D25V apolipoprotein C-III variant causes dominant hereditary systemic amyloidosis and confers cardiovascular protective lipoprotein profile
Decrease in Apolipoprotein C-III (ApoC-III) yields a cardioprotective lipoprotein profile. Here, Valleix et al.reveal a novel ApoC-III variant conferring low plasma ApoC-III concentration and cardioprotection despite renal insufficiency, and, unexpectedly, causing dominant hereditary systemic amyloi...
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Nature Portfolio
2016
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oai:doaj.org-article:20852c4360d64aac8c27c28e258ec6482021-12-02T16:49:58ZD25V apolipoprotein C-III variant causes dominant hereditary systemic amyloidosis and confers cardiovascular protective lipoprotein profile10.1038/ncomms103532041-1723https://doaj.org/article/20852c4360d64aac8c27c28e258ec6482016-01-01T00:00:00Zhttps://doi.org/10.1038/ncomms10353https://doaj.org/toc/2041-1723Decrease in Apolipoprotein C-III (ApoC-III) yields a cardioprotective lipoprotein profile. Here, Valleix et al.reveal a novel ApoC-III variant conferring low plasma ApoC-III concentration and cardioprotection despite renal insufficiency, and, unexpectedly, causing dominant hereditary systemic amyloidosis due to its fibrillogenic nature.Sophie ValleixGuglielmo VeronaNoémie Jourde-ChicheBrigitte NédelecP. Patrizia MangioneFrank BridouxAlain MangéAhmet DoganJean-Michel GoujonMarie LhommeCarolane DauteuilleMichèle ChabertRiccardo PorcariChristopher A. WaudbyAnnalisa ReliniPhilippa J. TalmudOleg KovrovGunilla OlivecronaMonica StoppiniJohn ChristodoulouPhilip N. HawkinsGilles GrateauMarc DelpechAnatol KontushJulian D. GillmoreAthina D. KalopissisVittorio BellottiNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-14 (2016) |
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DOAJ |
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EN |
| topic |
Science Q |
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Science Q Sophie Valleix Guglielmo Verona Noémie Jourde-Chiche Brigitte Nédelec P. Patrizia Mangione Frank Bridoux Alain Mangé Ahmet Dogan Jean-Michel Goujon Marie Lhomme Carolane Dauteuille Michèle Chabert Riccardo Porcari Christopher A. Waudby Annalisa Relini Philippa J. Talmud Oleg Kovrov Gunilla Olivecrona Monica Stoppini John Christodoulou Philip N. Hawkins Gilles Grateau Marc Delpech Anatol Kontush Julian D. Gillmore Athina D. Kalopissis Vittorio Bellotti D25V apolipoprotein C-III variant causes dominant hereditary systemic amyloidosis and confers cardiovascular protective lipoprotein profile |
| description |
Decrease in Apolipoprotein C-III (ApoC-III) yields a cardioprotective lipoprotein profile. Here, Valleix et al.reveal a novel ApoC-III variant conferring low plasma ApoC-III concentration and cardioprotection despite renal insufficiency, and, unexpectedly, causing dominant hereditary systemic amyloidosis due to its fibrillogenic nature. |
| format |
article |
| author |
Sophie Valleix Guglielmo Verona Noémie Jourde-Chiche Brigitte Nédelec P. Patrizia Mangione Frank Bridoux Alain Mangé Ahmet Dogan Jean-Michel Goujon Marie Lhomme Carolane Dauteuille Michèle Chabert Riccardo Porcari Christopher A. Waudby Annalisa Relini Philippa J. Talmud Oleg Kovrov Gunilla Olivecrona Monica Stoppini John Christodoulou Philip N. Hawkins Gilles Grateau Marc Delpech Anatol Kontush Julian D. Gillmore Athina D. Kalopissis Vittorio Bellotti |
| author_facet |
Sophie Valleix Guglielmo Verona Noémie Jourde-Chiche Brigitte Nédelec P. Patrizia Mangione Frank Bridoux Alain Mangé Ahmet Dogan Jean-Michel Goujon Marie Lhomme Carolane Dauteuille Michèle Chabert Riccardo Porcari Christopher A. Waudby Annalisa Relini Philippa J. Talmud Oleg Kovrov Gunilla Olivecrona Monica Stoppini John Christodoulou Philip N. Hawkins Gilles Grateau Marc Delpech Anatol Kontush Julian D. Gillmore Athina D. Kalopissis Vittorio Bellotti |
| author_sort |
Sophie Valleix |
| title |
D25V apolipoprotein C-III variant causes dominant hereditary systemic amyloidosis and confers cardiovascular protective lipoprotein profile |
| title_short |
D25V apolipoprotein C-III variant causes dominant hereditary systemic amyloidosis and confers cardiovascular protective lipoprotein profile |
| title_full |
D25V apolipoprotein C-III variant causes dominant hereditary systemic amyloidosis and confers cardiovascular protective lipoprotein profile |
| title_fullStr |
D25V apolipoprotein C-III variant causes dominant hereditary systemic amyloidosis and confers cardiovascular protective lipoprotein profile |
| title_full_unstemmed |
D25V apolipoprotein C-III variant causes dominant hereditary systemic amyloidosis and confers cardiovascular protective lipoprotein profile |
| title_sort |
d25v apolipoprotein c-iii variant causes dominant hereditary systemic amyloidosis and confers cardiovascular protective lipoprotein profile |
| publisher |
Nature Portfolio |
| publishDate |
2016 |
| url |
https://doaj.org/article/20852c4360d64aac8c27c28e258ec648 |
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