Breast cancer and amyloid bodies: is there a role for amyloidosis in cancer-cell dormancy?

Gerald J Mizejewski Wadsworth Center, New York State Department of Health, Albany, NY, USA Abstract: Breast cancer and Alzheimer’s disease (AD) are major causes of death in older women. Interestingly, breast cancer occurs less frequently in AD patients than in the general...

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Autor principal:	Mizejewski GJ
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2017
Materias:	Alpha-fetoprotein non-coding RNA amyloid bodies dormancy breast cancer Alzheimer’s disease Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/2080831903f047d6a30e94ff839d1073
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spelling	oai:doaj.org-article:2080831903f047d6a30e94ff839d10732021-12-02T00:16:49ZBreast cancer and amyloid bodies: is there a role for amyloidosis in cancer-cell dormancy?1179-1314https://doaj.org/article/2080831903f047d6a30e94ff839d10732017-04-01T00:00:00Zhttps://www.dovepress.com/breast-cancer-and-amyloid-bodies-is-there-a-role-for-amyloidosis-in-ca-peer-reviewed-article-BCTThttps://doaj.org/toc/1179-1314Gerald J Mizejewski Wadsworth Center, New York State Department of Health, Albany, NY, USA Abstract: Breast cancer and Alzheimer’s disease (AD) are major causes of death in older women. Interestingly, breast cancer occurs less frequently in AD patients than in the general population. Amyloidosis, the aggregation of amyloid proteins to form amyloid bodies, plays a central role in the pathogenesis of AD and other human neuropathies by forming intracellular fibrillary proteins. Contrary to popular belief, amyloidosis is a common occurrence in mammalian cells, and has recently been reported to be a natural physiological process in response to environmental stress stimulations (such as pH and temperature extremes, hypoxia, and oxidative stress). Many proteins contain an intrinsic “amyloid-converting motif”, which acts in conjunction with a specific noncoding RNA to induce formation of proteinaceous amyloid bodies that are stored in intracellular bundles. In cancer cells such as breast and prostate, the process of amyloidosis induces cells to enter a dormant or resting stage devoid of cell division and proliferation. Therefore, cancer cells undergo growth cessation and enter a dormant stage following amyloidosis in the cell; this is akin to giving the cell AD to cease growth. Keywords: α-fetoprotein, noncoding RNA, amyloid bodies, dormancy, breast cancer, Alzheimer’s diseaseMizejewski GJDove Medical PressarticleAlpha-fetoproteinnon-coding RNAamyloid bodiesdormancybreast cancerAlzheimer’s diseaseNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENBreast Cancer: Targets and Therapy, Vol Volume 9, Pp 287-291 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Alpha-fetoprotein non-coding RNA amyloid bodies dormancy breast cancer Alzheimer’s disease Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	Alpha-fetoprotein non-coding RNA amyloid bodies dormancy breast cancer Alzheimer’s disease Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Mizejewski GJ Breast cancer and amyloid bodies: is there a role for amyloidosis in cancer-cell dormancy?
description	Gerald J Mizejewski Wadsworth Center, New York State Department of Health, Albany, NY, USA Abstract: Breast cancer and Alzheimer’s disease (AD) are major causes of death in older women. Interestingly, breast cancer occurs less frequently in AD patients than in the general population. Amyloidosis, the aggregation of amyloid proteins to form amyloid bodies, plays a central role in the pathogenesis of AD and other human neuropathies by forming intracellular fibrillary proteins. Contrary to popular belief, amyloidosis is a common occurrence in mammalian cells, and has recently been reported to be a natural physiological process in response to environmental stress stimulations (such as pH and temperature extremes, hypoxia, and oxidative stress). Many proteins contain an intrinsic “amyloid-converting motif”, which acts in conjunction with a specific noncoding RNA to induce formation of proteinaceous amyloid bodies that are stored in intracellular bundles. In cancer cells such as breast and prostate, the process of amyloidosis induces cells to enter a dormant or resting stage devoid of cell division and proliferation. Therefore, cancer cells undergo growth cessation and enter a dormant stage following amyloidosis in the cell; this is akin to giving the cell AD to cease growth. Keywords: α-fetoprotein, noncoding RNA, amyloid bodies, dormancy, breast cancer, Alzheimer’s disease
format	article
author	Mizejewski GJ
author_facet	Mizejewski GJ
author_sort	Mizejewski GJ
title	Breast cancer and amyloid bodies: is there a role for amyloidosis in cancer-cell dormancy?
title_short	Breast cancer and amyloid bodies: is there a role for amyloidosis in cancer-cell dormancy?
title_full	Breast cancer and amyloid bodies: is there a role for amyloidosis in cancer-cell dormancy?
title_fullStr	Breast cancer and amyloid bodies: is there a role for amyloidosis in cancer-cell dormancy?
title_full_unstemmed	Breast cancer and amyloid bodies: is there a role for amyloidosis in cancer-cell dormancy?
title_sort	breast cancer and amyloid bodies: is there a role for amyloidosis in cancer-cell dormancy?
publisher	Dove Medical Press
publishDate	2017
url	https://doaj.org/article/2080831903f047d6a30e94ff839d1073
work_keys_str_mv	AT mizejewskigj breastcancerandamyloidbodiesistherearoleforamyloidosisincancercelldormancy
_version_	1718403788071501824

Breast cancer and amyloid bodies: is there a role for amyloidosis in cancer-cell dormancy?

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