Matej Novak Lukas Lambert Pavel Michalek Grus Tomas Andrea Burgetova Pancreatic Injury in Patients with SARS-Cov-2 (COVID-19) Infection: A Retrospective Analysis of CT Findings
description	Objective. To determine the association between COVID-19 infection and peripancreatic changes on CT as a sign of acute pancreatic injury. Methods. Retrospective analysis of CT examinations in patients with confirmed COVID-19 infection yielded 103 instances. An age- and gender-matched cohort of patients without COVID-19 was found. CT examinations were evaluated for peripancreatic stranding or edema, fluid collection, or necrosis, without any other explanation. Depicted pulmonary parenchyma was evaluated for possible COVID-19-related changes. Clinical and laboratory data were retrieved from the clinical database. Results. Peripancreatic fat stranding (n=8) or fluid collection (n=2) without any other cause was found in 10 (10%) patients. Abdominal complaints were reported in 4 (40%) patients. Elevated serum amylase or lipase levels were documented in 5 (50%) patients who also satisfied the diagnostic criteria for acute pancreatitis. From the study sample of 103 patients with COVID-19, pulmonary parenchyma was depicted in 102 (99%), and from these, 57 (55%) had an evidence of pulmonary changes compatible with COVID-19 pneumonia. This proportion was not significantly different between patients with and without peripancreatic changes (p=0.35). In the matched cohort, we found peripancreatic changes in 2 (2%, p=0.033) patients. Patients with pancreatic injury and elevated amylase levels were more likely to require orotracheal intubation (35% vs. 12%, p=0.021). Conclusions. We showed that the prevalence of peripancreatic stranding or fluid collection is higher in patients diagnosed with COVID-19 infection compared to an age- and gender-matched cohort. Patients with pancreatic injury and elevated amylase levels are more likely to require orotracheal intubation. Our findings corroborate the link between COVID-19 infection and pancreatic injury from the perspective of imaging.
format	article
author	Gabriela Grusova Radan Bruha Bianka Bircakova Matej Novak Lukas Lambert Pavel Michalek Grus Tomas Andrea Burgetova
author_facet	Gabriela Grusova Radan Bruha Bianka Bircakova Matej Novak Lukas Lambert Pavel Michalek Grus Tomas Andrea Burgetova
author_sort	Gabriela Grusova
title	Pancreatic Injury in Patients with SARS-Cov-2 (COVID-19) Infection: A Retrospective Analysis of CT Findings
title_short	Pancreatic Injury in Patients with SARS-Cov-2 (COVID-19) Infection: A Retrospective Analysis of CT Findings
title_full	Pancreatic Injury in Patients with SARS-Cov-2 (COVID-19) Infection: A Retrospective Analysis of CT Findings
title_fullStr	Pancreatic Injury in Patients with SARS-Cov-2 (COVID-19) Infection: A Retrospective Analysis of CT Findings
title_full_unstemmed	Pancreatic Injury in Patients with SARS-Cov-2 (COVID-19) Infection: A Retrospective Analysis of CT Findings
title_sort	pancreatic injury in patients with sars-cov-2 (covid-19) infection: a retrospective analysis of ct findings
publisher	Hindawi Limited
publishDate	2021
url	https://doaj.org/article/207ba762220a449786b131b6b61ebdf0
work_keys_str_mv	AT gabrielagrusova pancreaticinjuryinpatientswithsarscov2covid19infectionaretrospectiveanalysisofctfindings AT radanbruha pancreaticinjuryinpatientswithsarscov2covid19infectionaretrospectiveanalysisofctfindings AT biankabircakova pancreaticinjuryinpatientswithsarscov2covid19infectionaretrospectiveanalysisofctfindings AT matejnovak pancreaticinjuryinpatientswithsarscov2covid19infectionaretrospectiveanalysisofctfindings AT lukaslambert pancreaticinjuryinpatientswithsarscov2covid19infectionaretrospectiveanalysisofctfindings AT pavelmichalek pancreaticinjuryinpatientswithsarscov2covid19infectionaretrospectiveanalysisofctfindings AT grustomas pancreaticinjuryinpatientswithsarscov2covid19infectionaretrospectiveanalysisofctfindings AT andreaburgetova pancreaticinjuryinpatientswithsarscov2covid19infectionaretrospectiveanalysisofctfindings
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Pancreatic Injury in Patients with SARS-Cov-2 (COVID-19) Infection: A Retrospective Analysis of CT Findings

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